A 2-year-old male Tosa was admitted for treatment of a non-healing wound on the right forelimb. Skin tests were unremarkable; however, the lesion contained severe proliferative tissue. Surgical treatment was conducted due to the extensive skin defect and granulation tissue present. Following removal of the proliferative tissue, the wound was closed using the adjustable horizontal mattress suture method with multiple punctate relaxing incisions. The proliferative tissue healed completely after the surgical treatment. This technique can be considered an alternative treatment for the proliferative tissue when conditions require a skin graft or flap after surgical treatment.
Animals ; Child, Preschool ; Dogs* ; Forelimb ; Granulation Tissue ; Humans ; Lower Extremity* ; Male ; Skin ; Skin Tests ; Sutures* ; Transplants ; Wounds and Injuries

Background: Tibial tuberosity transposition (TTT) causes caudalization of the patellar ligament insertion in canine medial patellar luxation, which can lead to increases in patellofemoral contact pressure. Objectives: The purpose of this study is to confirm the effect of patellofemoral contact mechanics after craniolateral and caudolateral transposition of tibial tuberosity in normal canine hindlimbs. Methods: Craniolateral and caudolateral transposition of tibial tuberosity was performed in 5 specimens, respectively. The pressure was measured in the specimen before TTT, and then in the same specimen after TTT. In this process, data was obtained in 10 specimens. The measurement results were output as visualization data through the manufacturer's software and numerical data through spreadsheet. Based on these 2 data and the anatomical structure of the patellofemoral joint (PFJ) surface, whole measurement area was analysed by dividing into medial, lateral and central area. Results: In craniolateralization of tibial tuberosity, total, medial, central contact pressure was decreased and lateral contact pressure was not statistically changed lateral contact pressure than normal PFJ. In caudolateralization of tibial tuberosity, total, lateral contact pressure was increased and medial contact pressure was not statistically changed than normal PFJ. Although not statistically significant changed, central contact pressure in caudolateralization of tibial tuberosity was increased in all 5 specimens. Conclusions These results imply that traditional TTT, prone to caudal shift of patellar tendon, can increase retropatellar pressure may lead to various complications and diseases of the stifle joint.

Abstract: Ten cadavers were studied to compare the accessibility of cervical vertebral canal with conventional standard ventral slot and modified slanted ventral slot. One group performed standard ventral slot procedures at the C3-4, C5-6. The other group performed modified slanted ventral slot with inverted cone technique procedures at the C3-4, C5-6 computed tomography was performed before and after surgery. The accessibility of cervical vertebral canal with conventional standard ventral slot and modified slanted ventral slot using computed tomography in C3-4 and C5-6 intervertebral space was compared. Although smaller ostectomy was performed in the modified slanted ventral slot, some lesions were more accessible but limitations were obvious in C3-4 and C5-6 intervertebral disk space. After the disc material has been identified through accurate preoperative diagnostic imaging, less morbidity and complications can be expected if the appropriate surgical method is selected based on the lesion of compression.

Objectives: We evaluated the efficacy of a medial arthroscopic approach to the coxofemoral joint of dogs by analyzing the joint visible area and performing a safety analysis. Methods: Arthroscopic approaches to the coxofemoral joint were made in five cadavers using a traditional (dorsal) and novel (medial) approach. Three observers scored the visible area of images and videos of the acetabulum and femur. A safety analysis was performed via dissection of the medial hind limb. The distance between neurovascular structures and arthroscopic portals was measured. Results: The acetabulum was more visible in the dorsal than in the medial approach, with mean visualization scores of 16 ± 0.00 and 11.83 ± 1.26, respectively. The medioventral side of the femur was significantly more visible in the medial than in the dorsal approach, with mean visualization scores of 3.9 ± 0.99 and 6.93 ± 0.58, respectively. Safety analysis confirmed the medial portal site was safe, provided that the surgeon has comprehensive knowledge of the joint. The minimum distance from the arthroscopic medial portals to the nearest neurovascular structures was 2.5 mm. Conclusions A medial arthroscopic approach to the canine coxofemoral joint has potential clinical application. Dorsal and medial approaches differ significantly and have distinct purposes. The medial approach is useful to access the ventromedial joint, making it an eligible diagnostic method for an arthroscopic evaluation of this area.

Objective: This study aims to evaluate endoscopic foraminotomy through the iliac window, using three-dimensionally (3D) printing guide based on the preoperative plan, in cadaveric dogs. Methods: Trans-iliac foraminotomies were performed on each side of five canine cadavers using and individualized 3D printing guide. The intervertebral foramen (IVF) area was divided into entrance, middle, and exit zones and the trajectory angle was calculated from the computed tomography data. Results: Trans-iliac foraminotomy with an endoscope through the iliac hole using a 3D printed guide provide good visual access to the L7-S1 region. The variations in IVF in three zones were not significantly different after surgery. The angle of deviation of the guide was not significantly different caudally or ventrally after surgery. The mean trajectory angle after surgery was 14.06 ± 4.61°caudally and 13.07 ± 6.79° ventrally. Conclusions and Relevance: Our results suggest that surgical site were directly visualized during foraminotomy by the lateral approach through the spinal endoscope. However, other procedure including corpectomy and discectomy were not performed in this study.

Objective: This study aims to evaluate endoscopic foraminotomy through the iliac window, using three-dimensionally (3D) printing guide based on the preoperative plan, in cadaveric dogs. Methods: Trans-iliac foraminotomies were performed on each side of five canine cadavers using and individualized 3D printing guide. The intervertebral foramen (IVF) area was divided into entrance, middle, and exit zones and the trajectory angle was calculated from the computed tomography data. Results: Trans-iliac foraminotomy with an endoscope through the iliac hole using a 3D printed guide provide good visual access to the L7-S1 region. The variations in IVF in three zones were not significantly different after surgery. The angle of deviation of the guide was not significantly different caudally or ventrally after surgery. The mean trajectory angle after surgery was 14.06 ± 4.61°caudally and 13.07 ± 6.79° ventrally. Conclusions and Relevance: Our results suggest that surgical site were directly visualized during foraminotomy by the lateral approach through the spinal endoscope. However, other procedure including corpectomy and discectomy were not performed in this study.

Objective: This study aims to evaluate endoscopic foraminotomy through the iliac window, using three-dimensionally (3D) printing guide based on the preoperative plan, in cadaveric dogs. Methods: Trans-iliac foraminotomies were performed on each side of five canine cadavers using and individualized 3D printing guide. The intervertebral foramen (IVF) area was divided into entrance, middle, and exit zones and the trajectory angle was calculated from the computed tomography data. Results: Trans-iliac foraminotomy with an endoscope through the iliac hole using a 3D printed guide provide good visual access to the L7-S1 region. The variations in IVF in three zones were not significantly different after surgery. The angle of deviation of the guide was not significantly different caudally or ventrally after surgery. The mean trajectory angle after surgery was 14.06 ± 4.61°caudally and 13.07 ± 6.79° ventrally. Conclusions and Relevance: Our results suggest that surgical site were directly visualized during foraminotomy by the lateral approach through the spinal endoscope. However, other procedure including corpectomy and discectomy were not performed in this study.

Objective: This study aims to evaluate endoscopic foraminotomy through the iliac window, using three-dimensionally (3D) printing guide based on the preoperative plan, in cadaveric dogs. Methods: Trans-iliac foraminotomies were performed on each side of five canine cadavers using and individualized 3D printing guide. The intervertebral foramen (IVF) area was divided into entrance, middle, and exit zones and the trajectory angle was calculated from the computed tomography data. Results: Trans-iliac foraminotomy with an endoscope through the iliac hole using a 3D printed guide provide good visual access to the L7-S1 region. The variations in IVF in three zones were not significantly different after surgery. The angle of deviation of the guide was not significantly different caudally or ventrally after surgery. The mean trajectory angle after surgery was 14.06 ± 4.61°caudally and 13.07 ± 6.79° ventrally. Conclusions and Relevance: Our results suggest that surgical site were directly visualized during foraminotomy by the lateral approach through the spinal endoscope. However, other procedure including corpectomy and discectomy were not performed in this study.

Background: Post-transplantation cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are common pro‑ phylactic strategies for graft-versus-host disease (GVHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Interleukin (IL)-6 is a surrogate marker for cytokine release syndrome (CRS) and acute GVHD.Method The clinical outcomes and complications of haplo-HSCT with PTCy plus ATG versus PTCy monotherapy were compared according to serum IL-6 levels at Chungnam National University Hospital (Daejeon, South Korea) from Jan‑ uary 2019 to February 2023. Results: Forty patients who underwent haplo-HSCT were analyzed. A significant difference in IL-6 levels was observed between the PTCy plus ATG and PTCy alone groups (7.47 ± 10.55 vs. 117.65 ± 127.67; p = 0.003). More patients in the PTCy plus ATG group had a CRS grade of 0 than in the PTCy alone group (p < 0.001). Serum IL-6 levels were associated with grades II–IV acute GVHD (r = 0.547, p < 0.001). The cumulative incidence (CI) of grades II–IV acute GVHD was significantly higher in the PTCy alone group (67.9% vs. 4.8%; p < 0.001). No significant difference in the CI for chronic GVHD was detected between the PTCy plus ATG and PTCy alone groups (72.1% vs. 82.0%; p = 0.730). The CI of 1-year non-relapse mortality was significantly higher in the PTCy alone group than in the PTCy plus ATG group (42.2% vs. 15.9%; p = 0.022). The 1-year overall survival (OS) was significantly better in the PTCy plus ATG group (75.9% vs. 35.3%; p = 0.011). The 1-year GVHD-free, relapse-free survival rate was 29.4% in the PTCy alone group and 54.0% in the PTCy plus ATG group (p = 0.038). Conclusion Serum IL-6 levels were higher in the PTCy alone group than in the PTCy plus ATG group. The addition of ATG before stem cell infusion affected IL-6 levels and reduced the incidences of CRS and grade II–IV acute GVHD in haplo-HSCT patients. This study suggests that PTCy plus ATG as GVHD prophylaxis in haplo-HSCT is beneficial in terms of clinical outcomes and complications of HSCT.

Background: Post-transplantation cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are common pro‑ phylactic strategies for graft-versus-host disease (GVHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Interleukin (IL)-6 is a surrogate marker for cytokine release syndrome (CRS) and acute GVHD.Method The clinical outcomes and complications of haplo-HSCT with PTCy plus ATG versus PTCy monotherapy were compared according to serum IL-6 levels at Chungnam National University Hospital (Daejeon, South Korea) from Jan‑ uary 2019 to February 2023. Results: Forty patients who underwent haplo-HSCT were analyzed. A significant difference in IL-6 levels was observed between the PTCy plus ATG and PTCy alone groups (7.47 ± 10.55 vs. 117.65 ± 127.67; p = 0.003). More patients in the PTCy plus ATG group had a CRS grade of 0 than in the PTCy alone group (p < 0.001). Serum IL-6 levels were associated with grades II–IV acute GVHD (r = 0.547, p < 0.001). The cumulative incidence (CI) of grades II–IV acute GVHD was significantly higher in the PTCy alone group (67.9% vs. 4.8%; p < 0.001). No significant difference in the CI for chronic GVHD was detected between the PTCy plus ATG and PTCy alone groups (72.1% vs. 82.0%; p = 0.730). The CI of 1-year non-relapse mortality was significantly higher in the PTCy alone group than in the PTCy plus ATG group (42.2% vs. 15.9%; p = 0.022). The 1-year overall survival (OS) was significantly better in the PTCy plus ATG group (75.9% vs. 35.3%; p = 0.011). The 1-year GVHD-free, relapse-free survival rate was 29.4% in the PTCy alone group and 54.0% in the PTCy plus ATG group (p = 0.038). Conclusion Serum IL-6 levels were higher in the PTCy alone group than in the PTCy plus ATG group. The addition of ATG before stem cell infusion affected IL-6 levels and reduced the incidences of CRS and grade II–IV acute GVHD in haplo-HSCT patients. This study suggests that PTCy plus ATG as GVHD prophylaxis in haplo-HSCT is beneficial in terms of clinical outcomes and complications of HSCT.