1.Aging Process of Cell.
Journal of the Korean Medical Association 1997;40(10):1300-1306
No abstract available.
Aging*
2.MR Imaging of Intracranial Calcification; Experimental and Clinical Studies.
Heoung Keun KANG ; Jeong Jin SEO ; Yun Hyeon KIM ; Jong Hoon YOON ; Byung Jin KIM ; Sung Yeul YANG
Journal of the Korean Radiological Society 1995;32(5):703-710
PURPOSE: This study was performed to evaluate MR signal intensity(SI) of calcification and to assess the capability of MRI in detection of various intracranial calcifications. MATERIALS AND METHODS: The MR findings and ROI value of experimental model of calcium carbonate suspension according to each concentration (20, 35, 50%) and diameter (1-10 mm) and hydroxyapatite suspension according to each concentration (10, 20, 30, 40, 50%) were analyzed. A specimen of calcification in cranio-pharyngioma was analyzed for its composition by XRD(X-ray diffractometer) and ICP(inductively coupled plasma) methods. MRI of 34 patients with intracranial calcifications were retrospectively analyzed for signal intensity of the calcification and its capability to detect calcifications according to size, location, and contrast with adjacent lesion. RESULTS: The calcium carbonate phantom with larger diameter and low concentration showed lower signal intensity on T2 than TlWl. Hydroxyapatite phantom showed high signal intensity in 10-30% concentration and low signal intensity in 40-50% concentration on T1 weighted image. The 5 cases of 34 intracranial calcifications showed high signal intensity on T1 weighted image. The capability of MRI in the detection of intracranial calcifications decreased in the circumstances such as small size(<2.5mm) and intraventricular location. Although the size of calcification was small, the detection was easy in the good contrast with adjacent lesion. However, the detection of the small sized calcification was easy if the contrast with adjacent lesion was good. CONCLUSION: lntracranial calcification shows generally low signal intensity on T1 and T2 weighted image with the exception of occasional high SI on TlWl. Detection of intracranial calcification in MRI is affected by its composition, size, location, and contrast with adjcent lesion.
Calcium Carbonate
;
Durapatite
;
Humans
;
Magnetic Resonance Imaging*
;
Models, Theoretical
;
Retrospective Studies
3.Treatment outcomes of extended-field radiation therapy for thoracic superficial esophageal cancer.
Doo Yeul LEE ; Sung Ho MOON ; Kwan Ho CHO ; Tae Hyun KIM ; Moon Soo KIM ; Jong Yeul LEE ; Yang Gun SUH
Radiation Oncology Journal 2017;35(3):241-248
PURPOSE: To evaluate the efficacy and safety of extended-field radiation therapy for patients with thoracic superficial esophageal cancer (SEC). MATERIALS AND METHODS: From May 2007 to October 2016, a total of 24 patients with thoracic SEC (T1a and T1b) who underwent definitive radiotherapy and were analyzed retrospectively. The median total radiotherapy dose was 64 Gy (range, 54 to 66 Gy) in conventional fractionation. All 24 patients received radiotherapy to whole thoracic esophagus and 23 patients received elective nodal irradiation. The supraclavicular lymph nodes, the celiac lymph nodes, and both of those nodal areas were included in 11, 3, and 9 patients, respectively. RESULTS: The median follow-up duration was 28.7 months (range 7.9 to 108.0 months). The 3-year overall survival, local control, and progression-free survival rates were 95.2%, 89.7%, and 78.7%, respectively. There were 5 patients (20.8%) with progression of disease, 2 local failures (8.3%) and 3 (12.5%) regional failures. Three patients also experienced distant metastasis and had died of disease progression. There were no treatment-related toxicities of grade 3 or higher. CONCLUSION: Definitive extended-field radiotherapy for thoracic SEC showed durable disease control rates in medically inoperable and endoscopically unfit patients. Even extended-field radiotherapy with elective nodal irradiation was safe without grade 3 or 4 toxicities.
Disease Progression
;
Disease-Free Survival
;
Esophageal Neoplasms*
;
Esophagus
;
Follow-Up Studies
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis
;
Radiotherapy
;
Retrospective Studies
4.Treatment outcomes of extended-field radiation therapy for thoracic superficial esophageal cancer.
Doo Yeul LEE ; Sung Ho MOON ; Kwan Ho CHO ; Tae Hyun KIM ; Moon Soo KIM ; Jong Yeul LEE ; Yang Gun SUH
Radiation Oncology Journal 2017;35(3):241-248
PURPOSE: To evaluate the efficacy and safety of extended-field radiation therapy for patients with thoracic superficial esophageal cancer (SEC). MATERIALS AND METHODS: From May 2007 to October 2016, a total of 24 patients with thoracic SEC (T1a and T1b) who underwent definitive radiotherapy and were analyzed retrospectively. The median total radiotherapy dose was 64 Gy (range, 54 to 66 Gy) in conventional fractionation. All 24 patients received radiotherapy to whole thoracic esophagus and 23 patients received elective nodal irradiation. The supraclavicular lymph nodes, the celiac lymph nodes, and both of those nodal areas were included in 11, 3, and 9 patients, respectively. RESULTS: The median follow-up duration was 28.7 months (range 7.9 to 108.0 months). The 3-year overall survival, local control, and progression-free survival rates were 95.2%, 89.7%, and 78.7%, respectively. There were 5 patients (20.8%) with progression of disease, 2 local failures (8.3%) and 3 (12.5%) regional failures. Three patients also experienced distant metastasis and had died of disease progression. There were no treatment-related toxicities of grade 3 or higher. CONCLUSION: Definitive extended-field radiotherapy for thoracic SEC showed durable disease control rates in medically inoperable and endoscopically unfit patients. Even extended-field radiotherapy with elective nodal irradiation was safe without grade 3 or 4 toxicities.
Disease Progression
;
Disease-Free Survival
;
Esophageal Neoplasms*
;
Esophagus
;
Follow-Up Studies
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis
;
Radiotherapy
;
Retrospective Studies
5.The Weaning Method of inhaled Nitric Oxide.
Hyun Woo LEE ; Jae Woong LEE ; Sung Yeul HYUN ; Ha Chang LEE ; Chul Hyun PARK ; Kook Yang PARK ; Hyeon Su YOO ; Kyung Cheon LEE ; Young Jin JANG
Journal of the Korean Pediatric Society 2001;44(4):413-417
PURPOSE: inhaled nitric oxide(iNO) is an excellent method for the postoperative pulmonary hypertension in congenital heart disease. But more detailed care is needed because of the development of rebound pulmonary hypertension after NO Withdrawal. We performed this study in order to discontinue the iNO successfully by way of presenting the adequate weaning and supplying methods. METHODS: Between January, 1998 and August, 1999 we sudied 10 patients who had rebound pulmonary hypertension(RPH) after iNO withdrawal. We completed the iNO in these patween the first the second trial of the weaning process. We tried to discover the differences between the first and second weaning process. We measured NO concentration at the start and just before NO withdrawal and during the period of weaning process. Moreover, to identify the iNO effects during the weaning of the iNO, we counted the degree of the change of PaO2/FiO2and mean PAP/SAP beween initial and at half of the initial NO concentration. RESULTS: Second weaning had a longer duration weaning process(11+/-0 cersus 5+/- hours, P<0.05), lower NO concentration just before NO withdrawal(2+/-.6 versus 4+/-ppm, P<0.05). In the change of the mean PAP/SAP and PaO2/FiO2as iNO was weaning from the initial iNO concentration to a half of the initial iNO concentration, the degree of increase in mean PAP/SAP(0.026+/-.07 versus 0.054+/-.07, P<0.05) and the degree of decrease in PaO2/FiO2(49+/-4 versus 65+/-2, P<0.05) were smaller in the second in the second weaning process than the first weaning process. CONCLUSION: A successful weaning of iNO can be performed with a low iNO concentration at the start and just before withdrawal and with the long duration iNO weaning process. Moreover, We speculate that the degree of change in the mean PAP/SAP and PaO2/FiO2at the half of the iNO weaning process are an indicator for the development of RPH.
Heart Defects, Congenital
;
Humans
;
Hypertension, Pulmonary
;
Nitric Oxide*
;
Weaning*
6.Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
Sung Yeul YANG ; Thi Thinh NGUYEN ; Trong Thuan UNG ; Young Do JUNG
Chonnam Medical Journal 2017;53(3):178-186
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates with tumorigenic phenotypes of gastric cancer and a poor survival rate in advanced gastric cancer patients. In this review, we focus on recent evidence of the aberrant expression and activation of RON in gastric cancer tumors and provide insights into the mechanism of RON signaling associated with gastric cancer progression and metastasis. Current therapeutics against RON in gastric cancer are summarized.
Epidemiologic Studies
;
Humans
;
Neoplasm Metastasis
;
Phenotype
;
Protein-Tyrosine Kinases
;
Proto-Oncogene Proteins c-met
;
Stomach Neoplasms
;
Survival Rate
7.Individualized Tumor Response Testing for Prediction of Response to Paclitaxel and Cisplatin Chemotherapy in Patients with Advanced Gastric Cancer.
Jee Hyun KIM ; Keun Wook LEE ; Yeul Hong KIM ; Kyung Hee LEE ; Do Youn OH ; Joonhee KIM ; Sung Hyun YANG ; Seock Ah IM ; Sung Ho CHOI ; Yung Jue BANG
Journal of Korean Medical Science 2010;25(5):684-690
The purpose of our study was to determine the most accurate analytic method to define in vitro chemosensitivity, using clinical response as reference standard in prospective clinical trial, and to assess accuracy of adenosine triphosphate-based chemotherapy response assay (ATP-CRA). Forty-eight patients with chemo-naive, histologically confirmed, locally advanced or metastatic gastric cancer were enrolled for the study and were treated with combination chemotherapy of paclitaxel 175 mg/m2 and cisplatin 75 mg/m2 for maximum of six cycles after obtaining specimen for ATP-CRA. We performed the receiver operator characteristic curve analysis using patient responses by WHO criteria and ATP-CRA results to define the method with the highest accuracy. Median progression free survival was 4.2 months (95% confidence interval [CI]: 3.4-5.0) and median overall survival was 11.8 months (95% CI: 9.7-13.8) for all enrolled patients. Chemosensitivity index method yielded highest accuracy of 77.8% by ROC curve analysis, and the specificity, sensitivity, positive and negative predictive values were 95.7%, 46.2%, 85.7%, and 75.9%. In vitro chemosensitive group showed higher response rate (85.7% vs. 24.1%) (P=0.005) compared to chemoresistant group. ATP-CRA could predict clinical response to paclitaxel and cisplatin chemotherapy with high accuracy in advanced gastric cancer patients. Our study supports the use of ATP-CRA in further validation studies.
Adenosine Triphosphate/*analysis
;
Adult
;
Aged
;
Antineoplastic Agents, Phytogenic/administration & dosage
;
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
;
Cisplatin/administration & dosage
;
Drug Screening Assays, Antitumor/*methods
;
Female
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Outcome Assessment (Health Care)/methods
;
Paclitaxel/administration & dosage
;
Reproducibility of Results
;
Sensitivity and Specificity
;
Stomach Neoplasms/*diagnosis/*drug therapy/metabolism
;
Treatment Outcome
8.The effect of ozone exposure on antioxidant responses in murine model of asthma.
An Soo JANG ; Inseon S CHOI ; Sung Yeul YANG ; June Hyuk LEE ; Sung Woo PARK ; Soo Taek UH ; Yong Hoon KIM ; Choon Sik PARK
Journal of Asthma, Allergy and Clinical Immunology 2003;23(4):749-758
BACKGROUND AND OBJECTIVE: Ozone exposure has been shown to modify the protective antioxidant defense network in the respiratory tract. The aim of the present study was to evaluate the effects of ozone exposure on antioxidant status in murine model of asthma. METHODS: Enhanced pause of breathing (Penh) as marker of airway obstruction was measured to determine whether bronchoconstriction occurred in BALB/c mice using barometric whole-body plethysmography after ozone and ovalbumin (OVA) exposure. Antioxidant levels were determined using high performance liquid chromatography with electrochemical detection in bronchoalveolar lavage (BAL) fluid and lung tissue homogenates. RESULTS: Uric acid and gamma-tocopherol concentrations were significantly increased in BAL fluid following ozone and OVA exposure (p<0.01). Malondialdehyde concentrations in lung tissue homogenates were significantly increased in ozone and OVA exposed group than in the saline exposed group (p<0.05). Uric acid concentrations were increased in ozone and OVA exposed group than in the saline exposed group. Increases in Penh were significantly higher in ozone and OVA exposed group than in saline exposed group. The proportion of neutrophils in BAL fluid was significantly higher in ozone exposed group than in saline exposed group (p<0.01). The level of ascorbate was correlated with the level of gamma-tocopherol (r=0.65, p<0.05). Penh was not related with antioxidant responses. CONCLUSION: The data indicate that antioxidant responses may serve as protective mechanism to minimize the effects of ozone exposure in murine model of asthma.
Airway Obstruction
;
Animals
;
Antioxidants
;
Asthma*
;
Bronchoalveolar Lavage
;
Bronchoconstriction
;
Chromatography, Liquid
;
gamma-Tocopherol
;
Lung
;
Malondialdehyde
;
Mice
;
Neutrophils
;
Ovalbumin
;
Ovum
;
Ozone*
;
Plethysmography
;
Respiration
;
Respiratory System
;
Uric Acid
9.Pitfalls of ABO Genotyping Based on Targeted Single Nucleotide Variant Analysis Due to a Nondeletional O Allele Lacking c.261delG: First Report of ABO*O.09.01 in Korea
Dahae YANG ; Boram KIM ; Da Young SONG ; Tae Yeul KIM ; Man Jin KIM ; Sung Im CHO ; Hyungsuk KIM ; Moon Woo SEONG ; Sung Sup PARK
Annals of Laboratory Medicine 2019;39(6):599-601
10.Antioxidant Action of Transthyretin in Human Cerebrospinal Fluid.
Sung Yeul YANG ; Kee Oh CHAY ; Jong Geun PARK ; Moon Hee RYU ; Suck Noh HONG ; Soo Han KIM ; Bong Whan AHN ; Je Hyuk LEE ; Min Wha LEE
Journal of Korean Neurosurgical Society 1994;23(4):375-381
Protective effect of human cerebrospinal fluid antioxidants against enzyme inactivation caused by metal-catalyzed oxidation systems were investigated. When purified glutamine synthetase(GS) was incubated with human cerebrospinal fluid(CSF), the enzyme was progressively inactivated. Catalase and EDTA could inhibit the enzyme inactivation by 50-80%. Small-molecular(Mr<-10,000) fraction of CSF inactivated the exogenous GS, but large-molecular(Mr>-10,000) fraction did not. The GS inactivation by the small-molecular fraction was also markedly inhibited by catalase and EDTA. These results suggested that metal-catalyzed oxidation is involved in the GS inactivation by the small-molecular fraction of CSF. Dithiothreitol(DTT)was shown to inhibit almost completely the oxidative inactivation of GS by CSF. However, DTT inhibited only partially the oxidative inactivation of GS caused by small-molecular fraction of CSF. When large-molecular fraction of CSF was separated by anion-exchange HPLC chromatography, there was a peak of antioxidant activity inhibiting the small-molecular fraction-induced GS inactivation in the presence of DTT. The antioxidant activity was neutralized by monoclonal antibodies to transthyretin. Purified transthyretin was found to efficiently inhibit ascorbate/Cu2+-induced GS inactivation in the presence of DTT. Uric acid and glucose did not shoe any protective effect on the GS inactivation in the same condition. The above results suggest that metal-catalyzed oxidation occurs normally in human CSF, and the transthyretin may play an important role as a CSF antioxidant in protecting proteins from metal-catalyzed oxidation.
Antibodies, Monoclonal
;
Antioxidants
;
Catalase
;
Cerebrospinal Fluid*
;
Chromatography
;
Chromatography, High Pressure Liquid
;
Edetic Acid
;
Glucose
;
Glutamine
;
Humans*
;
Prealbumin*
;
Shoes
;
Uric Acid