No abstract available.

No abstract available.
Telephone*

No abstract available.
Endometriosis* ; Exons* ; Female ; Humans ; Polycystic Ovary Syndrome*

No abstract available.
Heart Neoplasms*

Pigmented Bowen's disease is characterized by microscopically increased melanin pigment in the epidermis and/or papillary dermis in addition to the typical findings of Bowen's disease. This disorder is infrequently reported and represents less than 2% of cases of Bowen's disease. Pigmented Bowen's disease is often confused clinically with pigmented lesions, such as seborrheic keratosis, melanocytic nevus, pigmented basal cell cacinoma and superficial spreading melanoma. A 74-year-old man presented with a black hyperkeratotic nodule overlying a solitary dark brownish patch on the scalp, this was clinically diagnosed as seborrheic keratosis. Histopathologic examination revealed pigmented Bowen's disease. We, herein, report an unusual case of pigmented Bowen's disease, which is the first reported case to have occurred on the scalp and to clinically resemble seborrheic keratosis.
Aged ; Bowen's Disease* ; Dermis ; Epidermis ; Humans ; Keratosis, Seborrheic* ; Melanins ; Melanoma ; Nevus, Pigmented ; Scalp

BACKGROUND: Resistance of Mycobacterium tuberculosis to anti-tuberculosis (TB) drugs is almost exclusively due to spontaneous chromosomal mutations in target genes. Rapid detection of drug resistance to both first- and second-line anti-TB drugs has become a key component of TB control programs. Technologies that allow rapid, cost-effective, and high-throughput detection of specific nucleic acid sequences are needed. This study was to develop a high-throughput assay based on allele-specific primer extension (ASPE) and MagPlex-TAG microspheres to detect anti-TB drug resistance mutations. METHODS: DNA samples from 357 M. tuberculosis clinical isolates and H37Rv were amplified by multiplex PCR using four primer sets, followed by multiplex ASPE using 23 TAG-ASPE primers. The products were sorted on the TAG-ASPE array and detected by using the Luminex xMAP system. Genotypes were also determined by sequencing. RESULTS: Genetic drug susceptibility typing by the TAG-ASPE method was 100% concordant with those obtained by sequencing. Compared with phenotypic drug susceptibility testing (DST) as a reference method, the sensitivity and specificity of the TAG-ASPE method were 83% (95% confidence interval [CI], 79-88%) and 97% (95% CI, 90-100%) for isoniazid. For rifampin testing, the sensitivity and specificity were 90% (95% CI, 86-93%) and 100% (95% CI, 99-100%). Also, the sensitivity and specificity were 58% (95% CI, 51-65%) and 86% (95% CI, 79-93%) for ethambutol. CONCLUSIONS: This study demonstrated the TAG-ASPE method is suitable for highly reproducible, cost-effective, and high-throughput clinical genotyping applications.
DNA ; Drug Resistance* ; Ethambutol ; Genotype ; Isoniazid ; Microspheres ; Multiplex Polymerase Chain Reaction ; Mycobacterium tuberculosis ; Rifampin ; Tuberculosis ; Viperidae

OBJECTIVE: The purpose of this study was to investigate the characteristics of orthodontic patients at Yonsei Dental Hospital from 2008 to 2012. METHODS: We evaluated Angle's classification from molar relationships, classification of skeletal malocclusion from the A point-nasion-B point angle, facial asymmetry, and temporomandibular joint disorders (TMDs) from the records of 7,476 patients who received an orthodontic diagnosis. The orthognathic surgery rate, extraction rate, and extraction sites were determined from the records of 4,861 treated patients. RESULTS: The patient number increased until 2010 and gradually decreased thereafter. Most patients were aged 19-39 years, with a gradual increase in patients aged ≥ 40 years. Angle's Class I, Class II divisions 1 and 2, and Class III malocclusions were observed in 27.7%, 25.6%, 10.6%, and 36.1% patients, respectively, with a gradual decrease in the frequency of Class I malocclusion. The proportion of patients with skeletal Class I, Class II, and Class III malocclusions was 34.3%, 34.3%, and 31.4%, respectively, while the prevalence of facial asymmetry and TMDs was 11.0% and 24.9%, respectively. The orthognathic surgery rate was 18.5%, with 70% surgical patients exhibiting skeletal Class III malocclusion. The overall extraction rate among nonsurgical patients was 35.4%, and the maxillary and mandibular first premolars were the most commonly extracted teeth. CONCLUSIONS: The most noticeable changes over time included a decrease in the patient number after 2010, an increase in the average patient age, and a decrease in the frequency of Angle's Class I malocclusion. Our results suggest that periodic characterization is necessary to meet the changing demands of orthodontic patients.
Bicuspid ; Classification ; Diagnosis ; Epidemiology ; Facial Asymmetry ; Humans ; Korea* ; Malocclusion ; Molar ; Orthognathic Surgery ; Prevalence ; Temporomandibular Joint Disorders ; Tooth

Seborrheic keratosis is a benign epidermal neoplasm, but malignant transformation may, rarely occur. We, herein, report an unusual case of Bowen's disease arising in seborrheic keratosis. A 74-year-old man presented with multiple grouped erythematous to dark brownish papules on the left shoulder for 9 months. Histopathologic examination taken from the largest papule of the left shoulder revealed the findings of seborrheic keratosis connecting with Bowen's disease. This case supports the possibility of malignant transformation of seborrheic keratosis.
Aged ; Bowen's Disease* ; Humans ; Keratosis, Seborrheic* ; Shoulder

A 21-year-old man presented with a solitary 14x10cm sized slightly elevated firm plaque with partial hair loss on the right parietal scalp, which he had had since birth. Histopathologic examination revealed typical findings of congenital intradermal nevus. As a preoperative procedure a 300cc capacity crescentic expander was placed under the uninvolved scalp. Inflation and expansion of uninvolved left parietal scalp with saline over a 10-week period allowed excision of a 14x10 cm sized area of medium-sized congenital intradermal nevus. No hematoma or infection of the expanded skin occurred. We, herein, report an unusual case of diffuse congenital, nonpigmented, intradermal nevus with partial alopecia on the scalp, which was successfully treated with complete excision used by tissue expander.
Alopecia ; Hair ; Hematoma ; Humans ; Inflation, Economic ; Nevus, Intradermal* ; Parturition ; Preoperative Care ; Rabeprazole ; Scalp* ; Skin ; Tissue Expansion Devices* ; Young Adult

OBJECTIVE: To gain basic information regarding the biologic stability of plasma ion-implanted miniscrews and their potential clinical applications. METHODS: Sixteen plasma ion-implanted and 16 sandblasted and acid-etched (SLA) miniscrews were bilaterally inserted in the mandibles of 4 beagles (2 miniscrews of each type per quadrant). Then, 250 - 300 gm of force from Ni-Ti coil springs was applied for 2 different periods: 12 weeks on one side and 3 weeks contralaterally. Thereafter, the animals were sacrificed and mandibular specimens including the miniscrews were collected. The insertion torque and mobility were compared between the groups. The bone-implant contact and bone volume ratio were calculated within 800 microm of the miniscrews and compared between the loading periods. The number of osteoblasts was also quantified. The measurements were expressed as percentages and analyzed by independent t-tests (p < 0.05). RESULTS: No significant differences in any of the analyzed parameters were noted between the groups. CONCLUSIONS: The preliminary findings indicate that plasma ion-implanted miniscrews have similar biologic characteristics to SLA miniscrews in terms of insertion torque, mobility, bone-implant contact rate, and bone volume rate.
Animals ; Mandible ; Nickel ; Osteoblasts ; Plasma ; Population Characteristics ; Titanium ; Torque