No abstract available.
Frontotemporal Dementia ; Serotonin ; Supranuclear Palsy, Progressive

Purposeless groaning has been reported in advanced progressive supranuclear palsy. We present a case of purposeless groaning occurring as a primary complaint in a patient with advanced Parkinson's disease. Purposeless groaning is thought to be a manifestation of disinhibition and perseveration due to frontal-subcortical dysfunction. Proper recognition of this phenomenon will help clinicians to avoid unnecessary investigations and treatment (e.g., prescription of opioid medications).
Humans ; Parkinson Disease ; Prescriptions ; Supranuclear Palsy, Progressive

Humans ; Supranuclear Palsy, Progressive ; Acupuncture Therapy

No abstract available.
Aphasia, Primary Progressive ; Frontotemporal Dementia ; Supranuclear Palsy, Progressive

We have experienced a rare case of progressive supranuclear palsy with hallucination and delusion. The common manifestations of progressive supranuclear palsy are gait disturbance, mental change and sign of vertical ophthamoplegia but no efficacious therapy has been known. Neuropsychiatric symptom clusters include cognitive impairment, affective and behavioral changes, sleep disturbance, and psychotic symptoms. Though schizophrenia-like psychosis has been reported but this is certainly rare. Addressing a case of progressive supranuclear palsy, in whom parkisonian symptoms appeared with concurrent psychotic symptoms, we emphasize accurate diagnosis.
Delusions ; Diagnosis ; Gait ; Hallucinations ; Psychotic Disorders ; Supranuclear Palsy, Progressive*

Pretarsal motor persistence (PMP), a subtype of apraxia of the eyelid opening, is characterized by the inability to open the eyelids at will due to persistent activity of orbicularis oculi muscles following voluntary closure. Here, we describe clinical characteristic and the synchronous EMG recording from the levator palpebrae and orbicularis oculi muscles of PMP in patient with essential blepharospasm, idiopathic Parkinson's disease, and progressive supranuclear palsy.
Apraxias ; Blepharospasm ; Eyelids ; Humans ; Muscles ; Parkinson Disease ; Supranuclear Palsy, Progressive

No abstract available.
Frontotemporal Dementia ; Postural Orthostatic Tachycardia Syndrome* ; Supranuclear Palsy, Progressive

BACKGROUND: Tauopathies are a group of diseases caused by the accumulation of hyperphosphorylated tau protein in the central nervous system. Previous studies have revealed that there is considerable overlap in clinical, pathological, and genetic features among different taupathies. CASE REPORT: We report a patient with non-fluent/agrammatic primary progressive aphasia at the initial assessment. Over time, other symptoms belonging to corticobasal degeneration and progressive supranuclear palsy appeared in this patient. CONCLUSIONS: Clinical overlapping features in these disorders may represent different phenotypes of a single disease process.
Aphasia, Primary Progressive* ; Central Nervous System ; Humans ; Phenotype ; Supranuclear Palsy, Progressive ; tau Proteins ; Tauopathies

Progressive supranuclear palsy (PSP) is a clinical syndrome comprising vertical supranuclear palsy, parkinsonism, postural instability, and mild dementia. Other disorders can present with similar clinical pictures. In this report we describe a case of Creutzfeldt-Jakob disease (CJD) presenting with the PSP and discuss which features may help to prevent misdiagnosis. To the best of our knowledge, this is the first report of CJD presenting with PSP syndrome in Korea.
Creutzfeldt-Jakob Syndrome* ; Dementia ; Diagnostic Errors ; Korea ; Paralysis ; Parkinsonian Disorders ; Supranuclear Palsy, Progressive*

PURPOSE: To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiating idiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios. MATERIALS AND METHODS: Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of 135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions of interest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. ESULTS: NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 +/-0.26 versus 1.45 +/-0.20, and 1.26 +/-.23 versus 1.38 +/-0.19, respectively : p<0.05). NAA/Cho and NAA/Cr ratios were significantly lower inage-matched controls than in younger normal controls (1.39 +/-0.21 versus 1.76 +/-0.15, and 1.36 +/-0.13 versus1.79 +/-0.17, respectively : p<0.05). However, NAA/Cho and NAA/Cr ratios between age-matched controls and IPD werenot significantly different (p>0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients. CONCLUSION: NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSP group than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differential diagnosis of IPD and PSP.
Corpus Striatum ; Humans ; Lactic Acid ; Magnetic Resonance Spectroscopy* ; Neurons ; Parkinson Disease* ; Putamen ; Steam ; Supranuclear Palsy, Progressive*