No abstract available.
Burns* ; Cerebral Hemorrhage*

Vasoconstrictive effect of several topicsl corticosteroids was measured using laser Doppler flowmeter. Hydrophilic ointment base, 1% hydrocortisone cream, 0.1% clocortolone pivalate cream, and 0.25% desoxymethasone cream were applied on both forearms of 20 volunteers. To augment the vasoconstrictive effect of the corticosteroids, We had cut off the blood flow to forearms for 4 minutes by tourniquet. The reactive hyperemia was measured by laser Doppler flowmeter and the ares under the curve were calculated by digitizer aided by a computer. The mean areas of esch drugs were in the following order : hydrophilic ointment base, 0.1% clocortolone pivalate cream, 1% hydrocortisone crearn and 0.25% desoxymethasone cream. However, the standard deviations were too large for the difference to be statistically significant. We concluded that laser Doppler flowmeter is not suitable for the measurement of vasoconstrictive effect of corticosteroid.
Adrenal Cortex Hormones ; Desoximetasone ; Flowmeters* ; Forearm ; Humans* ; Hydrocortisone ; Hyperemia ; Tourniquets ; Vasoconstriction ; Volunteers

Ae opposed to most other drug eruptions, drug-induced pemphigus may not develop for at least several months following the initiation of therapy with the offending agent. Unlike sporadically occuring pemphigus, the clinical and hietopathologic patterns of drug-induced pemphigus are most often those of pemphigus foliaceus. We report a case of diphenylhydantoin-induced pemphigus occuring in 30-year-old male with epilepsy. A few coinsized erythematous scaly patches developed on his fae, chest, snd left wrist, and two flaccid bullae on erythemstous base developed on his abdomen after three years snd nine months of therapy with diphenylhydantcin. Histopathologicslly, a biopsy specimin taken from a bullous lesion revealed that bulla is formed just beneath the granular layer and aeaitholytic cells are seen within the bulla. Direct and indirect irnmunofluorescence studies showed regitive findings. Administration of diphenylhydantoin was discontinued and he was treated with systemi and topical corticoeteroid. After 4 weeks, the skin lesions were healed with postinflammatory hysroigmentation and no new lesions were developed thereafter.
Abdomen ; Adult ; Biopsy ; Blister ; Drug Eruptions ; Epilepsy ; Humans ; Male ; Pemphigus* ; Phenytoin* ; Skin ; Thorax ; Wrist

We report a rare case of adreno-hepatic fusion in a 63-year-old man with a traumatic hepatic rupture. The adrenal tissue was located beneath the Glisson's capsule of the liver, and measured 3.5x2x0.3 cm. On histologic examination, the ectopic tissue was composed of both adrenal cortex and medulla surrounded by a delicate capsule of connective tissue.
Adrenal Cortex ; Choristoma ; Connective Tissue ; Humans ; Liver ; Middle Aged ; Rupture

Retrospective clinicopathologic analysis of 15 patients with the phyllodes tumors(PT) of the breast, diagnosed at SNUH over 6 years period, was done. By light microscopy, 8 cases were diagnosed as benign, and 7 cases were diagnosed as malignant. Mean ages o the patients were 37 and 34 years in malignant and benign, respectively. Most of those cases were presented with a palpable mass of the breast. None of the patients with malignant PT had distant metastasis, Local recurrences were experienced in 3 patients among the malignant PT, and one patient among the benign PT. One of 7 malignant PT was coexisted with simultaneous ipsilateral infiltrating duct carcinoma. The clinical course was not well correlated with pathologic features. The prognostic significances of several histopathologic parameters were assessed for possible correlation with local recurrence, metastasis and death; stromal cellularity, stromal cellular atypism, mitotic activity, tumor contour, necrosis, tumor size and heterologous stromal elements. Immunohistochemistry using antibody to vimentin, proliferating cell nuclear antigen(PCNA) and epidermal growth factor receptor(EGF-R) were analysed. In the 5 cases of benign PT, the stromal cells stained diffusely positive for vimentin and 3 cases of malignant tumors show similar staining for vimentin. The percentage of PCNA-positive cells were higher in the malignant PT than in the benign ones; they were 3.5% to 60% in malignancy, while they were less than 60% in all benign PT. The results of EGF-R staining were correlated with the histologic classification; only 2 cases out of 8 benign PT show diffusely positive staining of EGF-R in the cytoplasm, but 6 cases out of 7 malignant PT show positive findings.
Neoplasm Metastasis

The mucoepidermoid carcinoma is a rare tumor in the lung. A case of bronchial mucoepidermoid carcinoma diagnosed by fine needle aspiration cytology is presented. The smear showed many intermediate cells with occasional mucus-secreting cells. Malignant squamous cells were not present. The cellular arrangement of intermediate cells was overlapping and grouped in ball-like fashion. These cytologic features are unique for diagnosis of this tumor.
Biopsy, Fine-Needle ; Carcinoma, Mucoepidermoid ; Child* ; Diagnosis ; Glomerulonephritis* ; Humans ; Lung ; Mucoepidermoid Tumor

Developmental surface ultrastructure of Macroorchis spinulosus was studied by scanning electron microscopy. One-day-old juvenile fluke was leaf-shaped and bent ventrally. Body surface was covered densely with peg-like spines and with cobblestone-like cytoplasmic processes. Ciliated sensory papillae were concentrated around oral sucker. Several unciliated sensory papillae occurred equidistantly on oral sucker and acetabulum. The ciliated papillae appeared in two longitudinal lines symmetric bilaterally on dorsal surface. On adult flukes, tegumantal spines became wider in middle of the body surface. The cytoplasmic processes differentiated into more fine velvety form. It is likely that the differentiated fine cytoplasmic processes are an increased absorptive surface to adult M. spinulosus. It is suggested that single pointed tegumental spines on anterior half of the body may be supportive for this fluke to migration.
Animals ; Microscopy, Electron, Scanning ; Rats ; Rats, Sprague-Dawley ; Research Support, Non-U.S. Gov't ; Trematoda/*anatomy & histology/*ultrastructure

Statistical observation was made on 2,639 cases with heart disease which has been seen in the Deparment of Internal Medicine, National Medical Center, in Korea, during the past 15 years ranging from January 1959 to December 1973. The results were as follows; 1. During the last 15 years, 2,639 cases with heart disease were observed, which represents about 12.9% of total 20,434 medical In-patients, and variable incidence for the consecutive years was noted. 2. The disease occurred most frequently in group aged under thirty and its incidence decreased in the fifth and sixth decades. 3. The incidence in male was 49.8% and in female 50.2%, the ratio of which was almost same. 4. The most common etiologic form of heart disease was hypertensive heart disease which occurred in 43.2% of all cardiac patients, corresponding to 5.57% of all In-patients. The incidence was most frequent in the sixth decade and decreased in the fifth and fourth decades with the male preponderance. 5. The second common heart disease was rheumatic heart disease, 31.6% of all cardiac patients, corresponding to 4.08% of all In-patients. It affected the mitral valve in most of the cases, whereas involvement of the aortic valve was rare. 6. Coronary heart disease, the third common heart disease, occurred in 5.1% of all cardiac patients, and most frequently in sixth and seventh decades. it affected male 2.5 times more frequently than female. 7. Postpartum heart failure and beriberi heart disease showed 3.8% and 3.1% respectively. They occurred more frequently in younger female, but the frequency was much decreased recently. 8. Pericarditis occured in 2.6% of all cardiac patients and tuberculosis was still a common cause of pericarditis. 9. Congenital heart disease was seen in 1.7% of the cases and patent ductus arteriosus, tetralogy of Fallot, atrial septal defect and ventricular septal defect occupied 76% of all congenital heart disease. 10. Cor pulmonale was present in 1.6%, arrhythmia 1.3%, cardiomyopathy 1.3%, thyroid heart disease 0.8%, endocarditis 0.7% and syphilitic heart disease 0.2%.
Aortic Valve ; Arrhythmias, Cardiac ; Beriberi ; Cardiomyopathies ; Coronary Disease ; Ductus Arteriosus, Patent ; Endocarditis ; Female ; Heart Defects, Congenital ; Heart Diseases* ; Heart Failure ; Heart Septal Defects, Atrial ; Heart Septal Defects, Ventricular ; Heart* ; Humans ; Incidence ; Internal Medicine ; Korea* ; Male ; Mitral Valve ; Pericarditis ; Postpartum Period ; Pulmonary Heart Disease ; Rheumatic Heart Disease ; Tetralogy of Fallot ; Thyroid Gland ; Tuberculosis

The authors developed a computer program for use in report printing as well as data storage and retrieval for the gastrointestinal endoscopy service. This program used IBM PC XT and was written in dBASE III plus language. We applied the automatic SNOMED coding method, which is one of the most efficient and accurate method of computerization of medical data. The working sheet which contained the results of previous endoscopic studies could be printed during registration. The dBASE word processor enabled issuing of the formal report of endoscopic result, and the data storage was carried out during the typewriting of the report. Two kinds of data files were stored in the hard disk; the temporary file contained full informations and the permanent file contained patients identification data and SNOMED code. Searching of a specific case was performed by chart number, patients name, date of study, or SNOMED code within a second. All the cases were arranged by SNOMED codes of procedure, topography and morphology codes. Every new data was copied to the diskette automatically. with which data could be restored in case of hard disk failure. The main advantages of this program in comparison to the large main frame computer system are low price, flexibility and easy accessibility. Based on our experience (including surgical pathology department, radiology, clinical pathology), we assume that this program may fit every endoscopy room where there are less than 20,000 cases per year.
Information Storage and Retrieval ; Clinical Coding* ; Computer Systems ; Endoscopy ; Endoscopy, Gastrointestinal* ; Humans ; Information Storage and Retrieval* ; Pathology, Surgical ; Pliability ; Systematized Nomenclature of Medicine

Serum levels of HDL-cholesterol, triglyceride and total cholesterol were measured in 107 normal Koreans and in 327 patients; 66 patients with hypertension, 34 patients with coronary heart disease, 45 patients with cerebral thrombosis, 18 patients with nephrotic syndrome, and 164 patients with diabetes mellitus. Patterns of serum lipoprotein fractions were also investigated by agarose gel electrophoresis in 41 normal Koreans and in 72 patients; 14 patients with hypertension, 10 patients with coronary heart disease, 19 patients with cerebral thrombosis, 7 patients with nephrotic syndrome, and 22 patients with diaebetes mellitus. The results are summarized as follows; 1. Mean values of serum HDL-cholesterol, triglyceride and cholesterol in normal Koreans were 52.2+/-12.4mg/100ml, 110.6+/-31.6mg/100ml and 175.3+/-21.4mg/100ml respectively. No significant difference in mean value of serum HDL-cholesterol was observed between Korean males and females. 2. In Korean females serum, HDL-cholesterol level showed peak values in the fifth decade, but no significant difference with aging was observed in Korean males. 3. Serum HDL-cholesterol levels were significantly decreased in patients with hypertension, coronary heart disease, cerebral thrombosis, and in male diabetic patients with complication. 4. Serum triglyceride levels were significantly increased in all the disease groups, and serum cholesterol levels were significantly increased in all the disease groups except cerebral thrombosis. 5. Mean values of alpha-lipoprotein, pre-beta-lipoprotein and beta-lipoprotein fraction ratios in normal Koreans were 28.9+/-7.5%, 14.9+/-4.9% and 56.2+/-8.1% respectively. 6. Seum alpha-lipoprotein fraction ratio was significantly decreased in relatively advanced hypertensive patients. Pre-beta-lipoprotein fraction ratio tends to be increased in patients with hypertension, cerebral thrombosis, nephrotic syndrome and in diabetic patients with complications, and beta-lipoprotein fraction ratio tends to be increased in patients with hypertension, coronary heart disease and nephrotic syndrome, but those were not statistically significant.
Aging ; Cardiovascular Diseases* ; Cholesterol ; Coronary Disease ; Diabetes Mellitus ; Electrophoresis, Agar Gel ; Female ; Humans ; Hypertension ; Intracranial Thrombosis ; Lipoproteins ; Male ; Nephrotic Syndrome ; Triglycerides