1.Comparison of Results between Tuberculin Skin Test and QuantiFERON(R)-TB In-Tube Assay for Diagnosis of Latent Tuberculosis Infection in Children and Adolescents.
Jong Won CHOI ; Min Sung KIM ; Jong Hyun KIM
Korean Journal of Pediatric Infectious Diseases 2013;20(1):17-27
PURPOSE: Recently, two tests are commercially available for the identification of latent tuberculosis infection (LTBI): tuberculin skin test (TST) and interferon-gamma release assay (IGRA). Due to its false positiveness, TST tends to be preferred by IGRA until now. In our study, we simultaneously performed both TST and QuantiFERON(R)-TB Gold In-Tube (QFT-GIT) and compared their results. METHODS: TST and QFT-GIT were done for the diagnosis of LTBI among children who visited pediatric out-patient clinic at St. Vincent's Hospital, The Catholic University of Korea from February of 2007 to May of 2008. The study group was stratified into two groups in terms of whether there was intrafamilial contact or not. RESULTS: Out of total 35 children, 29 were tuberculosis (TB)-exposed cases and the remainders were diagnosed as clinical pulmonary TB. Among these 29 children, TST was positive 38.9% (7/18) for the intrafamilial and 45.5% (5/11) for the non-intrafamilial, and at the same time, the result for QFT-GIT was positive 5.6% (1/18) and 9.1% (1/11), respectively which implies that TST was more sensitive than QFT-GIT. Among 29 TB-exposed cases, 26 initially went through TST and QFT-GIT together on their first visit to out-patient clinic, and 15 continued the follow-up tests. Out of total 41 cases collected, the agreement (known as kappa value) was 0.063 which was relatively low. Including 6 cases with pulmonary TB who were all positive for TST and only 5 being positive for QFT-GIT, the final kappa value was 0.334. CONCLUSION: In our study, the agreement for TST and QFT-GIT was low, and the majorities were almost the cases of positive TST. In current situation with lacking a gold standard test and limited data on children to adolescents, this result is quite alarming that the recent trend tends to replace TST by QFT-GIT when diagnosing LTBI.
Adolescent
;
Child
;
Follow-Up Studies
;
Humans
;
Interferon-gamma Release Tests
;
Korea
;
Latent Tuberculosis
;
Outpatients
;
Skin
;
Skin Tests
;
Tuberculin
;
Tuberculosis
2.Muscular Hamartoma of the Breast: A case report.
Dong Won MIN ; Sun Hee SUNG ; In Joon CHOI
Korean Journal of Pathology 1994;28(1):86-89
Hamartoma of the breast is relatively rare benign tumor, which is a well-circumscribed mass mainly composed of fibrous stroma, a(tipose tissue, ducts and acini. Muscular hamartoma of the breast is mainly composed of smooth muscle, and is extremely rare because proper smooth muscle is normaly absent in the breast except in the nipple. We describe a rare case of muscular hamartoma of the breast in a 38-year-old woman. This tumor was located in the upper outer quadrant and a 3 x 2.5 x 2 cm sized, well-demarcated but not encapsulated mass, The mass consisted mainly of irregularly arranged smooth muscle bundles in the fibrous stroma with lobular units and admixed fat cells. The origin of smooth muscle in hamartoma is not well known.
Female
;
Humans
;
Hamartoma
3.Gluteus Maximus Myocutaneous Flaps for Repair of the Sacral Pressure Sores
Chang Soo KANG ; Sung Won SOHN ; Byung Woo MIN
The Journal of the Korean Orthopaedic Association 1987;22(6):1361-1366
It would be naive to assume that any operative procedure is the solution to the problem of sacral pressure sore in the field of the orthopaedic surgery. The procedures outlined here involve the creation of compound myocutaneous flaps of the gluteus maximus muscle, skin, and the subcutaneous tissue. The myocutaneous flap us- ing the gluteus maximus muscle is a vascular flap instead of a random flap, with better blood supply for healing and advantage of an increased amount of cushion effect. We present an alternative method which will provide satisfactory and substantial soft tissue coverage in sscral pressure sores.
Methods
;
Myocutaneous Flap
;
Pressure Ulcer
;
Skin
;
Subcutaneous Tissue
;
Surgical Procedures, Operative
4.Quadricepsplasty and arthrolysis in stiff knee.
Sung Won SOHN ; Woo Yul LEE ; Byung Woo MIN
Journal of the Korean Knee Society 1992;4(1):69-79
No abstract available.
Knee*
5.A Clinical Study of the Subacute Osteomylitis in Children
Sung Joon KIM ; Kuhn Sung WHANG ; Tai Seung KIM ; Sung Chul AHN ; Won Min CHO
The Journal of the Korean Orthopaedic Association 1994;29(2):431-439
Subacute osteomylitis is far less common than acute osteomyelitis, characterized by insidious onset of the symptoms of mild local pain or discomfort without any acute systemic illness. Radiographic findings are not infrequently confused with benign or malignant bone tumors. From Jan, 1983 to Dec. 1991, we experienced twelve patients with subacute osteomylitis of long bones. Our clinical observations were as follows. 1. There were 11 boys and one girl with an average age of 9.7 years(range, 30months-16years). 2. The involved sites were proximal in 1, distal radius in 3, midshaft of femur in 3, distal femur in 2, proximal tibia in 1, and distal tibia in 2 cases. 3. All patients had insidious onset of mild to moderate pain. ESR was increased in 9 cases(75%) with a mean value of 44 mm/hr, but leukocytosis was not found. 4. According to the Green and Edwards' classification, there were type 1 in 1, type 2 in 3, type 3 in 3, and type 6 in 5 cases. 5. Eleven patients had operative treatment. The remaining one patient was treated by antibiotic treatment. 6. Primary treatment was successful in 11 patients who were followed for and average 9.5 months. One patients was lost to follow-up.
Child
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Classification
;
Clinical Study
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Female
;
Femur
;
Humans
;
Leukocytosis
;
Lost to Follow-Up
;
Osteomyelitis
;
Radius
;
Tibia
6.The Effect of Single Dose Imipramine on Nocturnal Urine Output in Patients with Nocturnal Enuresis.
Won Jung KIM ; Min Jung KIM ; Byeong Hee SON ; Sung Won KIM
Journal of the Korean Pediatric Society 2000;43(6):792-797
PURPOSE: The aim of the present study was to investigate the effect of single dose imipramine on nocturnal urine output in patients with nocturnal enuresis. METHODS:A total of 6 monosymptomatic enuretic patients of more than 5 years of age were enrolled in this study. We measured nocturnal urine output, urine osrnolality, creatinine clearance, osmolal clearance, excretion rate of solutes, fractional excretion of sodium and potassium, and plasma vasopressin with and without a single oral dose of imipramine(lmg/kg of body weight) at 8 p.m. RESULTS: The administration of imipramine was followed by a significant decrease in noctumal urine output(P=0.02). Urine osmolality was not significantly increased(P>0.05), but osmolal clearance was significantly decreased during imipramine medication(P=0.03). Urinary excretion rate of sodium and potassium showed a statistically insignificant trend toward lower values during imipramine administration in nocturnal enuretics. Fractional urinary excretion of sodium and potassium was significantly decreased during imipramine medication(P<0.05). There was no significant difference in plasma vasopressin level and creatinine clearance in nocturnal enuretics after imipramine. CONCLUSION: Imipramine has a vasopressin independent antidiuretic effect in patients with nocturnal enuresis. The antidiuretic effect of imipramine can be attributed prirnarily to increased a-adrenergic stimulation in the proximal tubules with secondary increased urea and water reabsorption more distally in the nephron. (J Korean Pediatr Soc 2000;43:792 - 797)
Antidiuretic Agents
;
Creatinine
;
Enuresis
;
Humans
;
Imipramine*
;
Nephrons
;
Nocturnal Enuresis*
;
Osmolar Concentration
;
Plasma
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Potassium
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Sodium
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Urea
;
Vasopressins
7.Detection of human cytomegalovirus DNA polymerase gene by polymerase chain reaction.
Hyun Chul KIM ; Sung Bae PARK ; Won Hyun CHO ; Won Ki BAEK ; Min Ho SUH
Journal of the Korean Society for Microbiology 1992;27(2):181-188
No abstract available.
Cytomegalovirus*
;
DNA*
;
Humans*
;
Polymerase Chain Reaction*
8.Two Cases of Successful Treatment with Atropine Sulfate in Persistent Vomiting beyond Pyloromyotomy of Infantile Hypertrophic Pyrolic Stenosis .
Won Jung KIM ; Min Jung KIM ; Woo Jae JO ; Jae Young KIM ; Sung Won KIM
Journal of the Korean Pediatric Society 2000;43(5):704-709
Infantile hypertrophic pyloric stenosis (IHPS) is the most common condition requiring abdominal surgery in early infancy, and is caused by hypertrophied pyloric muscle. The development of successful surgical treatment in the early 1900s by Fredet and Ramstedt made it possible for infants worldwide to survive. Modern pediatric anesthetic techniques have virtually eliminated mortality from surgical management. Atropine sulfate is a cholinergic blocking agent with potent antimuscarinic activity that decreases peristaltic contractions by relaxing smooth muscles. We treated two cases of IHPS with incomplete pyloromyotomy in 3-month-old and 5-month-old male infants by administering atropine sulfate intravenously. They were free from vomiting after 5 days of intravenous atropine sulfate treatment. In these rare cases of persistent vomiting or refractory emesis following incomplete pyloromyotomy, there may be a role for atropine sulfate.
Atropine*
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Constriction, Pathologic*
;
Humans
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Infant
;
Male
;
Mortality
;
Muscle, Smooth
;
Pyloric Stenosis, Hypertrophic
;
Vomiting*
9.4 Cases of Pseudomembranous Colitis Confirmed by Clostridium Culture.
Nam Min LEE ; Jong Ho WON ; Moon Sung LEE ; Jin Hong KIM ; Sung Won CHO ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 1989;9(2):221-226
Diarrhea is a common complication of antibiotics usage. The diarrhea ascribed to antibiotics usually consist of loose or watery stools, sometimes containing mucus but rarely grossly evident blood. Almost every antibiotics has been implicated, although cases related to the use of vancomycin or aminoglycosides are rare. Although the pathogenesis of antibiotics-associated diarrhea is not confirmed, recent studies have shown that a toxin of clostridium difficile is implicated as a cause of it. Diagnosis is made by detecting toxin in the stool or stool culture for C.difficile. Treatment is either directed at binding the toxin with anion exchange resins such as cholestyramine in mild case, or at eradicating the C.difficile organism with vancomycin, metronidazole or bacitracin for more severe cases. (continue...)
Aminoglycosides
;
Anion Exchange Resins
;
Anti-Bacterial Agents
;
Bacitracin
;
Cholestyramine Resin
;
Clostridium difficile
;
Clostridium*
;
Diagnosis
;
Diarrhea
;
Enterocolitis, Pseudomembranous*
;
Metronidazole
;
Mucus
;
Vancomycin
10.Porokeratosis Ptychotropica: A Lesser-known Variant of Porokeratosis
Hoo Min CHOI ; Sung Min KIM ; Jae Won KANG ; Byung In RO ; Han Kyoung CHO
Korean Journal of Dermatology 2019;57(9):562-563
No abstract available.
Porokeratosis