The authors studied thirty-three cases of malignant tumors of the skin (24 squamous cell carcinomas, 6 basal cell carcinomas, 2 Paget's diseases and one malignant melanoma) at the department of dermatology, Pusan national university hospital during the period from 1966 to 1971. The results obtained were summarized as follows: 1) There were 21 men(63.6%) and 12 women(36.3%) in this series. 2) The average age of these patients was 56 years with a range of 33 years to 70 years. 3) The ages at onset ranged from 29 to 66 years with the peak incidence in the 50-59 years group. 4) Of the 33 cases, 28 cases were first diagnosed at the age of over 40 years. 5) The ratio of squamous cell carcinoma versus basal cell carcinoma was 4: l. 6) In 29 patients the tumors occurred on the exposed areas of the body and the most common predilection site was on the face (63.6%), of which 6 squamous cell carcinomas occurred on the upper lip. 7) Of the 30 cases of both squamous cell carcinomas and basal cell carcinomas, 20 cases (66.6%) showed ulcerative lesions measuring from less than 1cm to 10cm in diameter. 8) Two cases of the tumors (one squamous cell carcinoma and one malignant melanoma) showed metastasis at the time of diagnosis. 9) The accuracy of clinical diagnosis in this series was 96%. 10) Of the 24 cases of squamous cell carcinomas, 7 cases were treated with radiotherapy, 5 cases with curettage and electrodesiccation followed by radiotherapy. Four squamous cell carcinomas and two basal cell carcinomas that showed relatively superficial and small lesions measuring less than 1.5cm in diameter were treated with electrodesiccation and curettage and are under observation with favorable results for six months to two years.
Busan ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Curettage ; Dermatology ; Diagnosis ; Humans ; Incidence ; Lip ; Neoplasm Metastasis ; Radiotherapy ; Skin* ; Ulcer

Clinical studies on five patients with acrodermatitis enteropathica visited during the period from March 1968 to September 1970 to the department of dermatology, Pusan national University hospital were made and the results obtained were summerized as follows; in addition, the literature was reviewed. 1) All of 5 patients aging from 3 months to 3 years, showed characteristic distributions of the cutaneous lesions which ranged in character from vesicobullous to heavily scaled psoriasiform and moniliasis-like lesions. 2) Of these, the nearly full clinical pictures were presented in two cases with the gradual onset in early infancy, dermatitis predominantly involving the periorficial areas and extremities, which followed by recurrent attacks of greenish yellow-colored diarrhea, partial and diffuse loss of the scalp hairs, stomatitis and monilial infections, whereas the rest thtee cases seemed to be "forme fruste" of this disease with the absence of hair and nail abnormalities. 3) There found no speeific histologic findings in two biopsies performed but showed somewhat the pictures of sub-acute dermatoses. 4) Candida albicans were demonstrated from the skin lesions in two cases, 5) Treatment with local application of gentian violet solution, nystatin ointment for the skin lesions and stomatitis were temporarily favorable in all cases and in case 1 and 5, diodoquin, each 300mg and 600mg were administered orally in divided doses for two weeks, with the result of satisfactory responses. However, the latter died, on the 3rd hospitalized day, of acute glomerulonephritis and upper respiratory infection. 6) Though it is generally accepted that there is definite familial occurrence in this disorder but we recognized no evidence of familial incidence in our five cases.
Acrodermatitis* ; Aging ; Biopsy ; Busan ; Candida albicans ; Dermatitis ; Dermatology ; Diarrhea ; Extremities ; Gentian Violet ; Glomerulonephritis ; Hair ; Humans ; Incidence ; Iodoquinol ; Nails, Malformed ; Nystatin ; Scalp ; Skin ; Skin Diseases ; Stomatitis

No abstract available.
Herpes Genitalis* ; Herpes Simplex* ; Simplexvirus*

Authors present two casas of familial metaphyseal dysplasia which was first described by Pyle as a skeletal disorder affecting the metaphyseal region of tubular bones. The cases reported here bear some resemblance to that of Bawkin and Krida.

Acute Febrile Neetrophilic Dermatosis(AFND, Sweet's syndrome) ia characterixed by painful erythematous plaquea aaaociatcd with arthralgia, fever and leukocytoeis, We preagented a case of acute febrice neutrophilie denmatoeis in acutemyelogenous leukemia which occurred in a 55-year-old man. After 10 days of treatment with prednisolone, the skin lesion disapceared, but he die of pneumonia in spite of anticancer therapy.
Arthralgia ; Fever ; Humans ; Leukemia ; Leukemia, Myeloid, Acute* ; Middle Aged ; Pneumonia ; Prednisolone ; Skin ; Sweet Syndrome*

Kaposis sarcoma(KS) is a multicentrically developing vascular neoplasm with four types of clinical manifestation. One of these, classic KS is clinically carmcterized by late onset, chronic course and radiosensitive. We report a case of classic KS in a 72-year-old male. This pateint complainted of purple patches and dark purple nxluk. on slightly edematous lower legs. The histopathologic sections from the lesional sites showed infiltration of spindle cells with newly formed vascular slits, dilated blood vessels and aggregated hemosiderins in the dermis.
Aged ; Blood Vessels ; Dermis ; Hemosiderin ; Humans ; Leg ; Male ; Sarcoma* ; Vascular Neoplasms

A 28-year-old male patient is described who developed multiple erythematous nodules and papules on the face, upper chest, back, upper and lower extrimities, leading to extensive ia.filtration of the skin and lymph nodes. Histology from the involved lymph node and skin nodule revealed widely scattered patchy infiltration of abnormal. hyperchromatic polymorphous histiocytes in the dermis. The patient died at about 8 months after onset of the disease, in spite of antineoplastic treatment.
Adult ; Dermis ; Histiocytes ; Humans ; Lymph Nodes ; Lymphoma* ; Male ; Skin ; Thorax

A case of infantile digital fibromatosis which developed on the right fifth toe of 2 year-old girl is reported. Microscopically, the eosinophilic cytoplasmic inclusions were frequently seen in the cytoplasm and outside of the fibroblasts.
Child, Preschool ; Cytoplasm ; Eosinophils ; Female ; Fibroblasts ; Fibroma ; Humans ; Inclusion Bodies ; Toes

Granuloma, annulare is a chronic dermatosis characterized by skin colored, firm intradermal papules or subutaneous nodules, which may be discrete or arranged in an annular configuration. Histologically the dermis shows well define8 areas of necrobiosis of collagen tissue surrounded. by palisading histiocytes and lymphocytes. There may be lobules of epithelioid cells ani multinucleated giant ce.1s surrounding the necrobiotic areas. Many factors have been implicated in the genesis of this reaction. Recent studies have indicated that delayed hypersensitivity reactions rnay be involved in the pathogenesis of granuloma annulare. We present a typical granulorna annulare on a 16 year-old boy who had flesh colored, hyperkeratotic small nodules arranged in ring fashion on the dorsum of hands and right ear auricle.
Adolescent ; Collagen ; Dermis ; Ear Auricle ; Epithelioid Cells ; Granuloma Annulare* ; Granuloma* ; Hand ; Histiocytes ; Humans ; Hypersensitivity, Delayed ; Lymphocytes ; Male ; Necrobiotic Disorders ; Skin ; Skin Diseases

Urticaria is a common disease and a well known reaction pattern of the skin eharacterized by erythema or wheals and edema, that is the results of a local leakage ef plasma, from minute vessels into the connective tissue of the dermis. Seven hundred and sixty cases of urticaria visited to this department from January 1973 to December 1974 were studied clinically in various ways. Patients were classified as acute and chronic urticaria-acute form when the hives have been present for less than 8 weeks and chronic form when the hives lasted longer. In all patients, a detailed history, a complete physical examination, a total and differential leukocyte count, erythrocyte sedimentation rate and routine stool examination were performed. Foods were incriminated as the exciting causes of urticaria by history, diet elimination test and ingestion test. An ice cube test was done for corroboration of cold allergy. Cholinergic urticaria, was diagnosed by the appearance of small wheals surrounded by erythema after exercise, emotional disturbances or hot drinks. The diagnosis of urticaria due to drug was based on the history of urticaria following the taking of a certain drug. Infection as the inciting cause was determined by history and physical examination. The results: 1. The incidence of urticaria is 4. 6% to total number of dermatologic patients. 2. Among the 760 urticaria patients, acute cases were 498 which were 2 times more than chronic cases, and female patients were 474 cases that revealed marked high incidences than male patients. 3. The age of the patients ranged from 2 months to 87 years, and the patients between 20 and 39 years occupied more than half of the all patients. 4. Abnormal hematologic findings were more marked in acute form; leukocytosis and neutrophilia were dominate in acute form, and lymphocytosis and eosinophilia were more marked in chronic form. 5. Among the etiologic factors, the bacterial infection was the most frequent which occupied 22. 4% of the all urticaria patients. 6. Seven cases of urticaria due to parasites were clonorchis sinensis, in which I had experienced the complete recovery with the treatment of subcutaneous injection of clonorchis sinensis antigen (1: 10,000) 0.01- 0.1ml at the interval of one week. 7. In this study, the inciting or perpetuating causes could not be found in 50.8% of patients-46.2% of acute form and 59.5% of chronic form.
Affective Symptoms ; Bacterial Infections ; Blood Sedimentation ; Clonorchis sinensis ; Connective Tissue ; Dermis ; Diagnosis ; Diet ; Eating ; Edema ; Eosinophilia ; Erythema ; Female ; Humans ; Hypersensitivity ; Ice ; Incidence ; Injections, Subcutaneous ; Leukocyte Count ; Leukocytosis ; Lymphocytosis ; Male ; Parasites ; Physical Examination ; Plasma ; Skin ; Urticaria*