There is a strong support for a role played by adiponectin in the function of ovary and placenta.There is evidence of direct effects of adiponectin on the late stages of folliculogenesis,and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles.Adiponectin has demonstrated a potential effect on ovarian function as well as a possible effect on the formation of placenta,via multiple mechanisms,providing new strategies for the etiology investigation,prevention and treatment of reproductive and related metabolic diseases.

Polycystic ovary syndrome (PCOS)is the most common cause of anovulatory infertility in women of reproductive age, exerting significant impacts on glucose and lipid metabolism, cardiovascular and endometrial deseases, as well as breast, skin, bone, and psychology fields. As a complex, multi-system of endocrine and metabolic disease, PCOS would be recognized as a component of metabolic syndrome in an overall consideration. The clinical treatment of PCOS is expected to turn simply regulating menstruation and ovulation adjustment into the combination of insulin resistance improvement with antihyperandrogen and ovulation treatment comprehensively.

ObjectiveTo study the rehabilitation for perimenopausal women with stress urinary incontinence.Methods60 perim enopausal women with stress urinary incontinence were randomly divided into groups A, B and C, 20 cases in each group. Group A for pelvic floor exercises, or Kegel training; group B received estrogen in addition; group C received low-frequency electrical stimulation and biofeedback in addition.ResultsUrinary incontinence volume and Kupperman score was positively correlated(r=0.752, P<0.01). Kupperman scores in groups A, B and C were significantly lower(P<0.01) 1 month, 3 months after treatment than before treatment. There was no statistical difference between group A and Group B at 1 month after treatment. Kupperman scores in Group C was significantly lower(P<0.01), and reduced further 3 months after treatment(P<0.01). The amount of urinary incontinence in groups A, B and C were significantly lower 1 month, 3 months after treatment than before treatment(P<0.01). There was no significant difference in urinary volume between group A and group B 1 month and 3 months (P>0.05). The urinary incontinence was significantly lower between group C and groups A, B 1 month, 3 months after treatment (P<0.01).ConclusionThe pelvic floor exercise, low-frequency electrical stimulation and biofeedback therapy can significantly reduce perimenopausal symptoms of stress urinary incontinence.

Clostridiodes difficile(C.difficile)is the most common causative agent of antibiotic-associated diarrhea(ADD)in the world. In recent years,with the emergence of highly resistant and virulent strains,the outbreaks of C.difficile infection have occurred around the world. The incidence,recurrence and mortality of C.difficile infection are on the rise worldwide,and bring great challenges to clinical treatment. Pathogenic strains mainly produce two homologous glycosylation toxins A and B,which can cause symptoms ranging from diarrhea to highly lethal toxic megacolon. In view of the malignant consequences caused by C.difficile infection,disease prevention is still an important way worth exploring. Until now there is no approved vaccine against C.difficile. Therefore,this review assessed the status and challenge of clinical trials of vaccine research for C.difficile.

Objective To solve the problem of continuous augmentation of blood drawing quantity along with the increases of examination item, as well as the problem that patient identifies the lab test with difficulty because of the doctor's handwriting is always illegible. Methods The author introduced data -base management for information technology to increase structured data information and reasonably prepare the process structure. Results The implementation can avoid the repetition of blood drawing, reduce the blood using quantity and the painfulness of patient, and it also provides the standard printing lab test report, as well as the information of the blood drawing time and report taking time. Conclusion The technical improvement of the out -patient blood information system realizes the blood sample sharing and blood quantity reduction, facilitates the patient and blood drawing operator.

Animals ; Antioxidants ; pharmacology ; Cerebellum ; cytology ; Dietary Supplements ; Drugs, Chinese Herbal ; chemistry ; Fruit ; chemistry ; Male ; Muscle Fatigue ; drug effects ; Neurons ; drug effects ; pathology ; Oxidative Stress ; drug effects ; Physical Exertion ; Rats ; Rats, Wistar ; Vegetables ; chemistry

Objective To investigate the value of DNA image cytometry in thediagnose of benign and malignant pleuroperitoneal fluids by comparing with the liquid-based cytological results. Methods There were 417 cases in-volved in this study. Pap stain for cytology analysis and feulgen stain for DNA image cytometry were used to identify benign and malignant pleuroperitoneal fluids respectively,then compared the results of the two methods. Results Clinically or pathologically,213 were classified as malignant and the other 204 as benign. The sensitivity, specifici-ty,accuracy, positive predictive value and negative predictivevalue of DNA image cytometry were 89. 7%,100%, 94. 7%,100%,and 90. 3%,respectively. However,the sensitivity,specificity,accuracy, positive predictive value and negative predictive value of liquid-based cytology were 63. 4%, 81. 9%, 72. 4%, 78. 5%, and 68. 2%, re-spectively. There were significant differences in thesensitivity, specificity,accuracy, positive predictive value and negative predictivevalue. Conclusion DNA image cytometry has great application value in the diagnosis of benign and malignant pleuroperitoneal fluids, and can increase the positive rate, reduce misdiagnosed rate with liquid-based cytology.

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Objective To discuss the mechanism,procedures and effect of implantable intrathecal infusion system for intractable pain therapy. Methods Among the 4 patients with intractable pain,2 had cancer pain,2 had failed back syndrome.Before operation,Visual Analogy Scale(VAS) were 8～10.Three had bolus intrathecal injection screening trial,1 had bolus epidural injection screening trial.In the clinical trail,VAS all decreased to 75%～90%.(Results) They all had intrathecal infusion system implantation.After operation,Morphine was prescribed(intrathecally.) The dose was 1～(8 mg).They all had satisfied pain relief without serious drug adverse effects.Conclusion The effect of implantable intrathecal system for intractable pain was satisfied.The drug adverse effects were obviously alleviated.