No abstract available.
Liver*

No Abstract Available.
Female ; Hormone Replacement Therapy* ; Humans ; Life Style* ; Osteoporosis*

Congenital hypertrophic pyloric stenosis is the most common intra-abdominal disease required surgery during the first few months of life. The expression of pyloric stenosis is dependent upon the genetic influence of ancestors affected with the disease, as well as unknown environmental influences in the postnatal period. Pyloric stenosis has been reported in multiple sibs in a family, which suggests the genetic influence on the expression of this disease. Until now, the genetic influence is thought a sex-modified polygenic or multifactorial background which facilitates the expression of a common dominant gene. We experienced a case of congenital hypertrophic pyloric stenosis in a two siblings. The siblings suffered projectile vomiting for 2~4 days at 16 days old of age and 15 days old of age. After we confirmed the diagnosis by upper gastrointestinal series and abdominal sonogram, the Fredet-Ramstedt pyloromyotomy was done successfully. This case suggests the genetic influence on the expression of this disease.
Diagnosis ; Genes, Dominant ; Humans ; Pyloric Stenosis ; Pyloric Stenosis, Hypertrophic* ; Siblings* ; Vomiting

Although we managed a patient with traumatic endophthalmitis with potent antibiotics for 7 days topically and systemically, her clinical symtoms and signs did not improved and her visual activity decreased from hand motion to light perception. So, we performed pars plana vitrectomy and lensectomy using the Ocutome(R) and Frognatome(TM) and achieved a successful result with final visual acuity of 50 cm finger count or better without evidence of phthisis bulbi in this case.
Anti-Bacterial Agents ; Endophthalmitis* ; Fingers ; Hand ; Humans ; Visual Acuity ; Vitrectomy*

Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.
Animals ; Central Nervous System Sensitization ; Discrimination (Psychology) ; Neuralgia ; Neurons ; Posterior Horn Cells ; Rats ; Spinal Cord ; Spinal Cord Injuries

Staphylococci are known to produce catalase, but there have been a few case reports of catalase-negative Staphylococcus aureus. The present report describes the first case of catalase-negative S. aureus associated with vaselinoma to our knowledge. We isolated a catalase-negative strain of S. aureus from a penile wound of a 35-year-old man who injected with vaseline into his penis 9 months ago. Colony morphology and biochemical reactions of the strain were typical of S. aureus except for catalase. The patient was diagnosed as having vaselinoma with wound infection and was successfully treated by the surgical removal of the vaseline granuloma and the administration of appropriate antibiotics. Catalase-negative S. aureus is considered to be a very rare variant of S. aureus. To date the number of reported cases of catalase-negative S. aureus is very few, so further studies need to be conducted to evaluate its clinical relation.
Adult ; Anti-Bacterial Agents ; Catalase ; Granuloma ; Humans ; Male ; Penis ; Petrolatum ; Staphylococcus aureus* ; Staphylococcus* ; Wound Infection* ; Wounds and Injuries*

STUDY DESIGN: A case report. OBJECTIVES: To report a case of diagnostic, clinical and radiologic follow-up of a non-traumatic atlanto-axial rotatory subluxation. SUMMARY OF LITERATURE REVIEW: Atlanto-axial rotatory subluxation, caused by a non-traumatic inflammation or infectious diseases, has been branded as "Grisel's syndrome". However, the pathophysiology of the syndrome has not been clearly understood, and its diagnostic criteria and appropriate treatment plans are not established. MATERIALS AND METHODS: The patient suffering from antlanto-axial subluxation without any neurological symptoms was treated with halter traction and Miami J brace. RESULTS: The patient maintained a normal reduction state, and a normal cervical movement was observed after undergoing 4 weeks of non-surgical treatment. CONCLUSION: Early detection and treatment are essential and critical in avoiding catastrophic outcomes. It requires a combination of clinical assessment and appropriate radiographic imaging.
Communicable Diseases ; Follow-Up Studies ; Humans ; Inflammation ; Stress, Psychological ; Traction

OBJECTIVE: This study was performed to evaluate the expression of MAGE gene and human papillomavirus (HPV) 16, 18 type in patients with cervical neoplasia using in exfoliated cervical cells. METHODS: The expression of common MAGE gene (MAGE 1 to 6) in cervical scraps was studied by reverse-transcription polymerase chain reaction (RT-PCR) in 12 normal control patient and 48 patients with abnormal cytologic results. In all 60 patients, colposcopic directed biopsy and HPV test by polymerase chain reaction (PCR) was done. RESULTS: The pathologic results of 60 patients was 12 cervicitis, 37 cervical intraepithelial neoplasia (14 LSIL, 23 HSIL), and 11 invasive squamous cell carcinomas. No expression of common MAGE gene was detected in 12 cervical scraps of cervicitis. The common MAGE gene of LSIL, HSIL and invasive squamous cell carcinomas was expressed in two (14.3%), seventeen (73.9%), ten (90.9%) respectively. HPV type 16 or 18 was detected in 1 cervicitis, 5 LSIL, 20 HSIL and 10 invasive squamous cell carcinoma. In 51 patients (85%), the HPV test result and the common MAGE gene expression showed coincident results. CONCLUSION: This result suggests common MAGE gene might be potential tumor marker in cervical neoplasia and adjuvant test of the Papanicolaou smear.
Biopsy ; Carcinoma, Squamous Cell ; Cervical Intraepithelial Neoplasia ; Gene Expression ; Human papillomavirus 16* ; Humans* ; Papanicolaou Test ; Polymerase Chain Reaction ; Uterine Cervicitis

No abstract available.
Apoptosis* ; Placenta Previa* ; Placenta*

OBJECTIVES: Delphinidin is one of the anthocyanidins. It is believed to have anti-inflammatory property including antioxidant, antiangiogenic, and anti-cancer properties. However, the anti-inflammatory effect of delphinidin in mucin-producing human airway epithelial cells has not been determined. Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of delphinidin in lipopolysaccharide (LPS)-induced MUC8 and MUC5B expression in human airway epithelial cells. METHODS: In mucin-producing human NCI-H292 airway epithelial cells and primary cultures of normal nasal epithelial cells, the reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, enzyme immunoassay were used for investigating the expressions of MUC8, MUC5, and Toll-like receptor 4 (TLR4), after LPS treatment and delphinidin treatment. And the signaling pathway of delphinidin on LPS-induced MUC8 and MUC5B expression was investigated using the RT-PCR, and immunoblot analysis. To confirm the involvement of TLR4 in LPS-induced MUC8 and MU5B expression, the cells were transfected with TLR4 siRNA. RESULTS: In NCI-H292 airway epithelial cells, LPS (100 ng/mL) significantly induced TLR4, MUC8, and MUC5B expression. TLR4 siRNA significantly blocked LPS-induced MUC8 and MUC5B mRNA expression. LPS (100 ng/mL) significantly activated the phosphorylation of extracellular signal related kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK). Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK. In the primary cultures of normal nasal epithelial cells, delphinidin (50 and 100 microM) significantly inhibited LPS-induced TLR4, MUC8, and MUC5B gene expression. CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells. These findings indicated that delphinidin may be a therapeutic agent for control of inflammatory airway diseases.
Anthocyanins ; Epithelial Cells* ; Gene Expression ; Humans ; Immunoenzyme Techniques ; Lipopolysaccharides ; p38 Mitogen-Activated Protein Kinases* ; Phosphorylation ; Phosphotransferases ; Protein Kinases ; Real-Time Polymerase Chain Reaction ; RNA, Messenger ; RNA, Small Interfering ; Toll-Like Receptor 4 ; Toll-Like Receptors*