1.Chinese herbal medicine reduces mortality in patients with severe and critical Coronavirus disease 2019: a retrospective cohort study.
Guohua CHEN ; Wen SU ; Jiayao YANG ; Dan LUO ; Ping XIA ; Wen JIA ; Xiuyang LI ; Chuan WANG ; Suping LANG ; Qingbin MENG ; Ying ZHANG ; Yuhe KE ; An FAN ; Shuo YANG ; Yujiao ZHENG ; Xuepeng FAN ; Jie QIAO ; Fengmei LIAN ; Li WEI ; Xiaolin TONG
Frontiers of Medicine 2020;14(6):752-759
This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20, 2020. All patients were divided into an exposed group (CHM users) and a control group (non-users). After propensity score matching in a 1:1 ratio, 156 CHM users were matched by propensity score to 156 non-users. No significant differences in seven baseline clinical variables were found between the two groups of patients. All-cause mortality was reported in 13 CHM users who died and 36 non-users who died. After multivariate adjustment, the mortality risk of CHM users was reduced by 82.2% (odds ratio 0.178, 95% CI 0.076-0.418; P < 0.001) compared with the non-users. Secondly, age (odds ratio 1.053, 95% CI 1.023-1.084; P < 0.001) and the proportion of severe/critical patients (odds ratio 0.063, 95% CI 0.028-0.143; P < 0.001) were the risk factors of mortality. These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19.
Age Factors
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Aged
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COVID-19/therapy*
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China
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Drugs, Chinese Herbal/therapeutic use*
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Female
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Humans
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Male
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Medicine, Chinese Traditional
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Middle Aged
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Odds Ratio
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Propensity Score
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Retrospective Studies
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Survival Rate
Result Analysis
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