OBJECTIVE: To improve the diagnosis and treatment of the external auditory canal cholesteatoma (EACC). METHOD: The data of 18 patients caused by EACC were analysed retrospectively. RESULT: In all cases, the cholesteatomas were found in the external auditory canal and the mastoid cavity. CT scanning was using for definition the ranging of lesions and the timm management surgery was completed. There was no recurrence in 10-40 months follow-up. CONCLUSION EACC is easily misdiagnosed as keratosis obturans (KO). The disease can progress to extensive mastoid destruction. CT of temporal bone and detailed history is necessary in the diagnosis. Early complete surgical treatment is the best method.
Adult ; Aged ; Cholesteatoma ; diagnosis ; therapy ; Ear Canal ; pathology ; Ear Diseases ; diagnosis ; therapy ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult

Objective:To retrospectively analyze the incidence, mortality, clinical characteristics and related factors of transient and persistent acute kidney injury in patients with sepsis in emergency department.Methods:Patients with sepsis ≥ 18 years old hospitalized in the Emergency Department of Guangdong Provincial Hospital of Chinese Medicine from June 2018 to May 2020 were selected as the research objects. According to the renal function injury at admission and the renal function recovery at 48 h after admission, patients with sepsis were divided into three groups: non-S-AKI group, transient S-AKI group, and persistent S-AKI group.Results:A total of 197 patients with sepsis were included, including 95 patients with non-S-AKI, 39 patients with transient S-AKI and 63 patients with persistent S-AKI. The mortality in the persistent S-AKI group was significantly higher than that in the non-S-AKI group (36.5% vs. 17.9%, P<0.05), but there was no significant difference between the transient S-AKI group and non-S-AKI group (20.5% vs. 17.9%, P>0.05). Multiple categorical disordered Logistic regression analysis showed that urea was associated with transient S-AKI ( OR=1.440, 95% CI: 1.235-1.680), and age ( OR=1.049, 95% CI: 1.008-1.092), urea ( OR=1.440, 95% CI: 1.277-1.733), and infection site in non-urinary tract ( OR=0.149, 95% CI: 0.050-0.448) were associated with persistent S-AKI. Conclusions:The incidence of persistent S-AKI is higher than that of transient S-AKI. Persistent S-AKI is related to the prognosis of patients with sepsis, and the mortality rate is higher, while transient S-AKI has no significant relationship. The urea of patients with S-AKI would increase significantly, and advanced age and urinary tract infection are related factors for the occurrence of persistent S-AKI. For patients with sepsis with such factors, attention should be paid to early protection of renal function to prevent persistent S-AKI.

Objective To investigate age-and sex-related changes in choroid plexus(CP)volume in healthy adults,as well as its association with the volumes of other brain regions,and explore the relationship of CP volume changes with degenerative brain alterations.Methods A total of 320 healthy subjects aged between 18 and 85 years were prospectively recruited in Physical Examination Center of First Affiliated Hospital to Army Medical University during August 2023 and February 2024.These participants were randomly divided into 7.OT and 3.OT groups,with 160 people in each group.After all of them underwent sagittal three-dimensional structural MPRAGE scans of magnetic resonance imaging(MRI)at 3.OT or7.OT,FreeSurfer 6.0 segmentation software was employed to obtain the volumes of CP and other brain regions automatically.Spearman analysis was applied to analyze the correlation of CP volume with age.Independent sample t-test analysis was applied to analyze the differences in CP volume between genders.Partial correlation analysis was performed to analyze the correlation between CP volume and the volumes of other brain regions.Results A total of 311 subjects were included in the study.The results from both 3.OT and 7.OT MRI showed that CP volume was positively correlated with age(3.OT:r=0.462,P＜0.001;7.OT:r=0.539,P＜0.001).The males had significantly larger CP volume than the females(3.OT:1.4±0.47 vs 1.08±0.39 mL,P＜0.001;7.OT:2.43±0.68 vs 1.98±0.38 mL,P＜0.001).In addition,3.OT MRI revealed there was a significant positive correlation of CP volume with the volumes of white matter hyperintensities(WMH)and cerebrospinal fluid(P＜0.001),as well as a negative correlation with the volumes of gray matter,white matter,hippocampus and thalamus(P＜0.05).Conclusion CP volume is increased with ageing,with gender differences,independent of field strength and resolution.CP volume is correlated with WMH,hippocampus and other brain regions,suggesting that increment in CP volume is involved in age-related degenerative changes in the brain.Changes in CP volume might be regarded as a new imaging marker for the neurodegenerative changes.