Chronic kidney disease (CKD) has recently been reported to be an independent risk factor for stroke. However, a detailed analysis was yet to be conducted according to stroke subtype. We attempted to determine the risk factors for stroke using data from the “specific health checkup” for metabolic syndrome conducted by the 9 hospitals affiliated with the Akita Prefectural Federation of Agricultural Cooperatives, and evaluate and determine the risk factors for stroke. There were 401 patients who had undergone metabolic syndrome checkups from 2007 and 2010 and suffered from stroke afterwards within 3 years after the screening. The controls were all 69,407 subjects who were screened during the same period. The predictors examined were sex, age, blood pressure, BMI, cholesterol values (HDL・LDL), history of diabetes mellitus, presence of atrial fibrillation, CKD, and drinking and smoking habits. Analysis was conducted using logistic regression. The risk factors for stroke as a whole were male sex, age, blood pressure, diabetes, atrial fibrillation, CKD, and smoking history. For cerebral infarction, the risk factors were male sex, age, blood pressure, diabetes, atrial fibrillation, CKD, and smoking habit. The risk factors for cerebral hemorrhage were age, blood pressure, and CKD. For subarachnoid hemorrhage, the risk factors were female sex, age, blood pressure, low HDLemia, and CKD. In conclusion, CKD is an independent risk factor for the 3 subtypes of stroke, and in particular plays an important role as a higher risk factor for cerebral hemorrhage. Smoking cessation and controls of blood pressure, diabetes and atrial fibrillation are the important measures for stroke prevention. In addition, the further intervention should also be targeted to those with the result of CKD revealed by specific health checkups.

We evaluated the role of pharmacists in an interdisciplinary pain center using text mining analysis. We investigated 28 patients who visited an interdisciplinary pain center from May 2014 to July 2015. All patients were interviewed by a pharmacist. Further, we performed morphological analysis of medical records; classification of appearing words into “medicines/side effects,” “diagnosis/disease name,” “pain site,” “pain characteristics/concomitant symptoms,” “life/environment,” and “mental”; and correspondence analysis. The frequently appearing words “pain characteristics/concomitant symptoms” and “medicines/side effects” were used by 47.2% doctors and 35.3% pharmacists, respectively. In the correspondence analysis, doctors frequently referred to “pain characteristics/concomitant symptoms,” pharmacists frequently referred to “medicines/side effects,” and nurses frequently referred to “life/environment” and “pain site.” The fact that the three occupations used distinguishing phrases suggests that each is specialized in a distinct area. At an interdisciplinary pain center, we interviewed a nurse, a pharmacist, and a doctor, and shared information from various angles. The pharmacist focused on listening to the “medicines/side effects,” which is information related to his profession. Pharmacists contribute to medical care by recording information in medical records and sharing the information with other occupations. It is necessary to continue to provide information related to our specialized profession, respect each other, and provide high-quality medical care.

Distigmine has reversible and persistent cholinesterase (ChE) antagonism, and is used for the dysuria due to low activity bladders such as the neurogenic bladder dysfunction widely postoperatively, but fatal cases were reported by cholinergic syndrome. Therefore a dose was limited to 5mg only for adaptation of “the dysuria due to hypotonic bladder such as after surgery and the neurogenic bladder dysfunction” in March, 2010. In the current study, we examined a ministerial policy in the package insert revision using Japanese Adverse Drug Event Report database (JADER). Using a side effect report registered with JADER from January, 2004 to June, 2016, we calculated Reporting Odds Ratio (ROR) which was the index of the safe signal of the medical supplies adverse event and we compared number of reports and ROR of the cholinergic syndrome by the distigmine in approximately the measure in March, 2010 and evaluated it. The number of reports of the cholinergic syndrome by the distigmine was 138 cases before March 2010 and 65 cases after March 2010. After a measure, the number of reports decreased. The possibility that the package insert revision of the distigmine contributed to a decrease in cholinergic syndrome onset was suggested. Whereas monitoring careful sequentially needs the onset of the cholinergic syndrome in constant frequency to be found.