OBJECTIVE:To establish a method for the determination of the dissolution rates of azithromycin tablets and to compare the dissolution rates among azithromycin tablets that from different manufacturers so as to provide references for clinical medication.METHODS:The concentrations and drug cumulative dissolution rates of a total of 5 batch numbers' azithromycin tablets that from 5 pharmaceutical factories were determined based on the related standard procedure indexed in China Pharmacopoeia(2005 edition),then the dissolution parameters were calculated with Weibull formula.RESULTS:The dissolution rates at 45 min were above 75%,which was up to the standard.The analysis of variance showed that there were significant differences among samples in dissolution parameters(P

Objective To investigate the effect of blood vessels at different locations and angles between blood vessel and sonic axis within the target area on HIFU peripheral ablation.Methods Totally 56 phantoms containing rabbit thoracic a orta were divided into group A (different vessel locations) and B (different vessel angles).According to the distance (d)between the blood vessel center and the deepest (top) layer of the peripheral scanning,group A was divided into A1 (d=0),A2 (d=10 mm),A3 (d=20 mm) subgroups.According to the angle (α) between the vessel long axis and the acoustic axis,group B was divided into B1 (α=0-5°),B2(α=60° 65°),B3 (α=90°-95°),B4 (α=115°-120°) subgroups.A4,B5 subgroups were set as the control groups.The vessel diameter and vessel wall thickness were measured.The lesion morphology was observed and the energy efficiency factor (EEF) was calculated.Results There was no significant difference in vessel diameter and vessel wall thickness in both group A and B (all P＞0.05).There was no residual area in the target area of A1,B1 subgroup,while there was residual area in the target area of the other subgroups.EEF of group A in ascending order were A4,A1,A2 subgroup,and statistically significant differences in pairwise comparisons (all P＜0.05) except for A1 and A3 subgroup (P＞0.05).EEF of group B in ascending order were B5,B2,B3 subgroup,respectively,and statistically significant differences in pairwise comparisons (all P＜0.05) except for B2 and B4,B5 and B1 subgroup (both P＞0.05).Conclusion It is 10 mm that the distance between the blood vessel center and the deepest (top) layer of the pe ripheral scanning,and 90°-95° that the angle between the vessel long axis and the acoustic axis has the greatest influence on the ablation of the target area.

Objective:To evaluate the efficacy of Baixiao moxibustion combined with acupuncture in the treatment of patients with dysmenorrhea of cold coagulation and blood stasis.Methods:A total of 90 patients with dysmenorrhea of cold coagulation and blood stasis who were treated in Huangpu Branch of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine and met the inclusion criteria were enrolled between January 2019 and January 2020, and they were divided into observation group (47 patients) and control group (43 patients) according to the random number table method. The control group was treated by acupuncture, while the observation group combined Baixiao moxibustion with acpuncture treatment. Both groups were treated for 3 menstrual cycles. Before and after treatment, TCM syndromes were scored, Visual Analogue Scale (VAS) was used to evaluate pain intensity, and uterine hemodynamics were detected by ultrasonic diagnostic apparatus. The pulsatility index (PI), resistance index (RI) and ratio of peak systole/peak diastole (S/D) were recorded and the clinical efficacy was assessed.Results:The total effective rate was 97.87% (46/47) in observation group and that in control group was 81.40% (35/43), and the difference between two groups were significant ( χ2=6.77, P=0.009). After treatment, the scores of lower abdominal pain, dark blood clots, intolerance of cold and cold limbs and nausea and vomiting as well as VAS scores in the observation group were significantly lower than those in the control group ( t=3.61, 5.60, 6.22, 8.02, 10.36, all Ps<0.01). After treatment, the RI (1.45±0.55 vs. 1.86±0.53, t=3.59), PI (0.61±0.14 vs. 0.77±0.13, t=5.60) and S/D (5.28±1.18 vs. 7.23±1.22, t=7.71) in observation group were significantly lower than those in control group ( P<0.01). Conclusion:Baixiao moxibustion combined with acupuncture can relieve the pain symptoms, improve the TCM syndromes and promote the uterine blood circulation.

Objective To explore the impact of different angles between blood vessels and acoustic axis in the target area on pulse high intensity focused ultrasound (PHIFU) peripheral ablation.Methods Thirty New Zealand rabbits were selected,and the thoracic aortas were obtained.Models of tissue mimicking material were used via embedding the rabbit thoracic aorta into the center of the target barrier area.Then the models were divided into 0°,45° and 90° groups according to the angles with the acoustic axis,and the control group was set up as well (each n =10).Under B-ultrasound monitoring,PHIFU peripheral ablation was performed with the same parameters in each group.The temperature was measured during ablation.After ablation,the models were cut step by step for macroscopic and ultrasound observation.The total volumes (V) were calculated and compared,and the target blood vessels were sampled for pathological examination.Results The peripheral region in control group showed strong echo on ultrasound image,while in 0°,45° and 90° group the blood vessels showed low echo accordingly.The maximal temperatures in control group,0°,45° and 90° group was (98.60 ± 5.76) ℃,(98.90 ± 7.09) ℃,(71.10 ± 13.85) ℃ and (70.20 ± 9.14) ℃,respectively.Statisticaldifference was found between control group and 45°,90° group (all P＜0.05).The total volume in control group,0°,45° and 90° group was (40 709.70 ± 3 193.31) mm3,(40 029.02 ± 3 580.17) mm3,(34 562.59 ± 3 883.26) mm3 and (36 737.01± 3 278.68)mm3,respectively,while no statistical difference was found between control group and 0° group (P＞0.05).Pathological examination showed that the elastic fibers fractured partly,and disruption of cell nucleus were observed in 45° and 90° group.Conclusion When the angle between the blood vessel and acoustic axis is 0°,its impact on energy deposition is minimally,while the destruction of the vascular wall becomes stronger when the angle is 45°and 90°.