No abstract available.
Child* ; Humans

No abstract available.
Fosinopril* ; Humans ; Hypertension*

No abstract available.

No abstract available.
C-Reactive Protein* ; Chorioamnionitis* ; Female ; Humans ; Membranes* ; Pregnancy ; Rupture*

No abstract available.
Myocutaneous Flap* ; Pressure Ulcer*

OBJECTIVE : To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in recurrent spontaneous abortion associated with hyperhomocysteinemia. MATERIAL AND METHOD: The blood Sample of habitual aborter with high fasting homocysteine level was tested by PCR-RFLP method. RESULTS: The patient was found to be a homozygosity for MTHFR gene mutation that was confirmed by the finding which is consistent with the mutation at the nucleotide 677 C to T, Corresponding to Ala to Val. CONCLUSIONS: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the MTHFR mutation should be examined in the workup of recurrent spontaneous abortion showing hyperhomocysteinemia.
Abortion, Spontaneous* ; Fasting ; Female ; Homocysteine ; Humans ; Hyperhomocysteinemia* ; Methylenetetrahydrofolate Reductase (NADPH2)* ; Pregnancy

OBJECTIVE: The purpose of this study was to evaluate the therapeutic efficacy and toxicity of high dose cisplatin-cyclophosphamide combination chemotherapy on patients with primary epithelial ovarian cancer. METHODS: A review of 63 patients previously diagnosed as primary epithelial ovarian cancer after initial operation and histology at Pusan National University Hospital from Jul. 1993 to Jun, 1997 was performed. Patients were received the combination chemotherapy including cisplatin 100mg/m2/day and cyclophosphamide 750mg/m2/day, repeated 6 cycles every 4 weeks. The mean age was 48 years old, and previous surgical procedures were total abdominal hysterectomy and bilateral salpingo-oophorectomy with omentectomy. The patients were classified into FIGO stage and pathologic results. RESULTS: The clinical response rate was 100% in the FIGO stage Ic patients with PC combination chemotherapy, 100% in stage II, 53.5% in stage III, and 25% in stage IV. The overall response rate was 69.8%. The 3-year survival rate according to the treatment groups was 93.3% in stage Ic group, 60% in stage II, 50% in stage III and 0% in stage IV. The mean survival duration was 34.6 months. Hematologic toxicities in cisplatin-cyclophosphamide chemotherapy were neutropenia and anemia. Nausea and vomiting were the most common side effects and occurred in 96.8%. Most of the toxicities were grade 1 and 2. CONCLUSION: The combination chemotherapy with cisplatin-cyclophosphamide is relatively safe and effective method in the treatment of primary epithelial ovarian cancer.
Anemia ; Busan ; Cisplatin* ; Cyclophosphamide* ; Drug Therapy ; Drug Therapy, Combination* ; Humans ; Hysterectomy ; Middle Aged ; Nausea ; Neutropenia ; Ovarian Neoplasms* ; Survival Rate ; Vomiting

No abstract available.
Pressure Ulcer*

To elucidate the argument on the hypertensive effect of repeated stress, morphological study on the juxtaglomerular apparatus of pain-stressed mice was carried out. Following the repeated stress on mice by subcutaneous injections of formalin every day, animals were sacrificed on 1, 3, 6, 12 hours and 1, 2, 3, 6 days after the 5th injection. Kidneys fixed in 10%, Zenker-formol solution were routinely processed, and 4um sections were stained by Bowie's stain. For the precise interpretation, following protocols were applied; Comparing the amount of secretory granules, juxtaglomerular granulation index (JGI) was weighted on every 1000 glomeruli according to their granulaities. Comparing the proportional appearance of juxtaglomerular apparatus, granulation cell index (GCI) was counted as a mean number of granular juxtaglomerular apparatus among every 100 glomeruli. Comparing the cellularities of a single juxtaglomerular apparatus, juxtaglomerular granular cell count (JGCC) was counted as a mean number of granular juxtaglomerular cells appearing in a longitudinally. sectioned afferent arteriole. Comparing the functional relationship between the juxtaglomerular cells and macula densa cells, macula densa cell count (MD count) was counted as the mean number of macular densa cells having contacts with granular juxtaglomerular cells. Result of this experiment was processed and interpreted as followings. 1. Repeated pain-stress give rise to the prominant effect to juxtaglomerular cells, as high as double granular amount as compared to normal one, during 3-6 hours after the last stress. 2. Functional relationship between the distal convoluted tubule and Juxtaglomerular cells, checked out by MD contacts, was also highest during 3 to 6 hours term. 3. The effects were decreased afterwards, but still most counts were higher than those of normal data until 6th day, the last term of this experiment. 4. Present study show that the repeated pain-stress initiate the significant pressure-rising effect to animals during the first day after the last stress, and these effects may be latent during some days afterwards. 5. As the precise mechanism involved in this aspect remains to be elucidated, further studies includingelectron microscopic and histochemical methods shall be suggested.
Animals ; Arterioles ; Cell Count ; Formaldehyde ; Injections, Subcutaneous ; Juxtaglomerular Apparatus ; Kidney ; Mice* ; Secretory Vesicles

PURPOSE: The purpose of the study was to examine the relationships among social support (network, composition, and satisfaction), stress, and loneliness in migrant Yanbian Korean workers. METHOD: Data were collected by using Social Support Questionnaire 6, Visual Analogue Scale, and the Revised UCLA Loneliness Scale. RESULT: Results indicate that means for social support were 1.52 for network size and 4.83 for satisfaction. The proportion percentage of network for kin members was 67.37. Subjects felt the moderate level of stress and loneliness. The level of loneliness was negatively related to the level of social support. CONCLUSION: This study showed that there is necessity to reduce stress and loneliness among migrant Yanbian Korean workers. Adequate social support satisfaction is crucial to reduce the level of loneliness in migrant Yanbian Korean workers.
Humans ; Loneliness* ; Transients and Migrants*