1.Treatment of Ankylosing Spondylitis
Byeong-Jik KANG ; Sung-Sin JO ; Ye-Soo PARK
The Journal of the Korean Orthopaedic Association 2021;56(4):294-304
Ankylosing spondylitis causes ankylosis of the spine due to ossification of the articular cartilage and ligaments around the vertebral body as well as the sacroiliac joint. This pathophysiology limits joint movement and, in many cases, causes pain and deformity of the spine. If this disease is left untreated, it ultimately causes ankylosis and ossification of the whole-body joints. The symptoms generally develop before age 30 years, and the gradual progression of the disease adversely affects the physical function, professional ability, and quality of life. This increases the likelihood of developing psychiatric disorders, such as depression. The authors are aware of this severity and introduce recent trends and studies to prevent surgical treatment with various medications before systemic ossification. This paper presents various surgical treatments and complications in patients who were unable to prevent progression and underwent surgical treatment.
2.CT Findings of Endometrioma: Differential Points from Other Benign Complex Cystic Adnexal Masses.
In Ki BAEK ; Hong Soo KIM ; Doo Sung JEON ; Yang Sin PARK ; Hwang Jo KIM ; Hak Song RHEE
Journal of the Korean Radiological Society 1997;37(4):725-732
PURPOSE: To evaluate whether CT scanning is useful in differentiating the between endometriomas and other benign complex cystic adnexal masses, and in determining the method of treatment for each mass lesion. MATERIALS AND METHODS: In 54 cases (47 patients), we retrospectively analysed the CT findings of 20 pathologically-proven twenty endometriomas (bilateral in four cases), eight hemorrhagic functional cysts, two tubal ectopic pregnancies, eight tubo-ovarian abscesses (bilateral in two cases), ten serous cystadenomas (bilateral in one case), and six mucinous cystadenomas. Internal attenuation, the hyperdense portion, adhesion, and cul-de-sac obliteration were evaluated by CT scanning. RESULTS: Fourteen endometriomas (70%) showed a hyperdense portion, and in only two of these (10%), was a focal nodular hyperdense portion seen on pre-contrast CT scan (10% sensitivity, 100% specificity). Partial or complete cul-de-sac obliteration was identified in 11 patients (75%), while hemorrhagic functional cysts showed a hyperdense portion in four cases (50%) and were accompanied by partial cul-de-sac obliteration in two (25%). Two unruptured tubal ectopic pregnancies showed CT findings of unilateral hyperdense cystic masses of more than 60 HU. In all cases, tubo-ovarian abscesses were accompanied by thickening of the uterosacral ligament and deviation of thickened mesosalpinx (anterior deviation in 87.5% of patients). Serous and mucinous cystadenomas showed CT findings of hypodense masses (less than 20 HU) without adhesion or cul-de-sac obliteration, and this was helpful in differentiating cystadenomas from other benign cystic adnexal masses, including endometriomas. CONCLUSION: The evaluation by CT scanning of benign complex cystic adnexal masses with respect to the hyperdense portion and the presence or absence of cul-de-sac obliteration was usful in differentiating endometriomas from other lesions, and might be helpful in determining the method of treatment for each mass lesion.
Abscess
;
Cystadenoma
;
Cystadenoma, Mucinous
;
Cystadenoma, Serous
;
Endometriosis*
;
Female
;
Humans
;
Ligaments
;
Pregnancy
;
Pregnancy, Ectopic
;
Retrospective Studies
;
Tomography, X-Ray Computed
3.An aortic dissection in pregnant woman - a case report -.
Hyeong Min LEE ; Eun Pyo HONG ; Dong Hyup LEE ; Jung Cheul LEE ; Sung Sae HAN ; Dong Gu SIN ; Young Jo KIM ; Bong Sup SHIM
Yeungnam University Journal of Medicine 1993;10(1):253-259
We have experienced a case of aortic dissecting aneurysm in pregnant woman. She felt initially severe chest pain which was radiated to the neck on the 3days before delivery. Thereafter dyspnea and generalized edema were developed for 1 month after delivery. She was diagnosed as aortic dissectLn, Debakey type-II. During cardiopulmonary bypass, the selective cerebral perfusion was done through the right and left commom carotid arteries. Aortic replacement with Hemashield vascular graft and reimplantation of innominate artery, resuspension of aortic valve, repair of intimal tear were performed. The postoperative course was uneventful.
Aneurysm, Dissecting
;
Aortic Valve
;
Brachiocephalic Trunk
;
Cardiopulmonary Bypass
;
Carotid Arteries
;
Chest Pain
;
Dyspnea
;
Edema
;
Female
;
Humans
;
Neck
;
Perfusion
;
Pregnant Women*
;
Replantation
;
Tears
;
Transplants
4.Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
Ji Hyun SHIN ; Dong Jun BAE ; Eun Sung KIM ; Han Byeol KIM ; So Jung PARK ; Yoon Kyung JO ; Doo Sin JO ; Dong Gyu JO ; Sang Yeob KIM ; Dong Hyung CHO
Biomolecules & Therapeutics 2015;23(4):327-332
Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries and identified mefloquine, an anti-malaria medicine, as a potent regulator of primary cilia in human retinal pigmented epithelial (RPE) cells. Not only ciliated cells but also primary cilium length was increased in mefloquine-treated RPE cells. Treatment with mefloquine strongly induced the elongation of primary cilia by blocking disassembly of primary cilium. In addition, we found that autophagy was increased in mefloquine-treated cells by enhancing autophagic flux. Both chemical and genetic inhibition of autophagy suppressed ciliogenesis in mefloquine-treated RPE cells. Taken together, these results suggest that autophagy induced by mefloquine positively regulates the elongation of primary cilia in RPE cells.
Autophagy*
;
Cilia*
;
Humans
;
Mefloquine
;
Retinaldehyde
;
Small Molecule Libraries
5.A Case of Tricuspid Valve Endocarditis with Vegetation in a Non-Drug Addict without Underlying Cardiac Disease.
Eun Sook OH ; Sang Young RHO ; Bum Joon KIM ; Myoung A LEE ; Ki Dong YOO ; Ji Won PARK ; Chung Hyun CHOI ; Wook Sung CHUNG ; Wan Sik SIN ; Soon Jo HONG
Korean Circulation Journal 1998;28(8):1372-1377
Tricuspid valve endocarditis accounts for 5% to 10% of cases of infective endocarditis. It commonly occurs in intravenous drug abusers, intravenous catheters, alcoholism, immune deficiency and genital sepsis. But right sided infective endocarditis without predisposing factor is very rare. S. aureus is the usual pathogen. We experienced a case of tricuspid valve endocarditis in a 32 year old female with vegetation in a non drug addict without underlying cardiac disease. The vegetation on the septal cusp of tricuspid valve and tricuspid regurgitation were found by TTE & TEE. S. aureus was identified in 4 bottles of blood cultures. The diagnosis was delayed because the cardiac manifestations of the disease were subtle, and pleuropulmonary manifestations predominant. So we report a case of tricuspid valve endocarditis in a non drug addict without underlying cardiac disease with a review of literature.
Adult
;
Alcoholism
;
Catheters
;
Causality
;
Diagnosis
;
Drug Users
;
Endocarditis*
;
Female
;
Heart Diseases*
;
Humans
;
Sepsis
;
Tricuspid Valve Insufficiency
;
Tricuspid Valve*
6.A Case of Pulmonary Artery Aneurysm with Pulmonary Hypertension.
Jun Sik NAM ; Hong Geun JO ; Ik Mo JUNG ; Shi Hun PARK ; Sung Hun PARK ; Gil Ja SIN
Journal of the Korean Society of Echocardiography 1997;5(2):180-184
Clinical experiences of pulmonary artery aneurysm are distinctly rare and current knowledge is mainly derived from autopsy findings. Pulmonary artery aneurysms are associated with congenital heart disease, most frequently patient ductus arteriosus, followed in decreasing order by ventricular septal defect, atrial septal defect. In the remaining cases, such aneurysms are associated mainly with secondary acquired lesions, such as Behcet's disease, bacterial endocarditis, syphilis, tuberculosis, atherosclerosis, vasculitis, hypertension, trauma. Angiography was the gold standard for diagnosing pulmonary artery aneurysms, but MRI imaging has been potentially useful diagnostic modality in demonstrating aneurysm and other fine pathologic processes with high resolution. Surgery was main, but there are no firm guidelines for optimal treatment of pulmonary artery aneurysm. We experienced a case of pulmonary artery aneurysm with pulmonary hypertension in a 58 year-old female and observed for 2 years. The aneurysmal size was 5.19 cm initially and inreased to 5.5cm for two years, accompanying by pulmonary hypertension. We report this case of pulmonary artery aneurysm with a brief review of literature.
Aneurysm*
;
Angiography
;
Atherosclerosis
;
Autopsy
;
Ductus Arteriosus
;
Endocarditis, Bacterial
;
Female
;
Heart Defects, Congenital
;
Heart Septal Defects, Atrial
;
Heart Septal Defects, Ventricular
;
Humans
;
Hypertension
;
Hypertension, Pulmonary*
;
Magnetic Resonance Imaging
;
Middle Aged
;
Pathologic Processes
;
Pulmonary Artery*
;
Syphilis
;
Tuberculosis
;
Vasculitis
7.Clinical Evaluation of Risk Factors in Elderly patients with Reflux Esophagitis.
Chang Han PARK ; Sung Ae JUNG ; Yon Ju RYU ; Ji Yoon JO ; Young Sin KIM ; Hye Kyung JUNG ; Doe Young KIM ; Kwoon YOO ; Il Hwan MOON
Korean Journal of Gastrointestinal Motility 2002;8(2):139-145
BACKGROUND/AIMS: The elderly patients with reflux esophagitis are less likely to feel or report their symptoms than the younger patients, even though they are more prone to complications such as bleeding, stricture or Barrett's esophagus. In this study we tried to investigate risk factors in the elderly patients who had endoscopically diagnosed reflux esophagitis. METHODS: Clinical data of six hundred and eighty seven patients with reflux esophagitis were reviewed. RESULTS: Among the 687 patients with reflux esophagitis, two hundred and thirteen (31%) were 60 or more than 60 years old. The frequency of accompanying hiatal hernia in the elderly group (age>or=60) was significantly higher than the younger group (age<60) (16.9%, 36/213 vs. 3.4%, 16/474, p<0.05). There was significant difference according age in the female group (0.9%, 1/114 vs. 22.7%, 22/97, p<0.05). The frequency of atropic gastritis was significantly higher in the elderly group than in the younger group , while other factors such as smoking, H. pylori and peptic ulcer disease were not different between the two groups. CONCLUSION: Among the risk factors of reflux esophagitis, the existence of hiatal hernia seems to be suggested more relevant to the development of this condition in the elderly group.
Aged*
;
Barrett Esophagus
;
Constriction, Pathologic
;
Esophagitis, Peptic*
;
Female
;
Gastritis
;
Hemorrhage
;
Hernia, Hiatal
;
Humans
;
Middle Aged
;
Peptic Ulcer
;
Risk Factors*
;
Smoke
;
Smoking
8.Clinical Evaluation of Risk Factors in Elderly patients with Reflux Esophagitis.
Chang Han PARK ; Sung Ae JUNG ; Yon Ju RYU ; Ji Yoon JO ; Young Sin KIM ; Hye Kyung JUNG ; Doe Young KIM ; Kwoon YOO ; Il Hwan MOON
Korean Journal of Gastrointestinal Motility 2002;8(2):139-145
BACKGROUND/AIMS: The elderly patients with reflux esophagitis are less likely to feel or report their symptoms than the younger patients, even though they are more prone to complications such as bleeding, stricture or Barrett's esophagus. In this study we tried to investigate risk factors in the elderly patients who had endoscopically diagnosed reflux esophagitis. METHODS: Clinical data of six hundred and eighty seven patients with reflux esophagitis were reviewed. RESULTS: Among the 687 patients with reflux esophagitis, two hundred and thirteen (31%) were 60 or more than 60 years old. The frequency of accompanying hiatal hernia in the elderly group (age>or=60) was significantly higher than the younger group (age<60) (16.9%, 36/213 vs. 3.4%, 16/474, p<0.05). There was significant difference according age in the female group (0.9%, 1/114 vs. 22.7%, 22/97, p<0.05). The frequency of atropic gastritis was significantly higher in the elderly group than in the younger group , while other factors such as smoking, H. pylori and peptic ulcer disease were not different between the two groups. CONCLUSION: Among the risk factors of reflux esophagitis, the existence of hiatal hernia seems to be suggested more relevant to the development of this condition in the elderly group.
Aged*
;
Barrett Esophagus
;
Constriction, Pathologic
;
Esophagitis, Peptic*
;
Female
;
Gastritis
;
Hemorrhage
;
Hernia, Hiatal
;
Humans
;
Middle Aged
;
Peptic Ulcer
;
Risk Factors*
;
Smoke
;
Smoking
9.Endoscopically Exposed Coil after Embolization for Bleeding Duodenal Ulcer.
Young Chul JO ; In Du JEONG ; Kun Hyung CHO ; Su Jin SIN ; Hyun Soo KIM ; Hyo Sup LEE ; Jeong Woo SHIN ; Sung Jo BANG ; Neung Hwa PARK ; Jae Cheol HWANG ; Do Ha KIM
Korean Journal of Gastrointestinal Endoscopy 2005;30(1):39-42
Endoscopy has been the method of choice for the initial diagnosis and treatment of gastrointestinal bleeding. However, in the case of difficult localization or endoscopic failure, angiographic or surgical alternative may be recommended. The role of angiography has been emphasized recently to control upper GI bleeding. We experienced a case with deep ulcer displaying exposed vessel along the duodenal bulb, which imposed serious rebleeding risk. Although, active bleeding was controlled by the epinephrine injections in that patient, rebleeding risk was still high. So the patient underwent emergency angiography with embolization of the pancreaticoduodenal artery and gastroduodenal artery using multiple microcoils. Follow-up endoscopic examinations showed a coil protruding into the lumen from the ulcer bed, and the exposed coil at the ulcer base was completely by the regenerated epithelium three months later. Here in, we describe the rare case of a endodcopically exposed coil after embolization for bleeding duodenal ulcer which is the first case ever reported in Korea.
Angiography
;
Arteries
;
Diagnosis
;
Duodenal Ulcer*
;
Emergencies
;
Endoscopy
;
Epinephrine
;
Epithelium
;
Follow-Up Studies
;
Hemorrhage*
;
Humans
;
Korea
;
Ulcer
10.A case of kawasaki disease in an adult.
Yu Jin SUH ; Jae Woong CHO ; Jin Ho LEE ; Keu Sung LEE ; Sun Sin KIM ; Soo Keol LEE ; Ji Man HONG ; Jang Sung KIM ; Jo Won JUNG ; Dong Ho NAHM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 2001;21(1):96-102
Kawasaki disease (KD) is an acute vasculitis of undetermined etiology in infancy and early childhood. There is no diagnostic test to confirm this disease and its diagnosis is made on clinical backgrounds. Most patients diagnosed are under 4 years of age. Here, we report a case of KD in an adult presented with clinical features of fever, headache, and skin rash. A 26-year-old male was presented with fever and headache of four days' duration and skin rash of three days' duration. Nausea and vomiting developed and the patient was treated with antibiotics under the impression of aseptic meningitis and became afebrile two days later. Laboratory findings revealed thrombocytosis, atypical lymphocytes, and elevated liver enzymes. Kawasaki disease was diagnosed, and intravenous immunoglobulin and low-dose aspirin (200mg/d) was administered. Echocardiogram did not reveal any coronary artery changes and the skin lesions disappeared. The patient was discharged after near normalization of the liver enzymes and is now being followed at our clinic.
Adult*
;
Anti-Bacterial Agents
;
Aspirin
;
Coronary Vessels
;
Diagnosis
;
Diagnostic Tests, Routine
;
Exanthema
;
Fever
;
Headache
;
Humans
;
Immunoglobulins
;
Liver
;
Lymphocytes
;
Male
;
Meningitis
;
Meningitis, Aseptic
;
Mucocutaneous Lymph Node Syndrome*
;
Nausea
;
Skin
;
Thrombocytosis
;
Vasculitis
;
Vomiting