We report a case of glomerular disease with both mesangial IgA and subepithelial IgG deposits in the allograft kidney. The patient was a 36 year-old man who had received a renal allograft 1 year previously. Fifteen days before admission, he discovered a microscopic hematuria without clinical evidences of allograft rejection. Light microscopy showed diffuse increase of mesangial matrix without mesangial cell proliferation. Capillary walls were diffusely and mildly thickened. Immunofluorescence microscopy demonstrated both granular deposits of IgA in the mesangium and IgG along the capillary walls. On electron microscopy, electron-dense deposits were identified not only in the mesangium but also on the epithelial side of the glomerular basement membrane.
Adult ; Case Report ; Glomerulonephritis, IGA/*immunology/pathology ; Human ; Immunoglobulin A/*analysis ; Immunoglobulin G/analysis ; Kidney/*immunology/pathology ; Kidney Transplantation/*immunology ; Male ; Transplantation, Homologous

BACKGROUND: Although surgical resection with chemotherapy is considered effective for patients with advanced gastric cancer, it remains the third leading cause of cancer-related death in South Korea. Several studies have reported that mesothelial markers including mesothelin, calretinin, and Wilms tumor protein 1 (WT1) were positive in variable carcinomas, associated with prognosis, and were evaluated as potential markers for targeted therapy. The aim of this study was to assess the immunohistochemical expression of mesothelial markers (mesothelin, calretinin, and WT1) in gastric adenocarcinoma and their relations to clinocopathological features and prognosis. METHODS: We evaluated calretinin, WT1, and mesothelin expression by immunohistochemical staining in 117 gastric adenocarcinomas. RESULTS: Mesothelin was positively stained in 30 cases (25.6%). Mesothelin expression was related to increased depth of invasion (p = .002), lymph node metastasis (p = .013), and presence of lymphovascular (p = .015) and perineural invasion (p = .004). Patients with mesothelin expression had significantly worse disease-free survival rate compared with that of nonmesothelin expression group (p = .024). Univariate analysis showed that mesothelin expression is related to short-term survival. None of the 117 gastric adenocarcinomas stained for calretinin or WT1. CONCLUSIONS: Mesothelin expression was associated with poor prognosis. Our results suggest that mesothelin-targeted therapy should be considered as an important therapeutic alternative for gastric adenocarcinoma patients with mesothelin expression.

With increasing travel to tropical area, the number of patients with imported malaria in this country is increasing. RBC exchange transfusion has proposed as a adjunct therapy for very severe falciparum malaria to reduce the parasite load rapidly. We report a patient with severe Plasmodium falciparum infection with 26% of erythrocyte parasitized, treated with RBC exchange transfusion in addition to conventional chemotherapy. The exchange of 1200 mL of red blood cells was carried out with 7 packed red cells using automatic cell separator. This patients recovered from his disease despite respiratory distress syndrome and acute renal failure. We conclude that RBC exchange is a useful adjunct to conventional chemotherapy and should be considered in patients with severe and complicated falciparum malaria.
Acute Kidney Injury ; Drug Therapy ; Erythrocytes ; Humans ; Malaria ; Parasite Load ; Plasmodium falciparum* ; Plasmodium*

Purpose: This scoping review aims to provide established basic data on the characteristics and the effects of rehabilitation nursing interventions for improving the daily living ability and motor functions of stroke patients with hemiplegia to suggest the future direction of rehabilitation nursing interventions. Methods: The study population, concept and context were as of the following: ‘patients with hemiplegia’, ‘improvement of daily living abilities and motor functions’, and ‘published literature on the effects of rehabilitation nursing interventions’. Databases including PubMed, Embase, CINAHL, Cochrane Library, and DBpia were searched. Results: A total of 14 articles published within the past 5 years were identified. This review summarizes 1) the general characteristics of the reviewed literature (authors, year of publication, research method, research subjects), 2) the characteristics of the identified rehabilitation nursing interventions (interventionist, intervention type, period, measurement tool), 3) the effects of the rehabilitation nursing interventions, and the academic and clinical implications. Conclusion This scoping review provides theoretical basis for the future development of rehabilitation nursing interventions for stroke patients with hemiplegia.

No abstract available.
Malacoplakia* ; Umbilical Cord*

Atypical teratoid/rhabdoid tumor (AT/RT) of spine usually reported to develop in the brain, while it rarely manifest in the spine. It consists of rhabdoid cells and is highly malignant. AT/RT appears at various sites throughout the body, such as in the central nervous system, liver, kidneys, abdomen, and soft tissues. Among them, spinal AT/RT is rare, and AT/RT of lumbar spine is extremely rare; only a few cases have been reported. We present the case of an AT/RT of lumbar spine in a 16-month-old boy.