Hobnail hemangioma(HH) is a benign acquired vascular tumor of endothelial origin which should be differentiated from other malignant vascular neoplasm such as Kaposi's sarcoma or angiosarcoma. We report a case of hobnail hemangioma in a 21-year-old woman who had a dusky-red patch on her left shin. Histologically, ectatic vascular channels with a single layer of plumped endothelial cells were seen and the vascular channels seemed to dissect the collagen bundles. She underwent treatment with surgical excision with primary closure.
Collagen ; Endothelial Cells ; Female ; Hemangioma* ; Hemangiosarcoma ; Humans ; Sarcoma, Kaposi ; Vascular Neoplasms ; Young Adult

Atypical cutaneous fibrous histiocytoma (ACFH) is not well known and only a small number of cases have been reported. Characteristically, ACFH is found on the trunk and limbs of middle-aged women. Although considerable cellular atypia may be present, it occurs focally, the remainder of the tumor representing more classical cutaneous fibrous histiocytoma. A 37-year-old woman presented with a solitary brownish firm nodule on her right forearm. No other abnormalities were found in her personal or family history. Clinically, the tumor simulated a benign fibrous histiocytoma. Histologic examination revealed a poorly delineated intradermal tumor with the usual appearance of benign cutaneous fibrous histiocytoma, but a variable pro-portion of cells in the tumor were scattered atypical cells or bizarre multinucleated giant cells. We report upon a rare case of ACFH.
Adult ; Extremities ; Female ; Forearm ; Giant Cells ; Histiocytoma, Benign Fibrous* ; Humans

No abstract available.
Frontal Sinus*

PURPOSE: Lymph node metastasis is an important factor for predicting the prognosis of colorectal cancer patients. However, approximately 60% of patients do not receive adequate lymph node evaluation (less than 12 lymph nodes). In this study, we identified a more effective tool for predicting the prognosis of patients who received inadequate lymph node evaluation. MATERIALS AND METHODS: The number of metastatic lymph nodes, total number of lymph nodes examined, number of negative metastatic lymph nodes (NL), lymph node ratio (LR), and the number of apical lymph nodes (APL) were examined, and the prognostic impact of these parameters was examined in patients with colorectal cancer who underwent surgery from January 2004 to December 2011. In total, 806 people were analyzed retrospectively. RESULTS: In comparison of different lymph node analysis methods for rectal cancer patients who did not receive adequate lymph node dissection, the LR showed a significant difference in overall survival (OS) and the APL predicted a significant difference in disease-free survival (DFS). In the case of colon cancer patients who did not receive adequate lymph node dissection, LR predicted a significant difference in DFS and OS, and the APL predicted a significant difference in DFS. CONCLUSION: If patients did not receive adequate lymph node evaluation, the LR and NL were useful parameters to complement N stage for predicting OS in colon cancer, whereas LR was complementary for rectal cancer. The APL could be used for prediction of DFS in all patients.
Colonic Neoplasms ; Colorectal Neoplasms* ; Complement System Proteins ; Disease-Free Survival ; Humans ; Lymph Node Excision ; Lymph Nodes* ; Methods* ; Neoplasm Metastasis ; Prognosis* ; Rectal Neoplasms ; Retrospective Studies

OBJECTIVE: Chronic pelvic pain is pelvic pain which is not completely controlled by classical treatments. In many reports, immune alternation is related to original diseases that induce the chronic pelvic pain. Mistletoe extract has been known that it has immune modulation effect. Therefore the purpose of this study is to determine the pain-reducing effects of mistletoe extract for chronic pelvic pain that is not controlled by classical treatments. METHODS: The fitty-eight patients who visited to outpatient department of Department of Obstetrics and Gynecology, Chonnam National University Hospital due to chronic pelvic pain. Mistletoe extract (Helixor-A(R)) 5-10 mg was injected subcutaneously 3 times per week for 5 weeks, and the change of pain and short-term side-effects after injections were observed. In patients after 6 month of follow-up, the change of pain and long-term side-effects were also observed. RESULTS: In 2 of 58 patients (0.03%), treatments were discontinued doe to severe general side effect. In 48 of 56 patients (85.7%), chronic pelvic pains were improved. In 40 of 56 patients (69%), mild side effects as like mild itching were appeared and they were easily controlled by anti-histamines and conservative treatments. In 6 months after injection, general itching sensation and easily catched common cold were complaint in 4 of 10 patients. CONCLUSION: The subcutaneous injection of mistletoe extract may effective treatment method for the chronic pelvic pain that is not controlled by classical treatment. However more studies about log-term effect of mistletoe therapy are needed.
Common Cold ; Follow-Up Studies ; Gynecology ; Humans ; Injections, Subcutaneous* ; Jeollanam-do ; Mistletoe* ; Obstetrics ; Outpatients ; Pelvic Pain* ; Pruritus ; Sensation

No abstract available.
Humans ; Mucocutaneous Lymph Node Syndrome*

Extramammary Paget's disease (EMPD) typically presents as an eczematous, eroded or crusted plaque. Only a few cases with depigmentation have been reported. We herein report a patient with a depigmented scrotal patch as the sole finding of EMPD. Since he had concurrent rectal cancer, we stained the tissue with gross cystic disease fluid protein-15 (GCDFP-15) and cytokeratin 20 (CK20) in order to differentiate primary/secondary EMPD. This case represents coincidental primary EMPD and rectal cancer, of which the initial features of EMPD were unusual.
Adenocarcinoma* ; Cytochrome P-450 CYP1A1 ; Humans ; Keratin-20 ; Paget Disease, Extramammary* ; Rectal Neoplasms*

The authors present two cases of granular dystrophy of the cornea developed in 47-year-old house wife and her 27-year-old son respectively. The mother first noticed diminished vision at 23 years of age and was diagnosed as corneal dystrophy at the age 28. Her son was diagnosed as corneal dystrophy at his age 16. The disease has run a slow, torpid course, progressing without dramatic incident and inflammatory symptoms, but attack of slight epiphora and photophobia occurred as age advanced. The corneal change was characterized by the presence of miliary sized milk-white spots in the stroma mainly at the central area of the cornea. The visual acuity was progressively deteriorated over the year but not gravely reduced allowing useful activities.
Adult ; Cornea* ; Humans ; Lacrimal Apparatus Diseases ; Middle Aged ; Mothers ; Photophobia ; Spouses ; Vision, Low ; Visual Acuity

In glaucoma, we need an accurate, highly reproducible analysis method for the purpose of early detection of fine glaucomatous optic nerve head change. Nowadays many investigations using confocal laser tomographic scanner (Heidelberg Retinal Tomograph ; HRT) are actively undertaken. We analyzed the optic nerve head of 479 normal eyes(male:308, female:171) with HRT, and got the mean value of each parameter in HRT. We compared the difference between men and women. We also observed the distribution of the value of each parameter in normal adult. In addition, for the parameter of rim/disc area ratio, we got the mean value in 6 divisions of optic nerve head. The range of distribution of disc area was from 1.139 mm2 to 4.512 mm2, cup area ranged from 0.104 mm2 to 2.667 mm2, and rim area was from 0.760 mm2 to 2.925 mm2. The parameter which showed difference between men and women was height variation contour. For rim/disc area ratio, the mean value of each 6 divisions were as follows: nasal inferior, 0.909; nasal, 0.908; nasal superior, 0.860; temporal inferior, 0.763; temporal 0.519; temporal superior 0.738. We can make good use of the normal parameters of HRT in Koreans for diagnosis and treatment of glaucoma.
Adult ; Diagnosis ; Female ; Glaucoma ; Humans ; Male ; Optic Disk* ; Optic Nerve* ; Retinaldehyde

OBJECTIVE: Immune alternation is related to the pathogenesis and progression of endometriosis. Helixor-A, mistletoe extract, has been known that it has immune modulation effect. Therefore the purpose of this study is to determine the effects of Helixor-A for pain of endometriosis by intraperitoneal instillation of mistletoe extract during the diagnostic laparoscopy. METHODS: Among the paitients who visited to outpatient clinic due to chronic pelvic pain, 30 patients who had laparoscopically-confirmed endometriosis were included in this study. Helixor-A 5 mg was instilled into the posterior cul-de-sac during the diagnostic laparoscopy. Before diagnostic laparoscopy and one month after laparoscopy, the patients recorded pain scores. RESULTS: In 11 of 30 patients (36.7%), pelvic pain of endometriosis improved after laparoscopy. In 2 of 30 patients, the side-effect of Helixor- A appeared and they were easily controlled by antihistamines. CONCLUSION: The instillation of Helixor-A during diagnostic laparoscopy, that is essential for confirmation of endometriosis, may be helpful as a supportive treatment for treatment of pelvic pain due to endometriosis with classical treatment such as GnRH agonist therapy.
Ambulatory Care Facilities ; Endometriosis* ; Female ; Gonadotropin-Releasing Hormone ; Histamine Antagonists ; Humans ; Laparoscopy* ; Mistletoe* ; Pelvic Pain