1.Computed Tomography and Magnetic Resonance Imaging Features of a Huge Cavernous Hemangioma in the Pleural Space: A Case Report
Soonchunhyang Medical Science 2022;28(2):150-154
A 44-year-old male with a huge left pleural mass was admitted due to chest discomfort. Chest computed tomography showed a large pleural mass with punctate calcification and serpentine-shaped enhancement in the left pleural space. Magnetic resonance imaging showed markedly high signal intensity with septa on fat-suppressed T2-weighted imaging (WI) and gradual peripheral delayed enhancement on dynamic-enhancing T1-WI. With hemangioma as the suspected diagnosis, the entire mass was surgically removed carefully and the final histopathological diagnosis was confirmed to be a cavernous hemangioma. Cavernous hemangioma of the pleural space is a rare benign vascular tumor. Precise radiologic diagnosis is important before the surgical operation of hemangiomas because of risk of massive hemorrhage requiring meticulous bleeding control.
2.Minimal Deviation Endometrioid Adenocarcinoma of the Uterine Cervix: A Case Report.
Kye Won KWON ; Susie CHIN ; Hee Kyung KIM ; Eun Seok KOH ; Kyu Rae KIM ; Kye Hyun NAM
Korean Journal of Pathology 2008;42(4):240-243
We describe here a case of minimal deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix that was initially suspected according to the abnormal cytologic findings in a 39-year-old woman. The Papanicolaou (pap) smear showed many neoplastic glandular cells in monolayered sheets, rosettes, and clusters with palisading and feathering borders. The tumor cells had oval, hyperchromatic nuclei, with chromatin clumping and small nucleoli. Histologic examination disclosed endometrial-type glands with a bland, isolated, mainly rounded appearance and these glands were widely scattered deep into the cervical stroma with only scant stromal reaction. An association of MDEA with tubo-endometrioid metaplasia or cervical endometriosis has been suggested by identifying the tubo-endometrioid glands in the vicinity of the MDEA.
Female
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Humans
;
Adenocarcinoma
3.A Case of Papillary Intestinal Type Sinonasal Adenocarcinoma of the Nasal Cavity.
Chan Goo LEE ; Young Joo PARK ; Susie CHIN ; Jae Yong LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 2013;56(5):310-313
Malignant tumors of the sinonasal tract are relatively rare and adenocarcinomas of various types account for 10% to 20% of primary malignancies of the nasal cavity and paranasal sinuses. According to the classification of World Health Organization, primary adenocarcinomas of the sinonasal tract can be initially classified as salivary and non-salivary types, and non-salivary types are further divided into intestinal and non-intestinal types. The authors experienced a case of papillary intestinal type sinonasal adenocarcinoma of the right nasal cavity in a 59-year-old woman, which was resected successfully via endoscopic approach. We present the clinical characteristics, pathology, treatment, and prognosis of the tumor with a review of the literature.
Adenocarcinoma
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Adenocarcinoma, Papillary
;
Female
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Humans
;
Nasal Cavity
;
Paranasal Sinuses
;
Prognosis
;
World Health Organization
4.Pyoderma Gangrenosum Mimicking Wound Infection after Breast Cancer Surgery
Dabin KIM ; Sung-Mo HUR ; Jae Seok LEE ; Susie CHIN ; Cheol Wan LIM ; Zisun KIM
Journal of Breast Cancer 2021;24(4):409-416
Postoperative pyoderma gangrenosum (PPG) is rare, and its diagnosis is often delayed because of its wound infection-mimicking course. A 53-year-old breast cancer patient who underwent breast-conserving surgery of the right breast presented with fever, leukocytosis, C-reactive protein elevation, and redness of the right breast on postoperative day (POD) 3. The breast wound showed desquamation with painful ulcerative changes from POD 6, and fever was sustained under antibiotic administration. Wound irrigation was attempted; however, inflammatory skin damage progressed to involvement of the entire skin overlying the breast. With clinical suspicion of PPG, skin biopsy and systemic corticosteroid initiation were performed on POD 12. Wound damage progression ceased, and the systemic inflammation subsided. The patient underwent split-thickness skin grafting under intravenous corticosteroid administration, and the wound healed after 30 days. PPG is a rare clinical scenario. Early diagnosis is critical to avoid unnecessary treatment and aggravation of the surgical wound.
5.Malignant rhabdoid tumor of the kidney in an adult with loss of INI1 expression and mutation in the SMARCB1 gene
Eunkyung HAN ; Jiyoon KIM ; Min Jung JUNG ; Susie CHIN ; Sang Wook LEE ; Ahrim MOON
Journal of Pathology and Translational Medicine 2021;55(2):145-153
A 57-year-old man with left flank pain was referred to our institute. Computed tomography scans revealed two enhancing masses in the left kidney. The clinical diagnosis was renal cell carcinoma (RCC). He underwent a radical nephrectomy with an adrenalectomy. Two well-circumscribed solid masses in the hilum and the lower pole (4.5 × 3.5 cm and 7.0 × 4.1 cm) were present. Poorly cohesive uniform round to polygonal epithelioid cells making solid sheets accounted for most of the tumor area. The initial diagnosis was RCC, undifferentiated with rhabdoid features. As the tumor showed loss of INI1 expression and a mutation in the SMARCB1 gene on chromosome 22, the revised diagnosis was a malignant rhabdoid tumor (MRT) of the kidney. To date, only a few cases of renal MRT in adults have been reported. To the best of our knowledge, this is the first report of MRT in the native kidney of an adult demonstrating a SMARCB1 gene mutation, a hallmark of MRT.
6.Pyoderma Gangrenosum Mimicking Wound Infection after Breast Cancer Surgery
Dabin KIM ; Sung-Mo HUR ; Jae Seok LEE ; Susie CHIN ; Cheol Wan LIM ; Zisun KIM
Journal of Breast Cancer 2021;24(4):409-416
Postoperative pyoderma gangrenosum (PPG) is rare, and its diagnosis is often delayed because of its wound infection-mimicking course. A 53-year-old breast cancer patient who underwent breast-conserving surgery of the right breast presented with fever, leukocytosis, C-reactive protein elevation, and redness of the right breast on postoperative day (POD) 3. The breast wound showed desquamation with painful ulcerative changes from POD 6, and fever was sustained under antibiotic administration. Wound irrigation was attempted; however, inflammatory skin damage progressed to involvement of the entire skin overlying the breast. With clinical suspicion of PPG, skin biopsy and systemic corticosteroid initiation were performed on POD 12. Wound damage progression ceased, and the systemic inflammation subsided. The patient underwent split-thickness skin grafting under intravenous corticosteroid administration, and the wound healed after 30 days. PPG is a rare clinical scenario. Early diagnosis is critical to avoid unnecessary treatment and aggravation of the surgical wound.
7.Xanthogranulomatous Osteomyelitis Presenting as a Subacute Infectious Condition in the Fibula of a Young Female
Seong Gyeong JU ; Yu Sung YOON ; Jang Gyu CHA ; Susie CHIN
Investigative Magnetic Resonance Imaging 2023;27(3):163-166
Xanthogranulomatous osteomyelitis is a rare, chronic inflammatory disease characterized by infiltrating lipidized histiocytes, lymphocytes, and plasma cells. Xanthogranulomatous osteomyelitis commonly presents as a mass-like lesion on imaging and may be mistaken for a tumor. Here, we describe an unusual manifestation of xanthogranulomatous osteomyelitis with imaging findings resembling those of Brodie’s abscess, posing a diagnostic challenge in a child. Additionally, we suggest a potential correlation between xanthogranulomatous osteomyelitis and a history of prior trauma.
8.Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.
Hae Il JUNG ; Dongjun JEONG ; Sanghee JI ; Tae Sung AHN ; Sang Ho BAE ; Susie CHIN ; Jun Chul CHUNG ; Hyung Chul KIM ; Moon Soo LEE ; Moo Jun BAEK
Cancer Research and Treatment 2017;49(1):246-254
PURPOSE: Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies. Recently, the overexpression of programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) has been shown to correlate with poor prognosis in many cancers. However, the expression of PD-L1 or PD-1 ligand 2 (PD-L2) and clinical outcomes have not been fully investigated in HCC. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded samples were obtained from 85 patients with HCC who underwent surgery. The expression of PD-Ls (PD-L1, PD-L2) was evaluated by immunohistochemical analysis. RESULTS: The proportion of high expression groups of PD-L1 and PD-L2 was 27.1% and 23.5%, respectively. Univariate analysis revealed that tumor size (p < 0.001), histological differentiation (p=0.010), PD-L1 expression (p < 0.001), and PD-L2 expression (p=0.039) were significant prognostic factors of overall survival in patients with HCC. Multivariate analysis revealed that overall tumor size (hazard ratio [HR], 4.131; 95% confidence interval [CI], 2.233 to 7.643; p < 0.001 and HR, 3.455; 95% CI, 1.967 to 6.067; p < 0.001) and PD-L1 expression (HR, 5.172; 95% CI, 2.661 to 10.054; p < 0.001 and HR, 3.730; 95% CI, 1.453 to 9.574; p=0.006) were independent prognostic values for overall and disease-free survival. Patients with high expression of PD-Ls had a significantly poorer survival than those with low expression (p < 0.001, p=0.034). CONCLUSION: The overexpression of PD-Ls in HCC patients is correlated with survival and tumor recurrence. Further evaluation of PD-1 and PD-Ls as therapeutic targets and predictive biomarkers for HCC is warranted.
Biomarkers
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Carcinoma, Hepatocellular*
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Cell Death
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Disease-Free Survival
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Humans
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Multivariate Analysis
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Prognosis*
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Recurrence
9.A Case of Primary Cutaneous Diffuse Large B-cell Lymphoma,Leg Type Which Metastasized to the Brain.
Yun Mi KIM ; Sung Keun KIM ; Sang Hoon LEE ; Young Lip PARK ; Jongsuk LEE ; Kyu Uang WHANG ; Susie CHIN
Korean Journal of Dermatology 2009;47(10):1149-1153
In the WHO-EORTC (World Health Organization-European Organization for Research and Treatment of Cancer) classification, the primary cutaneous B-cell lymphomas were divided into 4 groups: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center cell lymphoma, primary cutaneous diffuse large B-cell lymphoma, other, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT). PCLBCL LT is known to have more aggressive clinical behavior and a worse prognosis than the other groups of primary cutaneous B-cell lymphomas. We report here on a case of PCLBCL LT in a 55-year-old male who presented witha multiple erythematous nodules on the right leg. After chemotherapy, the skin lesions had almost cleared, but afterward the tumor was revealed to have metastasized to the brain during 1 year.
B-Lymphocytes
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Brain
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Humans
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Leg
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Lymphoma
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Lymphoma, B-Cell
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Lymphoma, B-Cell, Marginal Zone
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Male
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Middle Aged
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Neoplasm Metastasis
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Prognosis
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Skin
;
World Health Organization
10.Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis
Ji-Hye SON ; Jong-Uk LEE ; Susie CHIN ; Eun-Suk GO ; Jai-Seong PARK ; Hwa-Kyun SHIN ; Hun Soo CHANG ; Jong-Sook PARK ; Choon-Sik PARK
The Korean Journal of Internal Medicine 2021;36(4):914-923
Background/Aims:
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction. Because its role has not been evaluated in idiopathic pulmonary fibrosis (IPF), we examined the clinical implications of ROR2 expression.
Methods:
ROR2 mRNA expression was measured using reverse transcription polymerase chain reaction in lung tissue-derived fibroblasts from IPF patients (n = 14) and from controls (n = 10). ROR2 protein was measured using enzyme-linked immunosorbent assay in primary fibroblasts from IPF patients (n = 14) and controls (n = 10), and in bronchoalveolar lavage (BAL) fluids obtained from normal controls (NC; n = 30). IPF patients (n = 84), and other patients with interstitial lung diseases, including nonspecific interstitial pneumonia (NSIP; n = 10), hypersensitivity pneumonitis (HP; n = 10), and sarcoidosis (n = 10).
Results:
ROR2 mRNA and protein levels were significantly higher in IPF fibroblasts than in controls (p = 0.003, p = 0.0017, respectively). ROR2 protein levels in BAL fluids from patients with IPF were significantly higher than in those from NC (p < 0.001), and from patients with NSIP (p = 0.006), HP (p = 0.004), or sarcoidosis (p = 0.004). Receiver operating characteristic curves showed a clear difference between IPF and NC in ROR2 protein level (area under the curve, 0.890; confidence interval, 0.829 to 0.950; p < 0.001). ROR2 protein levels were significantly higher in GAP stage III than in GAP stages I and II (p = 0.016).
Conclusions
ROR2 may be related to the development of IPF, and its protein level may be a useful and severity-dependent candidate marker for IPF.