1.β-Adrenergic Receptor and Insulin Resistance in the Heart.
Supachoke MANGMOOL ; Tananat DENKAEW ; Warisara PARICHATIKANOND ; Hitoshi KUROSE
Biomolecules & Therapeutics 2017;25(1):44-56
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Over-stimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR over-stimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs over-stimulation leads to induction of insulin resistance in the heart.
Cardiovascular Diseases
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Cyclic AMP-Dependent Protein Kinases
;
Glucose
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Heart Diseases
;
Heart Failure
;
Heart*
;
Humans
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Insulin Resistance*
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Insulin*
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Mortality
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Myocardium
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Sympathetic Nervous System
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Up-Regulation
2.Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Motohiro NISHIDA ; Tomohiro TANAKA ; Supachoke MANGMOOL ; Kazuhiro NISHIYAMA ; Akiyuki NISHIMURA
Journal of Lipid and Atherosclerosis 2020;9(1):124-139
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response to changes in the vessel environment. Abnormal phenotypic switching of VSMCs is a distinctive characteristic of vascular disorders, including atherosclerosis, pulmonary hypertension, stroke, and peripheral artery disease; however, how the control of VSMC phenotypic switching is dysregulated under pathological conditions remains obscure. Canonical transient receptor potential (TRPC) channels have attracted attention as a key regulator of pathological phenotype switching in VSMCs. Several TRPC subfamily member proteins—especially TRPC1 and TRPC6—are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. This review summarizes the current understanding of the role of TRPC channels in cardiovascular plasticity, including our recent finding that TRPC6 participates in aberrant VSMC phenotype switching under ischemic conditions, and discusses the therapeutic potential of TRPC channels.