1.Lack of Rb2/p130 genetic alteration in Malaysian nasopharyngeal carcinoma.
Susan Ling Ling Hoe ; Ee Soo Lee ; Alan Soo Beng Khoo ; Suat-Cheng Peh
The Malaysian journal of pathology 2009;31(1):53-6
The retinoblastoma-related gene Rb2/p130 has been reported to be mutated in several malignancies such as lung cancer and Burkitt's lymphoma. Nasopharyngeal carcinoma (NPC) is a common cancer in Malaysia especially amongst the ethnic Chinese. We screened for Rb2/p130 gene (exons 19 to 21) mutations in 53 archival NPC samples via PCR-SSCP-direct sequencing approach. Only one sample had a base change which involved a serine to glycine substitution at codon 995 (S995G). We conclude that Rb2/p130 genetic alterations are infrequent in NPC and may not be essential for the pathogenesis of the disease.
Genetic
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MALAYSIAN
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Genes
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Carcinoma
;
Malignant Neoplasms
2.Letter 2 regarding “Assessing the performance of ChatGPT in answering questions regarding cirrhosis and hepatocellular carcinoma”
Yiwen ZHANG ; Liwei WU ; Zepeng MU ; Linlin REN ; Ying CHEN ; Hanyun LIU ; Lili XU ; Yangang WANG ; Yaxing WANG ; Susan CHENG ; Yih Chung THAM ; Bin SHENG ; Tien Yin WONG ; Hongwei JI
Clinical and Molecular Hepatology 2024;30(1):113-117
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