1.Neutrophilic Dermatoses as a Continuous Spectrum: An Illustrative Case.
Pei Ming YEO ; Ki Wei TAN ; Regina Sp LIM ; Sim Chee SENG ; Jeannie Pl ONG ; Ratna RAJARATNAM
Annals of the Academy of Medicine, Singapore 2016;45(12):569-571
Facial Dermatoses
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diagnosis
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pathology
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Humans
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Male
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Pyoderma Gangrenosum
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diagnosis
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pathology
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Sweet Syndrome
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diagnosis
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pathology
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Young Adult
2.A Case of Sweet's Syndrome in a Patient with Liver Cirrhosis Caused by Chronic Hepatitis B.
Chang Wook PARK ; Yoon Jung KIM ; Hye Jin SEO ; Kyung In LEE ; Byung Kuk JANG ; Jae Seok HWANG ; Woo Jin CHUNG
The Korean Journal of Gastroenterology 2012;59(6):441-444
Sweet's syndrome (SS), also known as acute febrile neutrophilic dermatosis, is characterized by the sudden onset of painful erythematous skin lesions together with fever and neutrophilia. SS can be associated with several disorders, such as malignancy, autoimmune disease, and infections. However, SS associated with liver cirrhosis is uncommon. We report a case of SS in a patient who was diagnosed with liver cirrhosis caused by chronic hepatitis B.
Hepatitis B, Chronic/complications/*diagnosis
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Humans
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Liver Cirrhosis/*diagnosis/etiology
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Male
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Middle Aged
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Neutrophils/immunology/pathology
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Skin Diseases/*diagnosis/pathology
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Sweet Syndrome/*diagnosis/pathology
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Tomography Scanners, X-Ray Computed
3.Sweet's syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid.
Chi Jun PARK ; Young Deok BAE ; Ji Yong CHOI ; Pil Seog HEO ; Keun Seok LEE ; Young Suk PARK ; Jung Ae LEE
The Korean Journal of Internal Medicine 2001;16(3):218-221
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Quite many ATRA-related side effects, including retinoic acid syndrome, were reported. So far, it has rarely been reported that Sweet's syndrome, characterized by fever, neutrophilia, painful erythematous cutaneous plaques, dense dermal infiltrates of mature neutrophils and rapid response to steroid therapy, is associated with ATRA. In the case that Sweet's syndrome associated with ATRA is found, physicians will have to face a great challenge over the possibility of infectious conditions. We present here a case of Sweet's syndrome associated with ATRA. A 35-year-old female with APL developed fever, painful erythematous cutaneous plaques on both cheeks, right wrist and both shins during induction chemotherapy with ATRA. A skin biopsy revealed a dense dermal infiltrate, consisting of mature neutrophils without vasculitis or cutaneous immunoglobulin deposits, which is compatible with Sweet's syndrome. Oral prednisone was administered and the lesions started to improve within 48 hours
Adult
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Biopsy, Needle
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Case Report
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Female
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Follow-Up Studies
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Human
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Leukemia, Promyelocytic, Acute/diagnosis/*drug therapy
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Prednisone/administration & dosage
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Risk Assessment
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Sweet's Syndrome/*chemically induced/drug therapy/*pathology
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Tretinoin/*adverse effects/therapeutic use
4.Disseminated Mycobacterium kansasii Infection Associated with Skin Lesions: A Case Report and Comprehensive Review of the Literature.
Sang Hoon HAN ; Kyoung Min KIM ; Bum Sik CHIN ; Suk Hoon CHOI ; Han Sung LEE ; Myung Soo KIM ; Su Jin JEONG ; Hee Kyoung CHOI ; Chang Oh KIM ; Jun Yong CHOI ; Young Goo SONG ; June Myung KIM
Journal of Korean Medical Science 2010;25(2):304-308
Mycobacteruim kansasii occasionally causes disseminated infection with poor outcome in immunocompromised patients. We report the first case of disseminated M. kansasii infection associated with multiple skin lesions in a 48-yr-old male with myelodysplastic syndrome. The patient continuously had taken glucocorticoid during 21 months and had multiple skin lesions developed before 9 months without complete resolution until admission. Skin and mediastinoscopic paratracheal lymph node (LN) biopsies showed necrotizing granuloma with many acid-fast bacilli. M. kansasii was cultured from skin, sputum, and paratracheal LNs. The patient had been treated successfully with isoniazid, rifampin, ethmabutol, and clarithromycin, but died due to small bowel obstruction. Our case emphasizes that chronic skin lesions can lead to severe, disseminated M. kansasii infection in an immunocompromised patient. All available cases of disseminated M. kansasii infection in non HIV-infected patients reported since 1953 are comprehensively reviewed.
Antitubercular Agents/therapeutic use
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Clarithromycin/therapeutic use
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Glucocorticoids/therapeutic use
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Humans
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Immunocompromised Host
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Isoniazid/therapeutic use
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Male
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Middle Aged
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Mycobacterium Infections, Nontuberculous/*diagnosis/drug therapy/immunology
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*Mycobacterium kansasii/isolation & purification
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Myelodysplastic Syndromes/drug therapy
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Rifampin/therapeutic use
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Skin Diseases, Bacterial/*diagnosis/immunology/pathology
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Sputum/microbiology
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Sweet Syndrome/diagnosis