Objective: This study aims to investigate the sub-health status of vocational college students in Changchun City. Methods: In this study, 1 282 students from 7 vocational colleges were investigated from June 2018 to December 2018 in Changchun. The questionnaire survey collected information on demographic and lifestyle, as well as sub-health status. Demographic and lifestyle characteristics were analyzed by univariate analysis and were explored associations with sub-health status through binary logistic stepwise regression analysis. Results: A total of 195 cases (15.21%) of physical and psychological sub-health were detected. And fifty-seven male students (13.65%) reported physical and psychological sub-health, which was significantly lower than that of female(16.18%)(χ2=8.00, P=0.01). Those who spent more time online, being irregular eating pattern, smokers and drinkers were more likely to report sub-health(P<0.05). Those who exercised frequently and paid more attention to health were less likely to report sub-health(P<0.05). Multivariate analyses showed that the risk of physical and psychological sub-health status increased among irregular diet, smokers and drinkers(OR=1.41, 1.68, 2.03, P<0.05). Frequent exercise and high attention paid to health was associated with lower risk of physical and psychological sub-health(OR=0.24, 0.55, P<0.05). Conclusion Sub-health status among vocational college students in Changchun is related to irregular diet, smoking, drinking, infrequent exercise and low attention to health. These results suggest health awareness, health education, as well as healthy lifestyle should be strengthened to improve sub-health status of vocational college students.