Thrombosis of one or both renal veins occurs in a variety of settings such as trauma, dehydration, extrinsic compression, nephrotic syndrome, pregnancy, oral contraceptives or invasion by tumor. Nephrotic syndrome and certain carcinomas seem to predispose to the development of renal vein thrombosis. The most common carcinoma which is associated with renal vein thrombosis is the renal cell carcinoma. But, renal vein thrombosis associated with tumor other than renal cell carcinoma is extremely rare. Our patient was diagnosed as lung and uterine cervical cancer by histologic examination. The patient complained of left flank pain. Abdominal CT scan shows the dilated left renal vein filled with hypodense material and parenchymal infarction on the left kidney. Renal arteriography shows cut-off sign on a branch of the left renal artery. Inferior venacavography revealed contrast-filling defect in the left renal vein. To our knowledge, renal vein thrombosis with lung and uterine cervical carcinoma is the first report in English literature. So, we have presented a rare case of a renal vein thrombosis in a patient with lung and uterine cervical cancer.
Angiography ; Carcinoma, Renal Cell ; Contraceptives, Oral ; Dehydration ; Flank Pain ; Humans ; Infarction ; Kidney ; Lung Neoplasms ; Lung* ; Nephrotic Syndrome ; Pregnancy ; Renal Artery ; Renal Veins* ; Thrombosis* ; Tomography, X-Ray Computed ; Uterine Cervical Neoplasms*

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

No abstract available.
Blepharoptosis*

This study was performed to evaluate the clinical significance of SCC as a tumor marker in patient with squamous cell carcinoma of the cervix. We measured the serum levels of SCC by radioimmunoassay in patient with invasive squamous cell carcinoma of cervix to determine the prognostic value, correlation with the presence of lymph node metastasis, response to treatment, and those value in the early detection of recurrence after treatment. The result was: 1) In 117 of 174 patients with cervical cancer, the pretreatment positive rate of SCC was 47.0%(57/117). In each stage, the stage Ia was 25.0%, Ib 26.3%, IIa 56.0%, 62.6%, III 57.1%, IV 100%, and the recurrent case was 37.5%. 2) In 79 of 174 patients with cervical cancer, the pretreatment positive rate of SCC was 44,0%(30/69) in no evidence of malignancy patients, but 60.0%(6/10) in recurrent or permanent patients(p>0.05), 3) In 133 of 174 patients with cervical cancer, the posttreatment positive rate of SCC was 2.6%(3/117) in no evidence of malignancy patients, but 50.0%(8/16) in recurrent or permanent patients(p<0.05). 4) In 48 patients of 174 with cervical cancer who underwent radical hystrectomy, the positive rate of SCC was 71.4%(5/7) in pelvic lymph node positive patients but 19,5%(8/41) in pelvic lymph node negative patients(p<0.05). We concluded that the pretreatment SCC level was not effective as a prognostic value, but well correlated with pelvic lymph node metastasis, and serial measurements of serum levels of SCC provided a reliable clue for early detection of recurrence or progression of disease, so it may be useful for monitoring cervical carcinoma patient.
Carcinoma, Squamous Cell* ; Cervix Uteri* ; Female ; Humans ; Lymph Nodes ; Neoplasm Metastasis ; Radioimmunoassay ; Recurrence ; Uterine Cervical Neoplasms

Subluxation of hip is a disease commonly experienced in orthopaedic field, which is classified into primary subluxation and secondary subluxation. Generally, secondary subluxation of the hip in children who once suffered from infected hips, Legg-Calve-Perths disease and also as sequellae of incompletely treated congenital dislocation of the hip can be often seen in Korea. Especially in Korea, subluxation of the hip with some destruction of the affected femoral head frequently arose from late complication of the tuberculous or septic hip in children. But, no definite treatment for the condition was established and no satisfactory results were obtained with various operative methods. Authors experienced satisfactory result by combining the intertrochanteric varus osteotomy and administration of crystalline glucosamine sulphate (Viatril, Rotta pharmaceuticals, Italy) in subluxated burnt-out tuberculous hip of 6 years old male.
Child ; Crystallins ; Dislocations ; Glucosamine ; Head ; Hip ; Humans ; Korea ; Male ; Osteotomy ; Tuberculosis

The human trachea is normally lined by a pseudostratified ciliated columnar epithelium where ciliated, goblet, intermediate and basal cells are mainly represented. However the fetal tracheal epithelium was found to be composed of ciliated, non-ciliated and basal cells. The present study was designed to characterize the development of ciliated cells in the fetal trachea at mid (19 weeks) and last (32 weeks) trimester of gestation. At 19 weeks of gestation, the tracheal epithelium, 35 µm in height, was composed of surface, intermediate and basal layers. The surface cells were subdivided into ciliated, immature ciliated, non-ciliated, granule containing and goblet cells. The ciliated cells covered approximately half of the luminal surface area. The immature ciliated cells contained basal bodies, but the apical membrane was not invested with cilia. The granule containing cells contained numerous dense granules, 0.3-0.7 µm in diameter, in the apical cytoplasm. The goblet cells contained less electron dense granules, 1-2 µm in diameter, in the apical cytoplasm. The cells in intermediate layer were relatively undifferentiated and contained poorly developed organelles. Submucosal gland were well differentiated and were composed of the mucous and serous cells. At 32 weeks of gestation, the tracheal epithelium, 50µm in height, was also composed of surface, intermediate and basal layer. The surface cells were composed of ciliated, non-ciliated and goblet cells. The ciliated cells, dominant type of surface cells, were subdivided into mitochondria-rich cells (type I) and smooth endoplasmic reticulum-rich cells (type II). The non-ciliated cell were of three subtypes : mitochondria-rich cells (type A), glycogen and microfilament-containing cells (type B) and cells with bulging apical surface into the lumen (type C). Small granule containing cell appeared in the basal layer. These cells contained clear vesicles, 50 ㎚m in diameter, and dense granules, 100-300 ㎚m in diameter. Submucosal gland were well developed and consisting of mucous, serous and myoepithelial cells. These results indicate that the cell populations of the tracheal epithelium at late stage of pregnancy have essential features similar to those of adult. and show that the different steps of ciliogenesis could be identified.
Adult ; Basal Bodies ; Cilia ; Cytoplasm ; Epithelium* ; Fetus* ; Glycogen ; Goblet Cells ; Humans* ; Membranes ; Organelles ; Phenobarbital ; Pregnancy ; Trachea

Multiple involvement of arterial fibromuscular dysplasia is unusal and such a case is quite limited in the literature. We present a case of multiple arterial fibromuscular dysplasia with aneurysm formation in a 38-year-old non-hypertensive man. Angiographic study showed multiple aneurysmal dilatations of the right renal, superior mesenteric, celiac axis, and left colic arteries. The resected right kidney demonstrated an aneurysm of the main renal artery and extensive infarction in the midportion of the renal parenchyma. The segmentally resected superior mesenteric artery disclosed a similar nature of aneurysm occluded by recent thrombi. Microscopically, all the resected arterial walls showed both intimal and medial fibroplasia together with periadventitial fibrosis resulting in marked narrowing of the lumen and subsequent thrombus formation.

Interleukin-6 (IL-6) is introduced as a marker of disease. At present, a variety of method may be used to quantify expression of this protein. Antigen capture-ELISA is a sensitive and accurate quantification method previously used with ovine, rat, and human IL-6 proteins. However, it has never been reported to quantify porcine IL-6 protein using capture ELISA. In this study, we generated and characterized a set of IgY and mono-specific polyclonal antibodies to recombinant porcine IL-6 (rpIL-6), and combining these with a sensitive and specific capture-ELISA for a diagnostic purpose. cDNA encoding the mature protein coding region of porcine IL-6 was cloned and expressed with pQE-30UA expression vector. rpIL-6 was then expressed and purified by using Ni-NTA resin. Protein mass of 24 kDa was found with SDS-PAGE and the identity of the protein was confirmed by Western-blot. Production of polyclonal antibodies against rpIL-6 was performed using the purified rpIL-6 in mice and hens. An antigen capture-ELISA was developed with the antibodies after their extraction. To compare the IL-6 level in the different sanitary state of farms, pig sera were randomly collected and concentration of IL-6 in the sera was measured with the antigen capture-ELISA. The capture-ELISA with the optimal concentration of antibodies, in this study, was able to detect about 10 ng/ml of rpIL-6. IL-6 levels determined with the capture-ELISA in pig sera showed positive correlation with the sanitary states of the farms. These results suggested that the developed antigen capture-ELISA could be a good tool for the screening of microbial infection in pig farms.
Animals ; Biological Markers/blood ; Blotting, Western/veterinary ; Chickens ; Cloning, Molecular ; DNA, Complementary/genetics/isolation&purification ; Electrophoresis, Polyacrylamide Gel/veterinary ; Enzyme-Linked Immunosorbent Assay/methods/*veterinary ; Female ; Immunoglobulins/*blood ; Interleukin-6/*immunology ; Mice ; Mice, Inbred ICR ; Recombinant Proteins/immunology ; Swine/*immunology

Experiment of electrical stimulation using direct current on the tibia of normal adult rabbits was performed for the duration of 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks, and 8 weeks. The cathodic electrode, Teflon coated Kirschner wire used in clinical work was introduced into the medullary cavity of the proximal tibia from the tibial tuberosity and the anodic electrode was introduced transversely in the metaphysis of distal tibia on the same side. Twenty micro-ampere of direct current was passed continuously through the fixed wires between the proximal and distal tibia on left side. At the end of first week, second week, third week, fourth, sixth, and eighth week, anodic and cathodic electrode were removed and animals were sacrificed and tibia was obtained for specimen, and then X-rays were taken, and the specimens were decalcified and stained with hematoxylin and eosin. The new bone formation in the medullary canal were measured by the degree of filling in the marrow canal as percentage by the point counting method. The results were as follows. First, Endosteal new bone formation is a main feature, and also periosteal reaction was noted in 27 % of cases. Second, In the first week group, new bone formation is minimal and difference between groups, that is, second, third, fourth, sixth and eight week group, the degree of new bone formation is statistically insignificant. Therefore possibility of short term electrical stimulation of duration of two week or four week is contemplated clinically.
Adult ; Animals ; Bone Marrow ; Electric Stimulation ; Electrodes ; Eosine Yellowish-(YS) ; Hematoxylin ; Humans ; Methods ; Osteogenesis ; Polytetrafluoroethylene ; Rabbits ; Tibia