Apert syndrome is a rare genetic craniofacial disorder associated with premature fusion of multiple cranial sutures and syndactyly. It is caused by mutation in the fibroblast growth factor receptor 2 genes. The clinical findings are characterized by the typical dysmorphic facial features, including hypertelorism, proptosis and cleft palate. Most of these patients have widespread, severe acne involving the face, chest, back and forearms during puberty and the acne is unresponsive to conventional treatments. We report here on a patient with the recalcitrant acne of Apert syndrome and the patient had failed to respond to conventional acne treatment, but the acne was successfully treated with isotretinoin
Acne Vulgaris ; Acrocephalosyndactylia ; Cleft Palate ; Cranial Sutures ; Exophthalmos ; Forearm ; Humans ; Hypertelorism ; Isotretinoin ; Puberty ; Receptor, Fibroblast Growth Factor, Type 2 ; Syndactyly ; Thorax