1.Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel
Ren SAN ; Weidong YUE ; Surong HASI
Journal of Veterinary Science 2019;20(3):e12-
The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen only or with the enzyme inhibitor lomefloxacin. Blood samples were collected after different intervals, and p-acetaminophen concentration was determined by high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by Phoenix WinNonLin v.7.0. The results show that lomefloxacin can significantly inhibit Bactrian camel CYP1A enzyme, as evidenced by the prolonged elimination half-life, increased maximum plasma concentration and area under the curve values and the shortened time to peak concentration for p-acetaminophenol in the substrate with inhibitor group. The results lay a foundation for revealing the particular characteristics of the CYP1A enzyme in Bactrian camels.
Camels
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Chromatography, Liquid
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Half-Life
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Pharmacokinetics
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Plasma
2.Image identification for microscopic structures of Mongolian herbal flowers with invariant moments.
Surong HASI ; Guleng AMU ; Luyan GAO ; Shisan QI
Journal of Biomedical Engineering 2008;25(1):146-149
Microscopic characteristics of several Mongolian Herbal flowers were extracted by improved Pseudo-Jacobi (p = 4, q = 2)-Fourier Moments (PJFM's), and 368 different versions of 28 microscopic characteristics of these herbs were identified by using the minimum-mean-distance rule. The experimental results showed that the average identification rate reaches as high as 98.1%. Therefore, this study can provide new techniques for digitalization and visualization of microscopic characteristics of Mongolian Herbs.
China
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Flowers
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ultrastructure
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Image Processing, Computer-Assisted
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methods
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Pattern Recognition, Automated
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methods
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Plants, Medicinal
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ultrastructure