BACKGROUND: Solar furnaces are used worldwide to conduct experiments to demonstrate the feasibility of solar–chemical processes with the aid of concentrated sunlight, or to qualify high temperature-resistant components. In recent years, high-flux solar simulators (HFSSs) based on short-arc xenon lamps are more frequently used. The emitted spectrum is very similar to natural sunlight but with dangerous portions of ultraviolet light as well. Due to special benefits of solar simulators the increase of construction activity for HFSS can be observed worldwide. Hence, it is quite important to protect employees against serious injuries caused by ultraviolet radiation (UVR) in a range of 100 nm to 400 nm. METHODS: The UV measurements were made at the German Aerospace Center (DLR), Cologne and Paul-Scherrer-Institute (PSI), Switzerland, during normal operations of the HFSS, with a high-precision UV-A/B radiometer using different experiment setups at different power levels. Thus, the measurement results represent UV emissions which are typical when operating a HFSS. Therefore, the biological effects on people exposed to UVR was investigated systematically to identify the existing hazard potential. RESULTS: It should be noted that the permissible workplace exposure limits for UV emissions significantly exceeded after a few seconds. One critical value was strongly exceeded by a factor of 770. CONCLUSION: The prevention of emissions must first and foremost be carried out by structural measures. Furthermore, unambiguous protocols have to be defined and compliance must be monitored. For short-term activities in the hazard area, measures for the protection of eyes and skin must be taken.
Compliance ; Skin ; Sunlight ; Switzerland ; Ultraviolet Rays ; Xenon*

Erysiphe azaleae, a powdery mildew fungus on Rhododendron spp., was originally described from North America, and has only recently been recorded in Germany, England, Switzerland and Poland. The present paper records plentiful collections of this species from Poland, and provides additional information of its anamorphic state for taxonomic purposes.
England ; Fungi ; Germany ; North America ; Poland* ; Rhododendron ; Switzerland

In the treatment of breast cancer, especially in estrogen receptor (ER) positive patients, endocrine therapy has played an important role since bilateral oophorectomy, the first endocrine therapy, was performed by George Thomas Beaston in 1896. Thereafter, various therapeutic modalities such as radiation therapy to ovaries, surgical or medical adrenalectomy, or hypophysectomy, have been used for endocrine therapy in breast cancer. The discovery of ER and the development of anti-estrogens represent substantial progress, and tamoxifen, the first selective ER modulator, has become the gold standard in the endocrine therapy of breast cancer. The therapeutic effects of tamoxifen were confirmed by the 1995 Oxford overview. Recently, the 7th International Conference on Adjuvant Therapy of Primary Breast Cancer held in St. Gallen, Switzerland, recognized the increasing role played by endocrine therapy in properly selected patients groups, especially in younger patients with ER-positive tumors. In addition, recent advances in estrogen research and ER function at the molecular level have provided new strategies as well as a better understanding of endocrine therapy for breast cancer. Lately, new hormonal agents, such as the third-generation aromatase inhibitors, and ER downregulators, showed equivalent or better results in terms of therapeutic effects than tamoxifen. As a result, many clinical trials are ongoing to determine the most appropriate endocrine therapy for breast cancer. Therefore, it is important to maximize the benefits of endocrine therapy in clinical practice in terms of the patient's quality of life as well as the prolongation of patient survival. More studies are needed to determine optimal agents and the duration of therapy, combinations of agents or sequences of therapy according to prognostic and predictive factors.
Adrenalectomy ; Aromatase Inhibitors ; Breast Neoplasms* ; Breast* ; Estrogens ; Female ; Humans ; Hypophysectomy ; Ovariectomy ; Ovary ; Quality of Life ; Switzerland ; Tamoxifen

OBJECTIVES: The purpose of this research was to identify the top 10 most-cited articles on the management of fractured or broken instruments and to perform a bibliometric analysis thereof. MATERIALS AND METHODS: Published articles related to fractured instruments were screened from online databases, such as Web of Science, Scopus, PubMed, and ScienceDirect, and highly cited papers, with at least 50 citations since publication, were identified. The most-cited articles were selected and analysed with regard to publication title, authorship, the journal of publication, year, institution, country of origin, article type, and number of citations. RESULTS: The top 10 most-cited articles were from various journals. Most were published in the Journal of Endodontics, followed by the International Endodontic Journal, and Dental Traumatology. The leading countries were Australia, Israel, Switzerland, the USA, and Germany, and the leading institution was the University of Melbourne. The majority of articles among the top 10 articles were clinical research studies (n = 8), followed by a basic research article and a non-systematic review article. CONCLUSIONS: This bibliometric analysis revealed interesting information about scientific progress in endodontics regarding fractured instruments. Overall, clinical research studies and basic research articles published in high-impact endodontic journals had the highest citation rates.
Australia ; Authorship ; Bibliometrics ; Endodontics ; Germany ; Israel ; Publications ; Root Canal Preparation ; Switzerland ; Traumatology

The anterior approach to arthrodesis of the cervical spine has become a widely accepted. However, anterior interbody fusion in the presence of the posterior instability may be complicated by the bone graft dislodgement, kyphotic deformity or nonunion. As an attempt to prevent this complications, anterior cervical plate after graft placement was introduced. Although, anterior cervical plates provide excellent fixation for the anterior column, potential risk for injury to the spinal cord, soft tissues or screw loosening leading to dysphagia has been reported. Morscher, of Switzerland, has developed an anterior cervical spine locking plate(CLSP) system that attempts to prevent the migration and looseing of screw by using a cross-split screw head that can be locked into the plate. The secondary advantage of this system is the limination of the required posterior cortex purchase. The authors reviewed 42 patients in whom the CLSP system was applied for the treatment of degenerative disease or trauma. With a mean followup of 18 months, all 42 patients went on to fusion. One patient had screws placed in the discal space, hardware failure occurred in two patients. There was no iatrogenic injury to the spinal cord or esophagus. In conclusion, the CLSP system provides a reliable fusion with minimal complications. It should be considered in multilevel anterior cervical arthrosis and cervical fractures.
Arthrodesis ; Congenital Abnormalities ; Deglutition Disorders ; Esophagus ; Follow-Up Studies ; Head ; Humans ; Spinal Cord ; Spine ; Switzerland ; Transplants

The objective of this paper is to chronologically investigate his life as follows: (i) how Henry Sigerist(1891-1957) became interested in medical history, (ii) how he succeeded Karl Sudhoff(1853-1938) as professor of the history of medicine in the University of Leipzig, (iii) why he came to the Johns Hopkins in 1932, (iv) what he did for health care reform in the U. S. and Canada, (v) why he returned to his motherland in 1947, and (vi) how health professions have been globally influenced by his life. Based on the solid academic scholarship of medical history and sociology, Sigerist was energetically engaged in health care reform. What distinguished his social activism from other health care reforms is that whereas most health care reformers take the positivism-centered perspective to transform the existing health care system, Sigerist integrated historical vision with sociologically pedagogic mission to pursue health care progress.
English Abstract ; Germany ; *Historiography ; *History of Medicine ; History of Medicine, 20th Cent. ; Politics ; Professional Practice/*history ; Sociology/*history ; Switzerland ; United States

OBJECTIVE: The purpose of this study was to evaluate the physicochemical properties and cytocompatibility of microporous, spherical biphasic calcium phosphate(BCP) ceramics with a 60/40 hydroxyapatite/beta-tricalcium phosphate weight ratio for application as a bone graft substitute. MATERIALS AND METHODS: Microporous, spherical BCP granules(MGSB) were prepared and their basic characteristics were compared with commercially available BCP(MBCP; Biomatlante, France) and deproteinized bovine bone mineral(Bio-Oss; Geistlich-Pharma, Switzerland, BBP; Oscotec, Korea). Their physicochemical properties were evaluated by scanning electron microscopy, X-ray diffractometry, Fourier-transform infrared spectroscopy, inductively coupled plasma atomic emission spectrometer, and Brunauer-Emmett-Teller method. Cell viability and proliferation of MC3T3-E1 cells on different graft materials were evaluated. RESULTS: MGSB granules showed a chemical composition and crystallinity similar with those in MBCP, they showed surface structure characteristic of three dimensionally, well-interconnected micropores. The results of MTT assay showed increases in cell viablity with increasing incubation times. At 4d of incubation, MGSB, MBCP and BBP showed similar values in optical density, but Bio-Oss exhibited significantly lower optical density compared to other bone substitutes(p < 0.05). MGSB showed significantly greater cell number compared to other bone substitutes at 3, 5, and 7d of incubation(p < 0.05), which were similar with those in polystyrene culture plates. CONCLUSION: These results indicated the suitable physicochemical properties of MGSB granules for application as an effective bone graft substitute, which provided compatible environment for osteoblast cell growth. However, further detailed studies are needed to confirm its biological effects on bone formation in vivo.
Bone Substitutes ; Calcium* ; Cell Count ; Cell Survival ; Ceramics* ; Crystallins ; Microscopy, Electron, Scanning ; Osteoblasts ; Osteogenesis ; Plasma ; Polystyrenes ; Spectrum Analysis ; Switzerland ; Transplants*

AIMTo analyse the possible effect of seasonal variation on semen parameters.

METHODSThe participants consisted of 1,688 men attending the andrology laboratory between 1991 and 1997 for reduced fertility in the couple. Semen analysis was performed according to the WHO manual. The 84 individual months of the study period were each assigned to one of the three groups according to the average monthly outside temperature; Group A (temperature < 4.4 degrees C), Group B (4.4 degrees C - 13.3 degrees C) and Group C (>13.3 degrees C).

RESULTSWhen comparing the different sperm parameters, the morphology was significantly better in Group C. However, when the smokers were analysed separately, this difference disappeared and significant seasonal variations were found in sperm density, total sperm count, motility and total motile sperm; they were deteriorated in the warmer season. In non-smokers, no such negative effect of increased temperature was observed.

CONCLUSIONSperm quality is influenced by seasonal factors. Increased environmental temperature, (maybe also light exposure) has an additional negative effect on the spermatogenesis in smokers, leading to reduced sperm quality in men with borderline fertility.

Adult ; Fertility ; drug effects ; physiology ; Humans ; Male ; Reference Values ; Seasons ; Semen ; physiology ; Smoking ; physiopathology ; Sperm Count ; Sperm Motility ; Switzerland ; Temperature

BACKGROUND: The aim of this study is to examine the prevalence of musculoskeletal complaints in Swiss operating room (OR) nurses, and to investigate how work-family conflict, work interruptions, and influence at work are related to lumbar and cervical back pain. METHODS: Participants in this correlational questionnaire study included 116 OR nurses from eight different hospitals in Switzerland. RESULTS: We found that 66% of the OR staff suffered from musculoskeletal problems. The most prevalent musculoskeletal complaints were lumbar (52.7%) and cervical pain (38.4%). Furthermore, 20.5% reported pain in the mid spine region, 20.5% in the knees and legs, and 9.8% in the hands and feet. Multiple linear regression analyses showed that work-family conflict (p < 0.05) and interruptions (p < 0.05) significantly predicted lumbar and cervical pain in OR nurses, while influence at work (p < 0.05) only predicted lumbar pain. CONCLUSION: These results suggest that reducing the work-family conflict and interruptions at work, as well as offering opportunities to influence one's workplace, help to promote OR nurses' health.
Back Pain ; Foot ; Hand ; Knee ; Leg ; Linear Models ; Musculoskeletal Pain* ; Neck Pain ; Operating Rooms* ; Prevalence ; Spine ; Switzerland

OBJECTIVES: The aim of this study was to describe general practitioners (GPs)' opinions and practices of preventive care and patients' opinions, attitudes, and behaviors towards prevention. METHODS: The data stemmed from a cross-sectional national survey on prevention conducted in Switzerland from 2015 to 2016. In total, 170 randomly drawn GPs and 1154 of their patients participated. The GPs answered an online questionnaire and the patients answered a questionnaire administrated by fieldworkers present at their practices. RESULTS: Both patients and GPs agreed that delivering preventive care is the dedicated role of a GP. It appeared that beyond classical topics of prevention such as cardiovascular risk factors, other prevention areas (e.g., cannabis consumption, immunization, occupational risks) were scarcely covered by GPs and reported as little-known by patients. In addition, GPs seemed to use a selective approach to prevention, responding to the clinical context, rather than a systematic approach to health promotion. The results also highlight possibilities to improve prevention in family medicine through options such as more supportive tools and public advertising, more time and more delegated tasks and, finally, a more recognized role. CONCLUSIONS: Despite an unfavorable context of prevention within the healthcare system, preventive care in family medicine is reasonably good in Switzerland. However, some limitations appear regarding the topics and the circumstances of preventive care delivery. A global effort is needed to implement necessary changes, and the responsibility should be broadened to other stakeholders.
Cannabis ; Cross-Sectional Studies ; Delivery of Health Care ; General Practitioners ; Health Personnel ; Health Promotion ; Humans ; Immunization ; Risk Factors ; Switzerland