A putative polypeptide hormone identified as amylin[islet amyloid polypeptide] is synthesized and co-localized with insulin in B cells of pancreatic islets in several animal species including man. However, there is growing evidence that somatostatin cells are also expressed and contained amylin in the pancreatic islets of the rat The aim of the present study was to investigate the immunocytochemical expression of the amylin within the endocrine pancreas of the man, rabbit and guinea pig, with special reference to the possible ability of islet cells other than insulin cells to synthesize amylin. For this purpose serial sections of the pancreatic islets were stainedimmunocytochemically using anti-amylin, anti-insulin, anti-glucagon, anti-somatostatin antisera. In serial sections of pancreatic islets of the man and rabbit, it was shown that amylin immunoreactivity occurred in insulin-reactive B cells predominantly located in interior of the islets. In contrast, amylin immunoreacivity appeared in glucagon-reactive A cells peripherally located in the islets of the guinea pig. These results suggest that in both the man and rabbit, amylin is synthesized by B cells for subsequent co-secretion with insulin, and that in guinea pig, amylin is synthesized by A cells for co-secretion with glucagon. It thus appears that amylin release may be mediated by different secretory mechanisms according to animal species.
Amyloid ; Animals ; B-Lymphocytes ; Glucagon ; Guinea Pigs* ; Guinea* ; Immune Sera ; Immunohistochemistry ; Insulin ; Islet Amyloid Polypeptide* ; Islets of Langerhans* ; Rats ; Somatostatin-Secreting Cells

No abstract available.
Humans ; Kidney Failure, Chronic* ; Peritoneal Dialysis, Continuous Ambulatory*

The complications of peripheral or posterioruveitis, such as vitreous opacity, epiretinal membrance, and tractional retinal detachment may need vitreous surgery. This study was undertaken to evaluate the efficacy of transpars plana vitrectomy in the case of epiretinal membrance or tractional retinal detachment secondary to chronic uveitis.We included 23 eyes of 21 patients, and among them there was 16 eyes of epiretinal membrance and 7 eyes of tractional retinal detachment respectively. Improvement of vision, 2 lines or more in Anellen Chart, was noted in 10 eyes(63%) for epiretinal membrance and 2 eyes(29%) for tractional retinal detachment within post-operative 1 month. Final visual acuity decrease, compared with preoperative vision, was noted in 4 eyes(25%) for epiretinal membrance and 6 eyes(86%) for tractional retinal detachment with a mean follow-up of 34 months. The most common cause of visual acuity decrease was recurrent or persistent inflammation and resultant fibrous tissue proliferation, which became obvious within post-operative 3 months.Therefore, we`re able to conclude that the main cause of postoperative visual acuity decrease is persistent intraocular inflammation and fibrous change. So it is necessary to remove posterior hyaloid membrance actively and combine with medical treatment like corticosteroid therapy in order to control the inflammation even after vitreous surgery.
Follow-Up Studies ; Humans ; Inflammation ; Retinal Detachment ; Traction ; Uveitis* ; Visual Acuity ; Vitrectomy*

No abstract available.
Kidney* ; Neuroectodermal Tumors, Primitive*

No abstract available.
Histiocytosis*

No abstract available.
Neurofibromatoses* ; Peripheral Nerves*

BACKGROUND: To evaluate the clinical and functional outcomes of arthroscopic-assisted reduction and percutaneous screw fixation for glenoid fractures with scapular extension, and investigate the radiologic and clinical benefits from the results. METHODS: We evaluated patients treated with arthroscopic-assisted reduction and percutaneous screw fixation for glenoid fractures with scapular extension from November 2008 to September 2015. Fractures with displacement exceeding one-fourth of the anterior-articular surface or more than one-third of the posterior-articular surface in radiographic images were treated by surgery. Clinical assessment was conducted based on range of motion, Rowe score, and Constant score of injured arm and uninjured arm at last follow-up. RESULTS: Fifteen patients with Ideberg classification grade III, IV, and V glenoid fracture who underwent arthroscopic-assisted reduction using percutaneous screw fixation were retrospectively enrolled. There were no differences in clinical outcomes at final follow-up compared to uninjured arm. Bone union was seen in all cases within five months, and the average time to bone union was 15.2 weeks. Ankylosis in one case was observed as a postoperative complication, but the symptoms improved in response to physical therapy for six months. There was no failure of fixation and neurovascular complication. CONCLUSIONS: We identified acceptable results upon radiological and clinical assessment for the arthroscopic-assisted reduction and percutaneous fixation. For this reason, we believe the method is favorable for the treatment of Ideberg type III, IV, and V glenoid fractures. Restoration of the articular surface is considered to be more important than reduction of fractures reduction of the scapula body.
Ankylosis ; Arm ; Arthroscopy ; Classification ; Follow-Up Studies ; Fracture Fixation ; Glenoid Cavity ; Humans ; Methods ; Postoperative Complications ; Range of Motion, Articular ; Retrospective Studies ; Scapula

No abstract available.
Cyclosporine* ; Humans ; Vitiligo*

No abstract available.
Cicatrix, Hypertrophic* ; Skin*

No abstract available.
Gastrointestinal Neoplasms* ; Thymidine Kinase* ; Thymidine*