BACKGROUND: A lot of protective tools such as sunshades (sun-cap), sun-shielding tints and various sunscreens are widely used to protect solar ultraviolet (UV) radiation. Although dermatologists are aware of these products, they do not know the exact protective efficacy or their stability after strong UV irradiation. OBJECTIVE: We tried to measure the spectal absorbance and transmittance of various sunscreening products. In addition, we measured change of sunscreens's absorbance or transmittance after strong UV irradiation for 30, 60 and 90 minutes. METHODS: We purchased five commercially available sunshades (product A-E), five sun-tinting films (product A-E), and eight sunsceens (product A-H) with similar sun-protection factor (SPF) around 30, and measured spectral absorbance and transmittance of those agents. For the sunscreens, they were irradiated with 250 watt Xenon-Arc lamp and change of spectral responses were evaluated. RESULTS: In absorption and transmission spectra of five different sun-caps, sun-cap C showed very good protection in entire UV range whereas all others protected UV only partially. Absorption and transmission spectra of six different sun-shielding tints showed all of them protected UV fairly well and tint C showed the best protection. Eight different sunscreens showed profound differences in spectal absorbances or transmittances. Sunscreen-A showed the best protection and there was no relationship between price and spectral-protection of sunscreens. In the photo-stability of eight sunscreens after UV-irradiation, there were big differences. Only sunscreen-A showed the least change after UV irradiation, and all other sunscreens showed a change of specta by increased UV-irradiation time. CONCLUSION: Protection efficacies of sunscreening products were variable, and most sunscreens were unstable to strong UV irradiation. Further studies would be necessary to give proper information for protecting UV effectively to dermatologists and consumers.
Absorption ; Sunscreening Agents

BACKGROUND: Recently, concerns regarding protection provided by sunscreens in the UVA spectrum have been raised. But there is no standard testing protocol for quantifying this protection. OBJECTIVE: As an ideal test methodology, the PFA test using the concept of minimal pigment darkening dose(MPPD) was evaluated to determine its ability to quantify the UVA protection provided by a sunscreen. METHODS: Sunscreen products were tested on unsensitized women subjects with both UVA from a Sellas UVA lamp in a protocol similar to the sun protection factor test(SPF) and UVB by the SPF protocol. RESULTS: The protection factors in UVA ranged from 5.0 to 5.3 depending on the type of absorber and the UVB blocking filter. CONCLUSION: This test method provides a realistic in vivo estimate of the amount of UVA protection provided by sunscreens.
Female ; Humans ; Sun Protection Factor ; Sunscreening Agents*

BACKGROUND: Human repeated insult patch tests (HRIPTs) are a final method for safety assessment of chemical ingredients. In the representative HRIPTs, the Shelanski and modified Draize require 200 participants, but the maximization and modified maximization tests require only 25. OBJECTIVE: To evaluate the safety of three sunscreen ingredients using the Shelanski and maximization methods. METHODS: Octylmethoxycinnamate, butylmethoxydibenzoylmethane, and octyltriazone (BASF) were prepared for the induction, as 25% ointment in white petrolatum base. After a 2-3 week resting phase, patch and photopatch tests were conducted, but pretreatment with SLS was only performed in the maximization test. The results were analyzed using the Chi-Square test. RESULTS: During the induction phase, there were only two (4%) weak positive reactions observed with the Shelanski method, whereas all 25 displayed strong or extremely positive reactions with the maximization method. Butylmethoxydibenzoylmethane displayed the most frequent elicitation reactions; the patch and photopatch tests displayed weak positive reactions in four (2%) and six (3%), and in one (4%) and two (8%), with the Shelanski and maximization tests, respectively. Taking into account two of the six reactors displayed positive reactions to petrolatum with the Shelanski test, the actual number of positive patch test reactions would be four (2%). The difference in results of the two methods was not statistically significant. CONCLUSION: Although it is not easy to conduct HRIPT on 200 subjects, and the results from the two tests were not significantly different, the reactions from the maximization tests were too severe to be recommended in humans.
G0 Phase ; Humans* ; Patch Tests* ; Petrolatum ; Photosensitivity Disorders ; Sunscreening Agents*

RATIONALE

Skin cancer is the most common cancer in fair-skinned populations. Overall, strategies focus on modifiable risk factors such as reducing ultraviolet (UV) radiation exposure through physical, topical or systemic protection. Currently, data on knowledge, attitude and practices of Filipino patients on UV index in relation to sun protection is unavailable.

The objective of this study is to improve sunscreen use among patients seen in a tertiary hospital in Manila, specifically after UV index education.

The study will be conducted among patients at the outpatient department of the University of Santo Tomas Hospital, Department of Dermatology, after UV index education. Patients who will be included are aged 18 to 65 years old, belonging to both sexes and able to understand English or Filipino. The exclusion criteria includes children, elderly greater than the age of 65, prisoners, mentally handicapped or those with incurable diseases.

3 weeks 

The outcome is the improvement in sunscreen use among patients seen in a tertiary hospital in Manila, specifically after UV index education.

BACKGROUND

Acne patients often use medications, either over the counter or prescribed by dermatologists, to manage their condition. Dermatologists frequently include sunscreens as part of these treatment plans alongside acne medications. This research aims to determine the level of knowledge, attitudes, and practices regarding sunscreen use among respondents who are confirmed acne patients and have been prescribed sunscre-en as part of their treatment regimen.

This research examines the current knowledge, attitudes, and practices of acne patients regarding sunscreen use as part of their acne t reatment regimen, considering demographic factors. The knowledge, attitudes, and practices of the respondents will be compared across different age groups, genders, and employment statuses.

This study purposefully collected data from patients with active acne on the use of sunscreens alongside acne medications. The sample included males and females aged 18-27, 28-40, and 40+ residing in either the National Capital Region or the CALABARZON Region, with 105 respondents in each group. Data was gathered using a validated Knowledge, Attitudes, and Practices (KAP) questionnaire, consisting of 30 questions that had undergone reliability testing via Cronbach's alpha. Responses were recorded on a 3-point Likert scale to model the interaction of KAP variables. The research material was distributed through Google Forms in June 2024. Data analysis was conducted using R, specifically the psych package, and the Kruskal-Wallis test was applied to compare groups, determining if significant differences existed among them. This test was incorporated within RStudio.

Findings indicated that respondents generally demonstrated a high level of understanding regarding the importance of sunscreen when used alongside acne treatments, particularly acknowledging its role in preventing acne scarring and reducing skin sensitivity caused by treatment products. Additionally, attitudes toward sunscreen use were largely positive, with respondents rejecting common misconceptions about sunscreen. However, actual sunscreen application practices were moderate, with adherence levels varying across the sample. Significant differences in sunscreen use were observed based on employment status, gender, and age.

Acne patients in this study had a high level of knowledge and a positive attitude on the use of sunscreen together with their acne medications. consistency in sunscreen application was moderate. unemployed respondents were more receptive to external influences regarding sunscreen use. Female respondents were more informed and proactive than male respondents. Younger respondents were more influenced by social networks. This research highlights the need for continued education on the benefits of sunscreen use to be able to achieve an effective acne vulgaris management.

BACKGROUND: The need for using sunscreen is increasing today, but we know little about the effect of sunscreens on the skin of Korean people. OBJECTIVE: We tried to estimate and compare the SPF of 8% homomenthyl salicylate lotion, which was recommended as the control in SPF experiments by the FDA, USA, in Koreans according to different light sources. METHODS: After application of 8% homomenthyl salicylate lotion to the back, 33 men of the third decade were irradiated by xenon arc solar simulator or by fluorescent sunlamp, We estimated the SPF of them 24 hours later. RESULTS: The SPF of 8% homomenthyl salicylate lotion was 4.8+/-0.8 with the solar simulator, 2.7+/-0.6 with the fluorescent sunlamp. CONCLUSION: We confimed that the SPF of 8% homomenthyl salicylate lotion with xenon arc solar simulator can be used as a control value in Koreans, and found out that the SPF with the fluorescent sunlamp was significantly lower than that with the xenon arc lamp. So it should be taken into consideration that differences of SPF according to light sources exists in studying sunscreens.
Humans ; Male ; Skin ; Solar System* ; Sun Protection Factor* ; Sunscreening Agents ; Xenon

BACKGROUND: The need for using sunscreen is increasing today, but we know little about the effect of sunscreens on the skin of Korean people. OBJECTIVE: We tried to estimate and compare the SPF of 8% homomenthyl salicylate lotion, which was recommended as the control in SPF experiments by the FDA, USA, in Koreans according to different light sources. METHODS: After application of 8% homomenthyl salicylate lotion to the back, 33 men of the third decade were irradiated by xenon arc solar simulator or by fluorescent sunlamp, We estimated the SPF of them 24 hours later. RESULTS: The SPF of 8% homomenthyl salicylate lotion was 4.8+/-0.8 with the solar simulator, 2.7+/-0.6 with the fluorescent sunlamp. CONCLUSION: We confimed that the SPF of 8% homomenthyl salicylate lotion with xenon arc solar simulator can be used as a control value in Koreans, and found out that the SPF with the fluorescent sunlamp was significantly lower than that with the xenon arc lamp. So it should be taken into consideration that differences of SPF according to light sources exists in studying sunscreens.
Humans ; Male ; Skin ; Solar System* ; Sun Protection Factor* ; Sunscreening Agents ; Xenon

BACKGROUND: Solar ultraviolet (UV) radiation induces sunburn, immune suppression, and various pigmentary disorders. Sunscreens are widely used to protect those untoward effects by UV but there are reports of phototoxicity or stability problems of sunscreens after exposure to UV. OBJECTIVE: We tried to compare sunscreens with different photostability in terms of their protection against various biologic responses like sunburn, immune suppression or pigmentation. METHODS: Three different sunscreens with SPF around 30 were used; Sunscreen-A (Sc-A) was photochemically inert, sunscreen-B (Sc-B) showed intermediate level of photostability, and sunscreen-C (Sc-C) was the least stable. To observe their in vivo effects, we measured sunscreen-protection against sunburn by back-skin swelling and sunburn cell formation, against immune suppression measured by depletion of Langerhans cells, local and systemic suppression of contact hypersensitivity (CHS), and against pigmentation by irradiation with mixed light source with UVA and UVB lamps that mimic solar UV spectrum. RESULTS: Back skin swellings by 5 kJ/m2 of UVB were protected well by sunscreens, but protection of Sc-C against 50 kJ/m2 of UVB was worse than Sc-A or Sc-B. Sunburn cells were increased significantly in mice irradiated with 5 kJ/m2 of UVB and it was protected by sunscreens, and the effect of photostability was minimal. Depletion of epidermal Langerhans cells by 5 kJ/m2 of UVB was protected completely by sunscreens. Local suppression of CHS by 5 kJ/m2 of UVB was protected by sunscreens, and Sc-A had better protection. But, in the experiment with 50 kJ/m2 of UVB, the protective efficacy was reversed; Sc-A showed worse protection. Systemic suppression of CHS by 10 kJ/m2 of UVB was protected well by sunscreens, and Sc-A had better protection and Sc-C had worse protection. In the experiment irradiated with 100 kJ/m2 of UVB, the protection of sunscreens was decreased, and Sc-B showed better protection, whereas Sc-C showed worse protection. In UV-induced pigmentation, all three sunscreens showed significant protection both by L* value and individual topographic angle (ITA) with the best protection by Sc-A and the worst protection by Sc-B. CONCLUSION: These data showed sunscreens can protect various in vivo responses and photostability of sunscreens played important roles particularly in the back-skin swelling and systemic suppression of CHS by high dose of UVB.
Animals ; Dermatitis, Contact ; Dermatitis, Phototoxic ; Langerhans Cells ; Mice ; Pigmentation ; Skin ; Sunburn ; Sunscreening Agents*

The purpose of this study is to evaluate the effectiveness of these para-amino- benzoate, benzophenone and cinnamate sunscreens in the same base(cream) and the effect of concentration on sun protection with three different concentrations(2 5%, 5. 0% and 7. 5%.). Twenty-one normal healthy Korean-men, majority(2. 5%) of whom have skin type iv or v, were applied to their untanned back with above prepared nine different sunscreens and calculated individual sun protection factor (SPF) of these different sunscreens. The test results can be summarized as follows: 1. In the para-aminobenzoic acid, the mean SPF, of concentrations were 7. 33+2. 87, 7.35+2. 89 and 7. 37+2. 88 no significant difference. 2. In the benzophenone, the mean SPF of all of 2. 5M, ntrations was 3.43 t0. 85. 3 In the cinnamate, the mean SPF of all of 2. 5% 5. O%
4-Aminobenzoic Acid ; Benzoates ; Skin* ; Solar System ; Sun Protection Factor ; Sunscreening Agents*

The sunscreening effect can be varied according to the vehicles. Therefore the purpose of this study is to compare the effect of vehicles(bases) on sun protection in p-aminobenzoic acid, cinnamate and benzophenone sunscreens with same concentration (2.5%), We included ointment (white petrolatum), cream (hydrophilic), milky lotion and alcohol as the sunscreen vehicles. The test results can be summarized as follows: We could not recognize a sunscreening effect of sunscreen vehicles which did not contain sunscreening agent. In the case of p-aminobenzoic acid, the mean sun protection factor was higher in the sequence of cream, milky lotion, alcohol, ointment, each showing 9, 95+/-3.67, 8.09+/-2.56, 5.14+/-1.45, 4.35+/-1.46 respectively. In the case of cinnamate, the mean sun protection factor was higher in the sequence of cream, ointment, milky lotion, alcohol, each showing 6 46+/-1.89, 5.42+/-1.49, 4.82+/-1.84, 4.05+/-1.45 respectively. 4. In the case of benzophenone, the mean sun protection factor was higher in the sequence of cream, alcohol, ointment, milky lotion, each showing 5 .26+/-1.56, 4.94+/-1.24, 4.56+/-1.71, 4.18+/-1.23 respectively.
4-Aminobenzoic Acid ; Skin* ; Solar System ; Sun Protection Factor ; Sunscreening Agents