No abstract available.
Child* ; Humans ; Hypertension*

Proliferations of the endometrial glands form a continuum from focal glandular crowding through simple hyperplasia, complex hyperplasia and atypical hyperplasia to frank adenocarcinoma. But objective criteria to distinguish these proliferative endometrial lesions are not clear-cut and terminology is confusing. The p53 protein is a nuclear phosphoprotein that can regulate cell proliferation and suppress tumor growth. Mutation in the p53 gene have been reported in a variety of human tumors, and in selected malignancies overexpression of p53 has been associated with poor prognosis. In this study we examined a series of endometrial proliferative lesion, including hyperplasia, adenocarcinoma, and adenomyosis to determine whether or not p53 is overexpressed in these lesions. In the result, p53 immunoreactivity was observed in 3 of 17 (17.6%) simple hyperplasia, one of 6 (16.6%) complex hyperplasia, none of 3 (O%) atypical hyperplasia, 6 of 13 (46.1%) adenocarcinoma and none of 10 (O%) adenomyosis. In conclusion, p53 mutation seems to play a role in oncogenesis of endometrial adenocarcinoma in early phase but there was no significant relationship between p53 overexpression and histologic grade of adenocarcinoma.
Adenocarcinoma* ; Adenomyosis ; Carcinogenesis ; Cell Proliferation ; Crowding ; Endometrial Hyperplasia* ; Female ; Genes, p53 ; Humans ; Hyperplasia ; Prognosis

20 cases of midline pineal tumors and 3 suprasellar germinomas received radiation therapy at Yonsei University Medical College, Severance hospital from 1971 to 1982 were reviewed. 12 cases were pathologically proved; 10 germinomas, 1 pineoblastoma, and 1 pineocytoma. 11 cases received radiotherapy without biopsy confirmation. Although treatment fields varied from small field to whole brain irradiation, but not to the spinal cord, most patients received 4000-000 rads irradiation to the primary tumor site. 17 patients are alive without evidence of disease and 5 year actuarial NED survival is 73.2%. 9 of 10 biopsy proved germinomas and all 6 presumed germinomas are alive and well. Optimum radiation dose, adequate irradiation field, tumor response to radiation observed in serial CT scan and role of radiation therapy in the management of pineal tumors are also discussed.
Biopsy ; Brain ; Germinoma* ; Humans ; Pinealoma* ; Radiotherapy ; Spinal Cord ; Tomography, X-Ray Computed

PURPOSE: This study aimed to investigate early and mid-term outcomes of carotid artery stenting (CAS). METHODS: We retrospectively reviewed 111 patients who were treated for carotid stenosis between October 2004 and December 2009 (42 CASs and 69 carotid endarterectomies [CEAs]). RESULTS: CAS group was older than CEA group (70 years vs. 67 years, P = 0.001). Coronary artery disease and high lesion above the 2nd cervical vertebral body were more common in CAS group (29% vs. 13%, P = 0.002; 4% vs. 24%, P = 0.004). The 30-days stroke rate was higher in CAS group (10% vs. 1% in CEA group, P = 0.067, Fisher's exact test). New brain lesions on diffusion-weighted magnetic resonance imaging were more common in CAS group (48% vs. 20% in CEA group, P = 0.002, chi-square test). The 1-, 3-year freedom from stroke were 91%, 84% in CAS group and 99%, 99% in CEA group (P = 0.007, log-rank test). Univariate analysis showed that female gender and age > 70 years were related with postprocedural neurological complications (P = 0.046 and P = 0.007, log-rank test). However, none were independent risk factors on multivariate analysis. CONCLUSION: In our series, the rates of peri-procedural neurological complications in CAS group were significantly high. These results suggest that more experience and restricted patient selection will be needed for CAS.
Brain ; Carotid Arteries ; Carotid Stenosis ; Coronary Artery Disease ; Endarterectomy ; Endarterectomy, Carotid ; Female ; Freedom ; Humans ; Magnetic Resonance Imaging ; Patient Selection ; Penicillanic Acid ; Retrospective Studies ; Risk Factors ; Stents ; Stroke

PURPOSE: To evaluate factors that predict prognosis of colon perforation, we review the hospital records of 37 patients who underwent emergency operation for colon perforation. METHODS: Information of clinical findings, Acute Physiology and Chronic Health Evaluation (APACHE II score), perforation sites and causes, operation methods, and postoperative complications were obtained. RESULTS: The causes of perforation were traumatic 11 (29.7%), iatrogenic 10 (27.0%), diverticular 6 (16.2%), cancerous process 6 (16.2%), strangulated hernia 2 (5.4%), ischemic colitis 1 (2.7%) and stercoral 1 (2.7%). The longer duration from colon perforation to operation, the more severe intra-abdominal fecal contamination was seen. The complication rate was increased as the intra-abdominal fecal contamination increased or APACHE II score increased (p<0.05). But there were no correlation between the complication rate and perforation sites and causes. In according to operative managements, one-stage operation (simple closure or resection with anastomosis) group had more lower complication rate than two-stage operation (formation of colostomy) group, unexpectedly (31.3% vs. 52.4%, p>0.05). Also former group had lower complication rate compared to latter group in left colon (40% vs 50%). CONCLUSIONS: The factors that predict of mortality and morbidity are not perforation site, causes, and operation method, but preoperative physiologic status (APACHE II score) and intra-abdominal fecal contamination. So preoperative proper and vigorous treatment for improvement of physiologic status and shortening of interval to operation are important for better results. And primary closure and resection with anastomosis is useful for colon perforation in selected circumstance regardless of its site and cause.
APACHE ; Colitis, Ischemic ; Colon* ; Colostomy ; Emergencies ; Hernia ; Hospital Records ; Humans ; Mortality ; Postoperative Complications ; Prognosis

Paragonimiasis caused by Paragonimus westermani is essentially a pulmonary disorder, but it is also known to cause ectopic parasitism at various sites in human host such as the brain, muscle, liver, spinal cord and spleen. Ectopic parasitism of the female genital tract, especially the ovary is relatively rare. We have experienced a case of a 62-year-old Korean woman with asymptomatic ectopic paragonimiasis in the salpinx , ovary, and cul de sac.
Female ; Humans

BACKGROUND: During the adolescent growths spurt, iron deficiency becomes more common, particularly with the additional factors of menstrual blood loss in females and the androgen-related rise in hemoglobin concentration in males. This study was conducted to investigate the iron status in the adolescent students. METHODS: Venous peripheral blood was sampled from 178 males(79 of 12-13years, 99 of 15-16years) who were 1st grade students of two boy's middle schools and two high schools and from 186 females(87 of 12-13years, 99 of 15-16years) who were 1st grade students of two girl's middle schools and two high schools. Laboratory procedures included a hemoglobin, hematocrit, serum iron, TIBC and serum ferritin. Transferrln saturation was calculated. RESULTS: 1) Mean values were hemoglobin 13.7+/-0.78 g/dl, hematocrit 40.6+/-2.47%, serum iron 127.6+/-43.02 ug/dl, TIBC 387.9+/-47.73 ug/dl, transferrin saturation 33.3+/-11.38%, and serum ferritin 26.1+/-16.90 ng/ml in 12-13years old males. 2) Mean values were hemoglobin 13.7+/-0.85 g/dl, hematocrit 40.9+/-3.79%, serum iron 99.4+/-34.93 ug/dl, TIBC 387.8+/-45.53 ug/dl, transferrin saturation 26.2+/-9.99%, and serum ferritin in 22.7+/-14.18 ng/ml in 12-13years old females. 3) Mean values were hemoglobin 15.2+/-0.84 g/dl, hematocrit 45.9+/-2.77%, serum iron 144.9+/-51.97 ug/dl, TIBC 419.8+/-52.46 ug/dl, transferrin saturation 34.2+/-10.44%, and serum ferritin 31.2+/-20.91 ng/dl in 15-16years old males. 4) Mean values were hemoglobin 13.2+/-0.89 g/dl, hematocrit 39.9+/-2.78%, serum iron 111.1+/-39.78 ug/dl, TIBC 392.8+/-50.06 ug/dl, transferrin saturation 28.9+/-10.85%, and serum ferritin 21.4+/-17.11 ng/ml in 15-16years old females. 5) The prevalence of iron deficiency was 8.9% and 10.1% in 12-13years and 15-16years old males respectively. In 12-13years and 15-16years old females, the prevalence was 16.1% and 29.3% respectively. The prevalence of iron deficincy anemia was 1.1% and 2.0% in 12-13years and 15-16years old female and absent in male. CONCLUSIONS: Although hemoglobin is normal, we recommend to check other parameters to optimize the identification of individuals with iron deficiency.
Adolescent* ; Anemia ; Female ; Ferritins ; Hematocrit ; Humans ; Iron* ; Male ; Prevalence ; Seoul* ; Transferrin

Vacuum disc phenomenon is a collection of gas in the intervertebral disc space but rarely causes nerve compression. However, some rare type of vacuum phenomenon in the spinal canal may bring about posterior gas displacement within the epidural space. The authors describe two patients with symptomatic epidural gas-containing cyst that seem to be originating from vacuum phenomenon in the intervertebral disc, causing lumbosacral radiculopathy. Radiographic studies demonstrated intervertebral vacuum phenomenon and accumulation of gas in the lumbar epidural space compressing the dural sac and the nerve root. The nerve root in both patients was compressed by gas containing cyst that was surrounded by thin walled capsule separable from the gaseous degenerated disc space. The speculative mechanism of the nerve root compression is discussed. The possibility of gas containing cyst should be considered in case of the nerve root compression in which epidural gas is present.
Displacement (Psychology) ; Epidural Space ; Humans ; Intervertebral Disc ; Radiculopathy ; Spinal Canal ; Vacuum

No abstract available.
Prostate*

A lumbar juxtafacet cyst is a rare disease that causes low back pain, radiculopathy and neurological claudication by compressing the nerve roots. A 34-year-old male complained of severe low back pain and radicular pain in the right lower extremity. Magnetic resonance images revealed a cyst at the lateral recess of the spinal canal between the L3-4 disc and posterior facet joint that extended to the L4 body level. Under the guidance of an image intensifier, needle aspiration of the cyst was performed, which extracted 1.5 ml of serous, yellowish colored fluid. After the aspiration, the symptoms subsided dramatically. The follow-up magnetic resonance images showed no recurrence of the cyst. To the best of the author’s knowledge, there are no reports of lumbar juxtafacet cyst treated with needle aspiration in Korea. This case is reported with a review of the relevant literature.