Objective The aim of this study was to investigate the effectiveness of treatment, survival and prognostic factors in Chinese patients with Hodgkin lymphoma. Methods A total of previously untreated 415 patients with histologically confirmed Hodgkin lymphoma admitted in the Cancer Hospital, Chinese Academy of Medical Sciences from February 1999 to February 2011 were included in this study. Their short?term and long?term survivals, as well as prognostic factors were analyzed. Results For the whole group, 371 cases (89.4%) had complete remission (CR), 33 cases (8.0%) had partial remission (PR) and 11 cases (2.7%) experienced disease progression. The CR rates for stage Ⅰ, Ⅱ, Ⅲ and Ⅳ patients were 96.6% (56/58), 92.0% (219/238), 83.6% (51/61) and 77.6% (45/58), respectively (P<0.001) . The 5?year disease?free survival( DFS) , progression?free survival ( PFS) and overall survival ( OS) were 90.6%, 84.1% and 92.5%. The stageⅠ?Ⅱpatients were significantly better than stageⅢ?Ⅳpatients in terms of 5?year DFS rate(94.5% vs. 79.2%, P<0.001), 5?year PFS rate (91.2% vs. 66.4%, P<0.001) and 5?year OS rate (97.0% vs. 81.5%, P<0.001). For stage Ⅰ?Ⅱ patients, combined modality therapy was related to better DFS, PFS and OS as compared with radiotherapy alone, and was associated with a better PFS compared with chemotherapy alone. There was a trend that consolidative radiotherapy could improve the long?term survival for stage Ⅲ?Ⅳ patients who achieved disease remission after chemotherapy. What′s more, consolidative radiotherapy could significantly improve PFS for those stage Ⅲ?Ⅳ patients who achieved PR after chemotherapy. Multivariate analysis showed that clinical stage and pathological type were independent prognostic factors for the 5?year DFS rate (both P<0.05), and the stage, elevated serum β2?microglobulin and none?ABVD/BEACOP chemotherapy regimen were independent prognostic factors for 5?year PFS rate and 5?year overall survival rate (P<0.05 for all). Conclusions Patients with HL treated in China have a good prognosis. Combined modality therapy is the preferred treatment for stage Ⅰ?Ⅱ patients. Consolidative radiotherapy is recommended to those of stage Ⅲ?Ⅳ patients who experienced PR after chemotherapy. Stage, serum β2?microglobulin and first?line chemotherapy regimen significantly affect the prognosis for patients with Hodgkin lymphoma.

Objective To investigate age-and sex-related changes in choroid plexus(CP)volume in healthy adults,as well as its association with the volumes of other brain regions,and explore the relationship of CP volume changes with degenerative brain alterations.Methods A total of 320 healthy subjects aged between 18 and 85 years were prospectively recruited in Physical Examination Center of First Affiliated Hospital to Army Medical University during August 2023 and February 2024.These participants were randomly divided into 7.OT and 3.OT groups,with 160 people in each group.After all of them underwent sagittal three-dimensional structural MPRAGE scans of magnetic resonance imaging(MRI)at 3.OT or7.OT,FreeSurfer 6.0 segmentation software was employed to obtain the volumes of CP and other brain regions automatically.Spearman analysis was applied to analyze the correlation of CP volume with age.Independent sample t-test analysis was applied to analyze the differences in CP volume between genders.Partial correlation analysis was performed to analyze the correlation between CP volume and the volumes of other brain regions.Results A total of 311 subjects were included in the study.The results from both 3.OT and 7.OT MRI showed that CP volume was positively correlated with age(3.OT:r=0.462,P＜0.001;7.OT:r=0.539,P＜0.001).The males had significantly larger CP volume than the females(3.OT:1.4±0.47 vs 1.08±0.39 mL,P＜0.001;7.OT:2.43±0.68 vs 1.98±0.38 mL,P＜0.001).In addition,3.OT MRI revealed there was a significant positive correlation of CP volume with the volumes of white matter hyperintensities(WMH)and cerebrospinal fluid(P＜0.001),as well as a negative correlation with the volumes of gray matter,white matter,hippocampus and thalamus(P＜0.05).Conclusion CP volume is increased with ageing,with gender differences,independent of field strength and resolution.CP volume is correlated with WMH,hippocampus and other brain regions,suggesting that increment in CP volume is involved in age-related degenerative changes in the brain.Changes in CP volume might be regarded as a new imaging marker for the neurodegenerative changes.

Objective The aim of this study was to investigate the effectiveness of treatment, survival and prognostic factors in Chinese patients with Hodgkin lymphoma. Methods A total of previously untreated 415 patients with histologically confirmed Hodgkin lymphoma admitted in the Cancer Hospital, Chinese Academy of Medical Sciences from February 1999 to February 2011 were included in this study. Their short?term and long?term survivals, as well as prognostic factors were analyzed. Results For the whole group, 371 cases (89.4%) had complete remission (CR), 33 cases (8.0%) had partial remission (PR) and 11 cases (2.7%) experienced disease progression. The CR rates for stage Ⅰ, Ⅱ, Ⅲ and Ⅳ patients were 96.6% (56/58), 92.0% (219/238), 83.6% (51/61) and 77.6% (45/58), respectively (P<0.001) . The 5?year disease?free survival( DFS) , progression?free survival ( PFS) and overall survival ( OS) were 90.6%, 84.1% and 92.5%. The stageⅠ?Ⅱpatients were significantly better than stageⅢ?Ⅳpatients in terms of 5?year DFS rate(94.5% vs. 79.2%, P<0.001), 5?year PFS rate (91.2% vs. 66.4%, P<0.001) and 5?year OS rate (97.0% vs. 81.5%, P<0.001). For stage Ⅰ?Ⅱ patients, combined modality therapy was related to better DFS, PFS and OS as compared with radiotherapy alone, and was associated with a better PFS compared with chemotherapy alone. There was a trend that consolidative radiotherapy could improve the long?term survival for stage Ⅲ?Ⅳ patients who achieved disease remission after chemotherapy. What′s more, consolidative radiotherapy could significantly improve PFS for those stage Ⅲ?Ⅳ patients who achieved PR after chemotherapy. Multivariate analysis showed that clinical stage and pathological type were independent prognostic factors for the 5?year DFS rate (both P<0.05), and the stage, elevated serum β2?microglobulin and none?ABVD/BEACOP chemotherapy regimen were independent prognostic factors for 5?year PFS rate and 5?year overall survival rate (P<0.05 for all). Conclusions Patients with HL treated in China have a good prognosis. Combined modality therapy is the preferred treatment for stage Ⅰ?Ⅱ patients. Consolidative radiotherapy is recommended to those of stage Ⅲ?Ⅳ patients who experienced PR after chemotherapy. Stage, serum β2?microglobulin and first?line chemotherapy regimen significantly affect the prognosis for patients with Hodgkin lymphoma.

Objective To evaluate the effect and cost-benefit of influenza vaccination for patients with chronic diseases in Wujin district of Changzhou City. Methods An epidemiological quasi-experiment was employed in this study. A total of 441 patients with chronic diseases were recruited as the vaccine group and inoculated with trivalent influenza virus vaccine, while 467 patients with chronic diseases matched with the age, gender and health status of the vaccine group were selected as the control group for both baseline and follow-up investigations. Results A total of 431 subjects in the vaccine group and 460 subjects in the control group completed baseline and 1-year follow-up investigations. The incidence of influenza-like illness was 7.42% (32/431) and 14.13% (65/460) in the vaccine group and the control group, respectively, with a statistically significant difference (χ²=9.634, P=0.002). The protective rate was 47.46%, and the effect index was 1.90. The incidence of common cold was 16.94% (73/431) and 25.43% (117/460), respectively, and the difference was statistically significant (χ²=9.077, P=0.003), with a protective rate of 33.41%, and an effect index of 1.50. The incidence of chronic disease was 5.57% (24/431) and 9.35% (43/460), respectively. The difference was statistically significant (χ²=4.043, P=0.044), with a protective rate of 40.43% and an effect index of 1.68. The per capita benefit of inoculation was 675.86 yuan, and the benefit-cost ratio was 10.09:1. Conclusion Influenza vaccination for patients with chronic diseases effectively prevented the occurrence of influenza-like illness and reduced the incidence of related chronic diseases.

OBJECTIVEThe aim of this study was to investigate the effectiveness of treatment, survival and prognostic factors in Chinese patients with Hodgkin lymphoma.

METHODSA total of previously untreated 415 patients with histologically confirmed Hodgkin lymphoma admitted in the Cancer Hospital, Chinese Academy of Medical Sciences from February 1999 to February 2011 were included in this study. Their short-term and long-term survivals, as well as prognostic factors were analyzed.

RESULTSFor the whole group, 371 cases (89.4%) had complete remission (CR), 33 cases (8.0%) had partial remission (PR) and 11 cases (2.7%) experienced disease progression. The CR rates for stage I, II, III and IV patients were 96.6% (56/58), 92.0% (219/238), 83.6% (51/61) and 77.6% (45/58), respectively (P < 0.001). The 5-year disease-free survival (DFS), progression-free survival (PFS) and overall survival (OS) were 90.6%, 84.1% and 92.5%. The stage I-II patients were significantly better than stage III-IV patients in terms of 5-year DFS rate (94.5% vs. 79.2%, P < 0.001), 5-year PFS rate (91.2% vs. 66.4%, P < 0.001) and 5-year OS rate (97.0% vs. 81.5%, P < 0.001). For stage I-II patients, combined modality therapy was related to better DFS, PFS and OS as compared with radiotherapy alone, and was associated with a better PFS compared with chemotherapy alone. There was a trend that consolidative radiotherapy could improve the long-term survival for stage III-IV patients who achieved disease remission after chemotherapy. What's more, consolidative radiotherapy could significantly improve PFS for those stage II-IV patients who achieved PR after chemotherapy. Multivariate analysis showed that clinical stage and pathological type were independent prognostic factors for the 5-year DFS rate (both P < 0.05), and the stage, elevated serum β2-microglobulin and none-ABVD/BEACOP chemotherapy regimen were independent prognostic factors for 5-year PFS rate and 5-year overall survival rate (P < 0.05 for all).

CONCLUSIONSPatients with HL treated in China have a good prognosis. Combined modality therapy is the preferred treatment for stage I-II patients. Consolidative radiotherapy is recommended to those of stage III-IV patients who experienced PR after chemotherapy. Stage, serum β2-microglobulin and first-line chemotherapy regimen significantly affect the prognosis for patients with Hodgkin lymphoma.

Antineoplastic Agents ; therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Bleomycin ; China ; Combined Modality Therapy ; mortality ; Dacarbazine ; Disease Progression ; Disease-Free Survival ; Doxorubicin ; Hodgkin Disease ; mortality ; pathology ; therapy ; Humans ; Multivariate Analysis ; Prognosis ; Radiotherapy, Adjuvant ; mortality ; Remission Induction ; Survival Rate ; Treatment Outcome ; Vinblastine ; beta 2-Microglobulin ; blood