1.Intra-abdominal Angiosarcomatosis Induced by Irradiation.
Hee Jin CHANG ; Youn Joo KIM ; Sung Eun YANG ; Sung Sook PAENG ; Jung Il SUH
Korean Journal of Pathology 1997;31(3):269-274
Therapeutic irradiation can induce angiosarcoma. Radiation-induced angiosarcoma constitutes 20% of all angiosarcomas. Although its common site of origin is the skin and subcutaneous tissue, it rarely arises in small or large bowels with a presentation as multifocal abdominal angiosarcomatosis. We report a case of intra-abdominal angiosarcomatosis involving the jejunum, ileum, transverse colon, mesentery and right ovary in a 63-year-old female. It developed 10 years after therapeutic irradiation for squamous cell carcinoma of uterine cervix. She developed panperitonitis due to intestinal perforation. She died from sepsis 3 days after segmental resection of the small bowel and right oophorectomy. We reviewed the previously reported cases and describe the clinicopathologic features of this tumor.
Carcinoma, Squamous Cell
;
Cervix Uteri
;
Colon, Transverse
;
Female
;
Hemangiosarcoma
;
Humans
;
Ileum
;
Intestinal Perforation
;
Jejunum
;
Mesentery
;
Middle Aged
;
Ovariectomy
;
Ovary
;
Sepsis
;
Skin
;
Subcutaneous Tissue
2.Bronchus-Associated Lymphoid Tissue Lymphoma.
Yoon Ju KIM ; Sung Sook PAENG ; Hee Jin CHANG ; Jung Il SUH
Korean Journal of Pathology 1998;32(11):1035-1038
Malignant lymphoma arising from mucosa-associated lymphoid tissue (MALT) represents distinct clinicopathologic features and remains localized for prolonged periods. We report a case of low grade B cell lymphoma of bronchus-associated lymphoid tissue (BALT). A 60-year-old female had a long-standing cough, sputum and intermittent fever for 10 years. In 1984, the chest radiography showed increased hazy density in both upper lungs. Although she had been treated by antituberculous medication under clinical diagnosis, there was no improvement. In 1995, open lung biopsy was carried out. Histologically, it showed massive nodular or diffuse infiltration of centrocyte-like cells in bronchus and parenchyme with pleural invasion. On immunohistochemical stain, they were positive for LN-2 and L26 and negative for UCHL-1, LN-1 and LN-3. In polymerase chain reaction (PCR), Ig heavy chain gene rearrangement was detected. The patient was well for 6 months after the biopsy.
Biopsy
;
Bronchi
;
Cough
;
Diagnosis
;
Female
;
Fever
;
Gene Rearrangement
;
Humans
;
Lung
;
Lymphoid Tissue*
;
Lymphoma*
;
Lymphoma, B-Cell
;
Middle Aged
;
Polymerase Chain Reaction
;
Radiography
;
Sputum
;
Thorax
3.Cytologic and Histologic Findings of Acinic Cell Carcinoma of the Salivary Gland Related to Malignant Behavior: 2 Cases Report.
Sung Suk PAENG ; Hee Jin CHANG ; Jung Il SUH ; Hyo Sook PARK
Korean Journal of Cytopathology 1997;8(1):62-68
Acinic cell carcinoma is a slow-growing solid neoplasm of salivary gland. Although their cytological and histological finding is bland-looking, their biological behavior is unpredictable. We experienced two cases of acinic cell carcinoma of the salivary gland diagnosed by fine needle aspiration biopsy and confirmed by tissue examination. They showed different clinical courses. We compared their cytologic and histologic findings. The first case was a right preauricular mass in a 58 year-old female of 3 years duration. The cytologic smear revealed sheets or small clusters of monotonous cells mimicking normal serous acinar cells with little cellular pleomorphism. She underwent superficial parotid lobectomy. The tumor was a well demarcated 1.5cm sized nodular mass without infiltration into surrounding parenchyme. The second case was a left submandibular mass in a 23 year-old male of 4 years duration. The smear showed more severe pleomorphism of the tumor cells than those of previous case. Excisional biopsy was done. The excised tumor was 5.5*3.5*3cm sized multilobulated solid mass with invasion into surrounding parenchyme. The tumor recurred after 20months, thus total excision of the mass and modified radical neck dissection was carried out. From the above findings, cytologic atypism, infiltrative growth pattern and type of initial therapy may be correlated with biologic behavior.
Acinar Cells*
;
Biopsy
;
Biopsy, Fine-Needle
;
Carcinoma, Acinar Cell*
;
Female
;
Humans
;
Male
;
Middle Aged
;
Neck Dissection
;
Salivary Glands*
;
Young Adult
4.Cytologic Findings of Breast Carcinoma in Fine Needle Aspiration: Comparison with Histologic Findings, Stage and Lymph Node Metastasis.
Hee Jin CHANG ; Duck Hwan KIM ; Sung Sook PAENG ; Sung Eun YANG ; Jin Hee SOHN ; Jung Il SUH ; Hyo Sook PARK
Korean Journal of Cytopathology 1995;6(1):18-26
In order compare cytologic findings of breast carcinoma in fine needle aspiration cytology (FANC) with histologic findings and prognostic factors including histologic grading, lymph node metastasis and stage, 79 cases of infiltrating ductal carcinoma diagnosed by FANC and confirmed by histology were analysed. We especially attempted to correlate nuclear grade, cellularity and smear pattern with histologic grade, type, status of lymph node metastasis and stage. The results are as follwos : 2. Individual cell pattern was more frequently identified in high histologic grade and scirrhous or solid-tubular type than in low histolgic grade and papillotubular type. 3. Cellularity increased with higher histologic grade and lymph node metastsis. However cellularity was low in scirrhous type. 4. There is no relationship between nuclear grade and histologic type, between smear pattern and lymph node metastasis or stage, and between cellularity and stage. These results suggest that cytologic findings of breast carcinoma such as nuclear grade, cellularity and smear pattern are indicative of histologic findings in relation to histolgic grade and type. Especially, nuclear grade of FANC may yield valuable prognostic information.
Biopsy, Fine-Needle*
;
Breast Neoplasms*
;
Breast*
;
Carcinoma, Ductal
;
Lymph Nodes*
;
Neoplasm Metastasis*
5.Immunohistochemical Study of p53 and nm23-H1 Protein in Gastric Carcinoma.
Duck Hwan KIM ; Yoen Ju KIM ; Seon Eun YANG ; Sung Suk PAENG ; Hee Jin CHANG ; Jung Il SUH ; Hyo Sook PARK
Korean Journal of Pathology 1996;30(7):587-594
The p53 gene, which resides on the short arm of chromosome 17, has been described as a tumor suppressor gene playing a role of G1 checkpoint monitering DNA damage, but mutation of this gene has been shown in numerous types of human cancers. The nm23-H1 gene encodes human NDP(nucleotide diphosphate) kinase. The expression of nm23-H1 gene was postulated to inversely correlate with metastatic potential of malignant tumors. We examined immunohistochemical expression in 30 cases of stomach cancers including 10 cases each of early gastric cancers(EGC), advanced gastric cancers without lymph node involvement, and advanced gastric cancers with lymph node involvement, which were stained with mouse monoclonal antibody of p53(PB53-12) and nm23-H1. Positive nuclear staining of p53 was frequently found in advanced gastric cancers with lymph node involvement (80%). The lymph node positive group showed high expression of p53(80%), and low expression of nm23-Hl(30%) than lymph node negative group. There was no significant correlation of p53 and nm23-H1 expression with tumor size, invasion depth, TNM stages, distant metastasis and histologic differentiation. Based on the present study, the expression of p53 and down regulation of nm23-H1 are thought to be correlated with tumor progression and lymph node involvement, and may be a useful prognostic factor in gastric cancers.
Humans
;
Mice
;
Animals
;
Neoplasm Metastasis
;
Genes, Tumor Suppressor
;
Stomach Neoplasms
;
Genes, p53
6.Prevalence of subclinical hypothyroidism in hypercholesterolemic adults and influence of serum TSH on the serum total cholesterol level.
Won Jea JEONG ; Young Seol KIM ; Byeong Heon PARK ; Cheol Young PARK ; Mee Sook RYU ; Seung Joon OH ; Jeong Tack WOO ; Sung Woon KIM ; In Myoung YANG ; Jin Woo KIM ; Young Kil CHOI ; Jeong Ryung PAENG
Korean Journal of Medicine 2002;62(2):187-193
BACKGROUND: Subclinical hypothyroidism is frequently discovered from hypercholesterolemic adults. It is defined as an asymptomatic state which characterized by normal free thyroxine (FT4) and elevated thyroid stimulating hormone (TSH) level. Hypercholesterolemia is a major risk factor for coronary heart disease, however hypercholesterolemia caused by hypothyroidism can be easily managed by thyroid hormone replacement. The screening of thyroid disease in hypercholesterolemia patient must be emphasized in order to find out correctable hypothyroidism. So we screened the prevalence of overt and subclinical hypothyroidism at different hypercholesterol levels in middle-aged men and women and also analyzed the correlation between TSH and total cholesterol level. METHODS: We measured serum TSH levels and FT4 by radioimmunoassay from 491 patients with hypercholesterolemia. The subjects were divided into two groups according to serum cholesterol level. Group I was serum cholesterol > or = 240 -<300 mg/dL and group II was > or = 300 mg/dL. Subclinical hypothyroidism was defined as TSH levels higher than 4 mU/L, in the presence of normal FT4 concentration. RESULTS: The overall prevalence of subclinical and overt hypothyroidism was 3.4% and 2.5% in men and 4.7% and 3.5% in women of middle age. In men the prevalence of overt and subclinical hypothyroidism increased from 2.3% of group I to 16.1% in the group II (p<0.05). In women that increased from 5.2 % to 12.9 % (p<0.05). After age correction, an increase of 1 mU/L TSH in men was associated with an increase of 3.2 mg/dL total cholesterol (p<0.01). A similar trend was also found in women (2.1 mg/dL p=0.052). CONCLUSION: In this population, the prevalence of hypothyroidism is up to 16.1% in middle-aged men, 12.9% in middle-aged women with high total cholesterol and it may justify screening of thyroid disease in hypercholesterolemic patients especially in clinical practice.
Adult*
;
Asymptomatic Diseases
;
Cholesterol*
;
Coronary Disease
;
Female
;
Humans
;
Hypercholesterolemia
;
Hypothyroidism*
;
Male
;
Mass Screening
;
Middle Aged
;
Prevalence*
;
Radioimmunoassay
;
Risk Factors
;
Thyroid Diseases
;
Thyroid Gland
;
Thyrotropin
;
Thyroxine