No abstract available.

BACKGROUND: Although exact mechanism of adult respiratory distress syndorme (ARDS) is not known, many evidences suggest that inflammatory mediators such as protease and oxygen radicals may be the final common pathway to the endothelial injury. It is gradually accepted that activated neutrophils play a major role in the process. Pentoxifylline is a methylated xanthine with a wide range of actions that make it theoretically useful in the treatment of ARDS. Studies show that it decreases neutrophil phagocytosis and superoxied production. The aim of this experiment is to determine whether pentoxifylline has a preventive effect on oleic acid-induced lung injury. METHODS: Oleic acid (0.08 ml/kg) was infused in 10 mongrel dogs in order to induce acute lung injury. Pentoxifylline (20 mg/kg) was administered 40 mins before oleic acid injection. The author made a comparative studies on the effects of pentoxifylline on hemodynamics and gas exchange before oleic acid injection and at 15, 30, 45, 60, 90 mins after oleic acid injection. RESULTS: There were not significant changes in mean arterial pressure, cardiac output, systemic vascular resistence, pulmonary wedge pressure intrapulmonary shunt in both groups. There were statistical significance in arterial oxygen tension, pulmonary artery pressure, pulmonary vascular resistance between both groups (p<0.05). CONCLUSIONS: Pentoxifylline is a noteworthy drug that could be a candidate as a therapy to help prevent effect in lung injuries that share a common mechanism with oleic acid-induced lung injury.
Acute Lung Injury ; Adult ; Animals ; Arterial Pressure ; Cardiac Output ; Dogs ; Hemodynamics ; Humans ; Lung Injury* ; Lung* ; Neutrophils ; Oleic Acid ; Oxygen ; Pentoxifylline* ; Phagocytosis ; Pulmonary Artery ; Pulmonary Wedge Pressure ; Reactive Oxygen Species ; Vascular Resistance ; Xanthine

Fracuture-dislocation of the cuboid is an extremely rere injury compared with fracture-dislocation of other tarsal bones. We report a case of the fracture-dislocation of the cuboid treated by open reduction and internal fixation.
Tarsal Bones

One hundred and two patients with benign prostatic hyperplasia were treated by transurethral radio-frequency thermotherapy (TURT) device (Thermex-II, Direx, Israel) with 47.5 degrees C in single session for 2 hours and 30 minutes from November 1992 to October 1993. Among them, 83 patients, who were followed up for more than 3 months were included in this study. Twenty-seven (32.5%) patients had a history of acute retention. Pretreated values of the mean Madsen-Iversen symptom score, maximum urine flow rate, postvoiding residual urine volume, prostate volume and prostate specific antigen (PSA) were 15.4, 6.5 ml/sec, 61.3ml, 43.2ml and 0.77 ng/ml respectively. Madsen-Iversen symptom score, maximum urine flow rate were measured at 2 weeks, 1, 3 and 6 months after TURT. The residual urine volume, prostate volume and PSA level were measured at 3 and 6 months after TURT. During the follow up, the symptom score started to decrease significantly at 1 month (9.9, p< 0.01) after TURT, and gradually decreased up to 6.9 at 3 months. The maximum flow rate showed initial significant improvement at 2 weeks (8.1 ml/sec., p< 0.01), but no significant interval change was observed thereafter. The residual volume decreased significantly at 3 months (41.3 ml, p< 0.01) and no decrement was noted until 6 months. Neither the prostate volume nor PSA value changed significantly at 3 or 6 months after TURT. The improvement, which was defined as a change of 50% or more in at least one of subjective or objective symptoms showed in 63.9% (53/83) at 3 months and 57.1% (32/56) at 6 months. Both subjective and objective improvements at 3 and 6 months after treatment showed in 24.1% and 19.6%, respectively.
Aged ; Follow-Up Studies ; Human ; *Hyperthermia, Induced/methods ; Male ; Middle Age ; Prognosis ; Prostatic Hyperplasia/*therapy ; Radio Waves/therapeutic use

A clinical observation was made on 284 cases of renal diseases, admitted to the Department of Urology, National Medical Center from January 1972 to December 1971 The results were as follows ; 1) During this period, the total number of in-patients were 969 among which patients with renal diseases were 284 (29.3 %). And ratio between male and female patients was 1.2:1 2) Among renal diseases, the patients with tbc or stone were occupied over half (62.6 %). 3) In renal tbc, the prevalence rate of complication became decreased due to early treatment by early visiting to hospital. And patients taken with only anti-Tb medication became increased. 4) In renal stone or renal injury, there was tendency of taking conservative treatment(pyelolithotomy etc.) rather than taking surgical intervention as like nephrectomy etc.
Female ; Humans ; Male ; Nephrectomy ; Prevalence ; Urology

PURPOSE: Methylphenidate is the most widely used central nervous system stimulant in patients with attention deficit hyperactivity disorder. However, few studies have assessed its effects on voiding. Various doses of methylphenidate were investigated for their effects on cystometric parameters in conscious mice. METHODS: Ten male C57BL/6 mice, weighing between 20 and 23 g, were used in this study. To compare the acute drug responses before and after the oral medication was administered in the awake condition, we injected the solution through a catheter inserted into the stomach. Methylphenidate (1.25, 2.5, and 5 mg/kg) in an injection volume of 0.05 mL was administered. RESULTS: Four mice that received high doses of methylphenidate (2.5 and 5 mg/kg) showed no voiding contraction, with urine leakage. Six mice that received a low dose of methylphenidate (1.25 mg/kg) showed typical micturition cycles before and after administration. The micturition pressure decreased and bladder capacity increased without an increased residual volume after administration. CONCLUSIONS: Methylphenidate has differential, dose-dependent effects on the function of the lower urinary tract, due to the dependent relationship between the brain and lower urinary tract. Especially at higher doses, this drug may interfere with normal micturition. Therefore, more detailed clinical or experimental studies are warranted in the future.
Animals ; Attention Deficit Disorder with Hyperactivity ; Brain ; Catheters ; Central Nervous System ; Humans ; Male ; Methylphenidate* ; Mice ; Residual Volume ; Stomach ; Urinary Bladder ; Urinary Bladder, Neurogenic ; Urinary Tract ; Urination ; Urodynamics

No abstract available.
Apolipoproteins* ; Genotype* ; Humans ; Myocardial Infarction*

A hypoplastic empty scrotum is a critical factor in the success of implantation of artificial testis. A hypoplastic scrotum increases the postoperative complication, such as wound dehiscence and prosthesis extrusion. Any technique cannot overcome this problem satisfactorily. Furthermore previous operative scars and inflammatory disease as epididymo-orchitis have often added to the difficulties. Enlarging the scrotum by gradual distention of a tissue expander implanted in the contracted scrotum has been successful in overcoming this problem. We report a case of successful artificial testes implantation after gradually enlarging scrotum by tissue expander in a 6 year old boy, who was diagnosed anorchidism with scrotal hypoplasia.
Child ; Cicatrix ; Humans ; Male ; Postoperative Complications ; Prostheses and Implants ; Scrotum ; Testis* ; Tissue Expansion Devices* ; Wounds and Injuries

To our knowledge, there are no reported cases of rectal fistula complicating spondylodiscitis. We report the first case of a rectal fistula communicating with the site of postoperative recurrent spondylodiscitis. A-59-year-old female had recurrent spondylodiscitis after an open discectomy for L5-S1 eight years earlier. She underwent three operations including two anterior lumbar interbody fusion procedures after an open discectomy. Radiographic studies revealed severe bony destruction with abscess collection within the L5-S1 intervertebral disc space with fistula formation into the rectum. The fistula was confirmed by a Barium enema colon study and sigmoidscopy. The patient underwent a staged operation consisting of a rectosigmoid colon resection, anterior interbody fusion and posterior instrumented fusion. Rectum related complications were suspected in this case of recurrent spondylodiscitis.
Abscess ; Barium ; Colon ; Discitis ; Diskectomy ; Enema ; Female ; Fistula ; Humans ; Intervertebral Disc ; Rectal Fistula ; Rectum

Management of the impalpable testis is one of the controversial issues in cryptorchidism. So we studied to evaluate the usefulness of laparoscopy and surgical methods for impalpable testis. From January 1992 to December 1993, a total of 36 patients with impalpable cryptorchid was admitted to Seoul National University Children's Hospital. All the patients were examined by laparoscopy under general anesthesia. According to laparoscopic finding, in 15 patients with high abdominal testis, we performed 5 microscopic testicular autotransplantations and 10 testicular vessels transsections(Fowler-Stephens method). In other cases, We performed 9 standard orchiopexies and 6 orchiectomies. Complication of laparoscopy was not experienced. During mean follow up period of 12 months, success rate was 80% in microscopic testicular autotransplantation, 80% in testicular vessels transsection and 91% in standard orchiopexy. Therefore, we think that laparoscopy can be used safely to assess the accurate location of impalpable testis and that surgical methods including testicular autotransplantation are acceptable to high abdominal testis.
Anesthesia, General ; Autografts ; Cryptorchidism ; Follow-Up Studies ; Humans ; Laparoscopy ; Male ; Orchiectomy ; Orchiopexy ; Seoul ; Testis*