No abstract available.
Fever*

No abstract available.
Fever*

No abstract available.
Gene Expression*

Hepatits B virus[HBV] is a world wide-pathogen that causes hepatitis. Infection with HBV may be chronic and is associated with subsequent development of hepatocellular carcinoma. In korea the prevalence rate of B hepatitis is estimated to be 7-10%. Despite the severiority of B hepatitis its pathogenesis, chronicity mechanism, prevention and treatment mode have not been developed. The most vexing technical problem in the biology of HBV has been lack of a practical in vitro system that allows infection and replication of this virus under controlled experimental condition. This study was carried out to develop in vitro model of HBV using liver organ culture system. Infection was carried out co-cultivation of 260 micrometer thick-rat liver slices with HBV obtaind from liver biopsy of patient with HBs antigenemia. Aliquots of culture medium were taken in at 6 hour intervals. Hepatitis surface antigen of culture medium in 12 hour incubation increased ab about two folds in comparing with 6 hour incubation. Dot blot analysis of extrachromosomal HBV DNA in cultured rat liver slices using whole HBV DNA as a probe. Fold increment of viral DNA after 12 hours incubation versus 6 hours was measured as 1.7-fold. The presence of viral antigens and Dane particles were observed with immunohistochemical and electron microscopic techniques. In coclusion I present evidece of development for in vitro model of HBV using organ culture system. This system will be useful for understanding the pathogenesis.
Animals ; Antigens, Surface ; Antigens, Viral ; Biology ; Biopsy ; Carcinoma, Hepatocellular ; DNA ; DNA, Viral ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans* ; Korea ; Liver ; Organ Culture Techniques ; Prevalence ; Rats

No abstract available in English.
Fatigue ; Fractures, Stress

The main objectives of this study were to know the prevalence of cerebrovascular disease, to find the important risk factors of cerebrovascular diseases. This study is a part of Eumseong Community Health Project supportes by GTZ(West German Government). 116 perceived cases of cerebrovascular disease were first screened by health interview and examinations and 80 cases were diagnosed as a cerebrovascular group. For comparison, 80 cases were matched with their neighbor controls of the same sex and the similar age. 1. The prevalence rate for cerebrovascular diseases was 476.3 per 100,000 population which is considered to be very high compared with that of other countries. Age adjusted rate for cerebrovascular diseases was 261.6 per 100,000. 2. Among the risk factors examined for the association with cerebrovascular diseases by case-control study, and analyzed by paired marginal test(McNemar's chi-square-test) and odds ratio, only hypertension showed high significant statistical association.
Case-Control Studies* ; Hypertension ; Odds Ratio ; Prevalence ; Risk Factors* ; Rural Population*

No abstract available.
Autografts*

No abstract available.
Gastrectomy*

No abstract available.
Dermatitis, Contact*

No abstract available.