PURPOSE: The purpose of this study was to systematically review the suicide prevention programs for healthcare personnel to identify contents, formats, and strategies essential for effective suicide prevention programs. METHODS: A systematic search using key words in English and Korean was conducted using 10 electronic databases, including EMBASE, MEDLINE, and RISS. Of 794 publications identified, 9 studies were finally included in this systematic review. The Scottish Intercollegiate Guidelines Network (SIGN) was used for the quality assessment. RESULTS: Of the nine experimental studies, seven studies used randomized controlled trials (RCTs), and two used quasi-experimental designs. Overall, suicide prevention programs were found to be effective in improving competencies (e.g., knowledge, communication skills, and attitudes) of healthcare personnel working in diverse settings. Limitations of these studies included a lack of rigorous research designs and reliable and universal outcome measures. Paradoxically, none of the studies were conducted in South Korea, which consistently has the highest suicide rate of all OECD countries. CONCLUSION: Suicide prevention programs for health personnel can be an effective way to improve competency of healthcare personnel in preventing suicide. These findings will serve as a foundation for the development of suicide prevention programs by Korean healthcare personnel.
Delivery of Health Care* ; Health Personnel ; Humans ; Korea ; Organisation for Economic Co-Operation and Development ; Outcome Assessment (Health Care) ; Research Design ; Suicide*

Purpose: The present study was conducted to develop the Life Respect Enhancement Program and test its effectiveness on suicide knowledge, suicide intervention skills, self-efficacy in suicide prevention, and gatekeeper behaviors among nursing officers. Methods: The program was developed according to the ADDIE model and finalized after practical need analysis, expert verification, and a preliminary study.The present study used a concurrent embedded mixed-method research design. To compare the effects of the Program and the control group on the outcome variables, a quantitative study was conducted using a nonequivalent control group with a pretest-posttest design.Quantitative data were analyzed using c 2 -tests, t-tests, and RM-ANOVA. A qualitative study was conducted using FGI with six members of the experimental group 3 months after intervention completion. Results: In total, 56 nursing officers participated in the 3-month follow-up test. Compared to the control group, the experimental group showed significant improvements in suicide knowledge, suicide intervention skills, and self-efficacy in suicide prevention scores at post-test. The significant group differences in suicide knowledge and suicide intervention skills were maintained at 3 months. The gatekeeper behavior scores of the experimental group were also significantly higher than those of the control group at 3 months. Qualitative analysis of the participants’ experiences with the Program yielded two themes and seven sub-themes. Conclusion The newly developed Life Respect Enhancement Program demonstrates significant effects on suicide knowledge, suicide intervention skills, and gatekeeper behaviors. Thus, this program is recommended to promote suicide prevention competencies among nursing officers in military clinical settings.

Aptamers are synthetic, relatively short (e.g., 20-80 bases) RNA or ssDNA oligonucleotides that can bind targets with high affinity and specificity, similar to antibodies, because they can fold into unique, three-dimensional shapes. For use in various assays and experiments, aptamers have been conjugated with biotin or digoxigenin to form complexes with avidin or anti-digoxigenin antibodies, respectively. In this study, we developed a method to label the 5' ends of aptamers with cotinine, which allows formation of a stable complex with anti-cotinine antibodies for the purpose of providing another affinity unit for the application in biological assays using aptamers. To demonstrate the functionality of this affinity unit in biological assays, we utilized two well-known aptamers: AS1411, which binds nucleolin, and pegaptanib, which binds vascular endothelial growth factor. Cotinine-conjugated AS1411/anti-cotinine antibody complexes were successfully applied to immunoblot, immunoprecipitation, and flow cytometric analyses, and cotinine-conjugated pegaptanib/anti-cotinine antibody complexes were used successfully in enzyme immunoassays. Our results show that cotinine-conjugated aptamer/anti-cotinine antibody complexes are an effective alternative and complementary technique for aptamer use in multiple assays and experiments.
Animals ; Antibodies, Anti-Idiotypic/immunology/metabolism ; *Aptamers, Nucleotide/chemistry/immunology ; Biological Assay ; *Cotinine/administration & dosage/chemistry ; Flow Cytometry ; Hep G2 Cells ; Humans ; Mice ; NIH 3T3 Cells ; Phosphoproteins/*chemistry/immunology ; Protein Binding ; RNA-Binding Proteins/*chemistry/immunology ; *Vascular Endothelial Growth Factor A/chemistry/immunology

OBJECTIVES: This study aimed to identify the differences and the profiles of cognitive deficits in remitted patients with schizophrenia and first-degree relatives of schizophrenic probands. METHODS: A total of 26 remitted states of schizophrenia patients were included in the study and the same number of unaffected first-degree relatives of schizophrenic probands and healthy controls were matched for age, sex, years of education. Cognitive function of all participants was measured by using the Digit span test, the Continuous performance test, the Rey auditory & visual learning test, the Complex figure test, the Verbal fluency test, the Wisconsin card sorting test and the Finger tapping test. The effects of subsyndromal symptomatology and general intelligence score were controlled. RESULTS: Schizophrenia patients' group showed more significant impairment than other groups in verbal memory (learning, immediate recall, delayed recall), visual memory (copy, immediate recall, delayed recall) and cognitive flexibility domains. The family group and the patient group commonly performed significantly worse than healthy controls in working memory and verbal fluency (category) tests. There were no differences in sustained attention, psychomotor performance. CONCLUSIONS: Our research shows that the deficit in working memory and verbal fluency could be strong candidates of endophenotypic marker in schizophrenia.
Education ; Endophenotypes ; Fingers ; Humans ; Intelligence ; Learning ; Memory ; Memory, Short-Term ; Pliability ; Psychomotor Performance ; Schizophrenia* ; Wisconsin

OBJECTIVES: To compare the clinical effectiveness of the virtual reality (VR) programs in assessing psychosocial problems, improving symptoms, and reducing suicide risk in depressive patients with those of pharmacotherapy. METHODS: Thirty-six patients were recruited with depression in the treatment group and 22 participants in the healthy control group through internet advertisements between November 2018 and March 2019. Participants in the treatment group were allocated randomly at a 1:1 ratio to either the VR group or pharmacotherapy group. At the baseline, all participants were assessed with a comprehensive battery for their psychological characteristics by structured scales using VR technologies. Assessments of patients in the treatment group were repeated four weeks after therapeutic intervention. The primary outcome measures were the Korean Version of Quick Inventory of Depressive Symptomatology-Self-Report and suicidality scales of the Korean Mini International Neuropsychiatric interview. The borderline personality (Personality Assessment Inventory-Borderline Features Scale) and resilience (Korean Resilience Questionnaire) were also evaluated. RESULTS: Twenty-four depressive patients completed the treatment, and the final assessment was conducted after four weeks of treatment. In the initial assessment, the patient group showed significantly higher depressive symptoms, suicidality, borderline personality trait, and lower resilience than healthy control group. After the four-week therapeutic interventions, the VR group showed significant improvement in depression, suicidality, borderline personality trait, and resilience. In addition, there was no significant difference in the treatment efficacy between the VR group and the pharmacotherapy group. CONCLUSION In this study, the VR treatment program has clear benefits for emotional distress and reducing suicidality in depressive patients. Evidence-based VR treatments may show new clinical potential for depressive disorder.

As South Korea transitions into a super-aged society, addressing the challenges of aging through tailored nutritional strategies is becoming increasingly critical. This study developed a hemp seed soup designed for the elderly, using the functional benefits of hemp, a nutrient-dense ingredient rich in dietary proteins, essential fatty acids, polyphenols, and antioxidants. Soups were formulated with varying levels of hemp seed powder (0% (CS), 25% (HS25S), 50% (HS50S), and 75% (HS75S)), to address the dietary needs and physiological characteristics of the elderly, including mastication and swallowing difficulties. Increasing the hemp seed powder levels significantly enhanced the crude protein, total polyphenol, and flavonoid contents while improving the antioxidant activities, as assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. HS75S exhibited the highest nutritional values and antioxidant activity. By contrast, food texture analysis showed that the viscosity decreased at higher hemp seed concentrations, with HS25S and HS50S demonstrating favorable textures for elderly consumption.Consumer acceptance testing identified HS50S as the most preferred sample, scoring highest in flavor, texture, and overall acceptability. This study highlights the potential of hemp seeds as a functional ingredient in developing nutritious and elderly-friendly food products. The hemp seed soup, with its enhanced protein, antioxidant properties, and tailored texture, offers a promising solution to improve the nutritional status and health of the elderly. Future studies should explore the long-term health benefits of hemp seed soup and its integration with other functional ingredients to optimize the sensory and nutritional properties.

As South Korea transitions into a super-aged society, addressing the challenges of aging through tailored nutritional strategies is becoming increasingly critical. This study developed a hemp seed soup designed for the elderly, using the functional benefits of hemp, a nutrient-dense ingredient rich in dietary proteins, essential fatty acids, polyphenols, and antioxidants. Soups were formulated with varying levels of hemp seed powder (0% (CS), 25% (HS25S), 50% (HS50S), and 75% (HS75S)), to address the dietary needs and physiological characteristics of the elderly, including mastication and swallowing difficulties. Increasing the hemp seed powder levels significantly enhanced the crude protein, total polyphenol, and flavonoid contents while improving the antioxidant activities, as assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. HS75S exhibited the highest nutritional values and antioxidant activity. By contrast, food texture analysis showed that the viscosity decreased at higher hemp seed concentrations, with HS25S and HS50S demonstrating favorable textures for elderly consumption.Consumer acceptance testing identified HS50S as the most preferred sample, scoring highest in flavor, texture, and overall acceptability. This study highlights the potential of hemp seeds as a functional ingredient in developing nutritious and elderly-friendly food products. The hemp seed soup, with its enhanced protein, antioxidant properties, and tailored texture, offers a promising solution to improve the nutritional status and health of the elderly. Future studies should explore the long-term health benefits of hemp seed soup and its integration with other functional ingredients to optimize the sensory and nutritional properties.

As South Korea transitions into a super-aged society, addressing the challenges of aging through tailored nutritional strategies is becoming increasingly critical. This study developed a hemp seed soup designed for the elderly, using the functional benefits of hemp, a nutrient-dense ingredient rich in dietary proteins, essential fatty acids, polyphenols, and antioxidants. Soups were formulated with varying levels of hemp seed powder (0% (CS), 25% (HS25S), 50% (HS50S), and 75% (HS75S)), to address the dietary needs and physiological characteristics of the elderly, including mastication and swallowing difficulties. Increasing the hemp seed powder levels significantly enhanced the crude protein, total polyphenol, and flavonoid contents while improving the antioxidant activities, as assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. HS75S exhibited the highest nutritional values and antioxidant activity. By contrast, food texture analysis showed that the viscosity decreased at higher hemp seed concentrations, with HS25S and HS50S demonstrating favorable textures for elderly consumption.Consumer acceptance testing identified HS50S as the most preferred sample, scoring highest in flavor, texture, and overall acceptability. This study highlights the potential of hemp seeds as a functional ingredient in developing nutritious and elderly-friendly food products. The hemp seed soup, with its enhanced protein, antioxidant properties, and tailored texture, offers a promising solution to improve the nutritional status and health of the elderly. Future studies should explore the long-term health benefits of hemp seed soup and its integration with other functional ingredients to optimize the sensory and nutritional properties.

OBJECTIVE: Few studies have focused on the characteristic features of drug overdose in children and adolescents who have attempted suicide in Korea. The present study examined the characteristics of drug overdose in children and adolescents who visited the emergency room following drug ingestion for a suicide attempt. METHODS: The medical records of 28 patients who were treated in the emergency room following a drug overdose from January 2008 to March 2011 were analyzed. Demographic and clinical variables related to the suicide attempts were examined. RESULTS: The mean age of the patients was 16.6+/-1.7 years (range 11-19 years), and 20 of the patients (71.4%) were female. Most of the patients (n=23, 82.1%) overdosed on a single drug; acetaminophen-containing analgesics were the most common (n=12, 42.9%). Depression was the most common psychiatric disorder (n=22, 78.6%), and interpersonal conflict was the most common precipitating factor of the suicide attempts (n=11, 39.3%). This was the first suicide attempt for approximately 80% of the patients. About one fourth of the patients (n=7, 25%) had follow-up visits at the psychiatric outpatient clinic. CONCLUSION: Early screening and psychiatric intervention for depression may be an important factor in preventing childhood and adolescent suicide attempts. Developing coping strategies to manage interpersonal conflicts may also be helpful. Moreover, policies restricting the amount and kind of drugs purchased by teenagers may be necessary to prevent drug overdose in this age group.
Adolescent ; Analgesics ; Child ; Depression ; Drug Overdose ; Eating ; Emergencies ; Female ; Follow-Up Studies ; Humans ; Korea ; Mass Screening ; Medical Records ; Outpatients ; Precipitating Factors ; Suicide ; Suicide, Attempted