No abstract available.
Peripheral Blood Stem Cell Transplantation*

No abstract available.

No abstract available.

No abstract available.
Health Promotion* ; Primary Health Care*

A gastric carcinoma is the commonest malignancy in Korea and the purpose of this study is: a. to predict the prognosis of gastric carcinoma patient preoperatively b. to gastrectomize as minimally as possible to reduce postoperative morbidity c. to compare a radiologic findings with an endoscopic, gross and pathologic features. And two representative cases are presented here and the invasion depth and extent of the gastric carcinoma of the stomach is evaluated and discussed with the review of articles.
Humans ; Korea ; Prognosis ; Stomach

Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and behavioral changes that were demonstrated in these transgenic mice model were amyloid changes, gliotic changes. A-beta increases, deficit in LTP(ling-term potentiation) and behavioral changes. Some or all of the above changes were found in each transgenic mice model. These models generally showed amyloid neuropathology but they usually lacked the neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's disease. The development of them is undoubtedly the great progress toward future research.
Alzheimer Disease ; Amyloid ; Animals* ; Dementia* ; Mice ; Mice, Transgenic ; Models, Animal* ; Neurofibrillary Tangles ; Neurons ; Presenilins

No abstract available.
Anesthesia* ; Liver Transplantation*

No abstract available.
Knee*

The one event on signaling mechanism is the cleavage by adenyl cyclase of ATP into second messenger, cyclic AMP. The other transfer system of inositol metabolism, it is widely recognized that hydrolysis of the minor membrane lipid phosphoinositide bisphosphate (PIP₂) initiated by occupation of certain receptors and catalyzed by phospholipase C, lead to toe generation of the two intracellular messengers, inositol triphosphate (IP₃) and diacylglycerol (DG). IP₃ is converted to inositol tetrakisphosphate (IP₄) by IP₃ kinase. In the present study, it is that purification of calmodulin is used by phenyl-Sepharose CL-4B chromatography, it's molecular weigh, 17,000 in SDS-polyacrylamide gel electrophoresis. In order to observe the affinity between calmodulin (CaM)-Affigel 15 and IP₃ kinase, and isolated IP₃ kinase, was applied in CaM-Affigel with Ca²⁺ equilibrium buffer and EGTA equilibrium buffer. We compared with binding and elution effect of IP₃ kinase in several condition of buffer. In affinity of binding, Ca²⁺ equilibrium buffer was in the most proper condition, and elution, CaM/Ca²⁺buffer (CE 1 10.36, CE2 12.76pM/min/mg of protein) was effected much more than EGTA buffer (E2 1.48, E 2.43pM/min/mg of protein), but CaM/Ca²⁺stimulate the activity of IP₃ kinase. And then, several detergents such as sodium deoxycholate, tween 20, cholic acid, polyethylene glycol, chaps were applied. The 0.2% chaps buffer (E2 23.19, E3 8.05pnM/min/mg of protein) was the most effective in elution of IP3 kinase.
Adenosine Triphosphate ; Adenylyl Cyclases ; Brain* ; Calmodulin ; Cholic Acid ; Chromatography ; Cyclic AMP ; Deoxycholic Acid ; Detergents ; Egtazic Acid ; Electrophoresis ; Hydrolysis ; Inositol* ; Membranes ; Metabolism ; Occupations ; Phosphotransferases* ; Polyethylene Glycols ; Polysorbates ; Second Messenger Systems ; Toes ; Type C Phospholipases

In order to grasp the real status of male sterility of the Koreans, clinical observation, semen analysis, and testicular biopsy were conducted on 257 cases. the study was performed in the Department of Urology, Kyungpook National University School of Medicine during the period from April 1963 to March 1968 for5 years. 1) The 257 cases complained of sterility occupied 4.3% of the total number of outpatients, 5927. visited during the observation period. 2) The age range of the cases applied was from 55, maximum, to 21. minimum, with the category of 26 to 35 occupying 2/3 of the whole. 3) The majority of the cases were in the 2nd to 5th year of their marriages 10.8%. 4) Cities were found to produce more of such cases than the country. and no specific relationship was revealed to be connected with patient's occupations. 5) Tuberculous diseases weremore prevalent in the past histories of those involved, and gonorrhea and mumps showed a decreasing tendency. 6) 141 cases (55.2%) produced 2 to 4ml of semen amount and 40 cases, less than 1.0ml. 7) 90 cases (35.O%) were found have azoospermia and 122 cases (47.7%) had more than 50 X 10(6) sperms, 8) 106 cases (63.5%) had higher than 60% of active sperm while 16 cases showed to have less than 20%. 9) Findings of testicular biopsies were conducted on 35 cases with azoospermia of oligospermia: Germinal cell aplasia-17 cases (48.6%); spermatogenic arrest-10 cases (28.6%); hypospermatogenesis-6 cases (17.1%); normal-2 cases.
Azoospermia ; Biopsy ; Gonorrhea ; Gyeongsangbuk-do ; Hand Strength ; Humans ; Infertility ; Infertility, Male* ; Male ; Male* ; Marriage ; Mumps ; Occupations ; Oligospermia ; Outpatients ; Semen ; Semen Analysis ; Spermatozoa ; Urology