1.Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos.
Ihsan ALI ; Syed Zahid Ali SHAH ; Yi JIN ; Zhong Shu LI ; Obaid ULLAH ; Nan Zhu FANG
Journal of Veterinary Science 2017;18(1):1-9
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic development with the increase in protein requirements for cell survival and growth. The ER is a multifunctional cellular organelle responsible for protein folding, modification, and cellular homeostasis. ER stress is activated by a variety of factors including ROS. Such stress leads to activation of the adaptive unfolded protein response (UPR), which restores homeostasis. However, chronic stress can exceed the toleration level of the ER, resulting in cellular apoptosis. In this review, we briefly describe the generation and impact of ROS in preimplantation embryo development, the ROS-mediated activation mechanism of the UPR via the ER, and the subsequent activation of signaling pathways following ER stress in preimplantation embryos.
Apoptosis
;
Blastocyst*
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Cell Survival
;
Embryonic Development
;
Endoplasmic Reticulum
;
Female
;
Homeostasis
;
In Vitro Techniques
;
Organelles
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Oxygen*
;
Pregnancy
;
Protein Folding
;
Reactive Oxygen Species
;
Unfolded Protein Response*
2. Syzygium aromaticum ethanol extract reduces AlCl
Sanila AMBER ; Touqeer AHMED ; Saadia ZAHID ; Syed ALI SHAH ; Syed ALI SHAH
Asian Pacific Journal of Tropical Medicine 2018;11(2):123-130
Objective: To investigate the neuroprotective effects of Syzygium aromaticum (S. aromaticum) extract (500 mg/kg) on AlCl