1.Toremifene-associated endometrial polyp: A case report and review of the literature.
Eun Hee PARK ; Sung Yun BAHNG ; Tae Sung KIM ; Seong Taek MUN ; Jib Kwang CHUNG ; Seok Min LEE ; So Young JIN
Korean Journal of Obstetrics and Gynecology 2002;45(7):1214-1217
Antiestrogens have been widely used in the treatment of breast cancer patients. Although tamoxifen is one of the most prevalent antiestrogens, some reported its hepatocarcinogenic effects and the long-term treatment may increase the risk of endometrial and gastrointestinal cancer. Toremifene is an interesting new antiestrogen and have a similar antitumor efficacy as tamoxifen, with less side-effect including less uterotrophic effect compared to tamoxifen, in mice. we report a case of endometrial polyp which were associated with toremifene use, in postmenopausal woman with breast cancer, with a brief review of literature.
Animals
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Breast Neoplasms
;
Estrogen Receptor Modulators
;
Female
;
Gastrointestinal Neoplasms
;
Humans
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Mice
;
Polyps*
;
Tamoxifen
;
Toremifene
2.The Clinical Significance of Uterine Artery Doppler Flow Velocity Waveforms as a Screening Test in the Second Trimester Pregnancies.
Seon Yeong PARK ; Kyu Yeon CHOI ; Mi Kyoung KANG ; Sung Yun BAHNG ; Eun Hee PARK ; Mi Kyoung KIM ; Jeong Jae LEE ; Im Soon LEE
Korean Journal of Perinatology 2005;16(3):244-249
OBJECTIVE: We performed uterine artery doppler flow velocity waveforms between 20~24 weeks of gestation to access the screening properties for predicting pregnancy-induced hypertension or intrauterine growth retardation in general population. METHODS: Total 458 normal pregnant women were enrolled in this study. The abnormal uterine artery doppler flow velocity waveforms was defined that systolic/diastolic ratio is greater than 2.6 or diastolic notch waveforms are seen. RESULTS: The incidence of PIH and IUGR among study population was 3.5% and 3.5%, respectively. The incidence of PIH in normal and abnormal uterine artery Doppler flow velocity waveforms group were 2.0% and 11.4%, and those of IUGR were 3.4% and 4.2%, respectively. The incidence PIH or IUGR among abnormal doppler group was 14.2%, which was higher than in normal group of 5.4%. This method had a sensitivity of 34.3%, a specificity of 86.1% and positive predictive value of 15.7% for the prediction of PIH and IUGR. CONCLUSION: Although abnormal uterine artery doppler flow velocity waveforms is associated with an increased risk of PIH or IUGR, the lowered positive predictability lead to apply the follow-up examination or standardization of doppler ultrasonography.
Female
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Fetal Growth Retardation
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Follow-Up Studies
;
Humans
;
Hypertension, Pregnancy-Induced
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Incidence
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Mass Screening*
;
Pregnancy
;
Pregnancy Trimester, Second*
;
Pregnant Women
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Sensitivity and Specificity
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Ultrasonography, Doppler
;
Uterine Artery*