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1.Cough Variant Asthma.

Journal of the Korean Pediatric Society 1995;38(10):1340-1348

2.The effect of respiratory syncytial virus infection on neutrophil adherence to airway epithelial cells.

Hyun Hee KIM ; Joon Sung LEE ; Sung Hoon CHO

Journal of Asthma, Allergy and Clinical Immunology 1999;19(1):50-61

BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory infection in infants and young children, but the pathogenesis of RSV-induced inflammation is not well defined. MATERIAL AND METHOD: In order to examine the potential interactions between virus-infected airway epithelial cells and neutrophils, we studied the ability of neutrophils to adhere to yirus-infected airway epithelial cell monolayers by myeloperoxidase assay. Also we measured the ability of airway epithelial cells to secrete interleukin-8(IL-8) and inter-cellular adhesion molecule-1(ICAM-1) in virus-infected airway epithelial cell cultures by enzyme-linked immunosorbent assay(ELISA). The degree of IL-8 and ICAM-1 gene expression in the RSV-infected BEAS-2B cell cultures were analyzed by reverse transcription-polymerase chain reaction(RT-PCR). RESULTS: The RSV-infected BEAS-2B cell resulted in significantly enhanced level of neutrophil adherence compared to the uninfected control(p (0.001). IL-8 and ICAM-1 production significantly increased by RSV infection(p<0.05). There was a significant positive correlation between neutrophil adherence and IL-8 level(r=0.73, p=0.002), and ICAM-1 level (r=0.843, p=0.001) in RSV-infected cells. The degree of both IL-8 and ICAM-1 mRNA expression increased in the RSV-infected cells compared with the uninfected ones. CONCLUSION: These results suggest that RSV infection significantly enhances the production of IL-8 and ICAM-1 in airway epithelial cells which then results in increased neutrophil adherence.
Cell Culture Techniques ; Child ; Epithelial Cells* ; Gene Expression ; Humans ; Infant ; Inflammation ; Intercellular Adhesion Molecule-1 ; Interleukin-8 ; Neutrophils* ; Peroxidase ; Respiratory Syncytial Viruses* ; RNA, Messenger

3.The celluar composition including lymphocyte subsets in colostrum and mature milk from mothers of preterm and full term infancy.

Young Hoon KIM ; Joon Sung LEE ; Sung Hoon CHO

Pediatric Allergy and Respiratory Disease 1993;3(2):20-31

1.Cough Variant Asthma.

2.The effect of respiratory syncytial virus infection on neutrophil adherence to airway epithelial cells.

3.The celluar composition including lymphocyte subsets in colostrum and mature milk from mothers of preterm and full term infancy.

4.T lymphocyte responses to house dust mite in asthmatic children.

5.Immunologic Changes in Bronchial Asthma on Immunotherapy.

6.A histological study of surrounding bone tissue reaction to hydroxy apatite coated dental implant.

7.Clinical study of germ cell tumor of the ovary.

8.Clinical experiences of thumb reconstruction.

9.Normal anthropometric values and standardized templates of Korean face and head.

10.MR Imaging of a IVlature Teratoma in Third Ventricle: Case Report.

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