The experimental study for extracorporeal preservation of the autoperfused working heart-lung preparation was performed in 5 dogs. Their weights were between 14??6kg, average of 14.8kg. The preparations were observed from 6 to 8 hours under autoperfusion, average of 5.2 hours. Hemodynamic and hematologic variables were measured during preharvest and autoperfusion. The experimental results during the autoperfusion were as follow : The arterial blood pH revealed severe respiratory alkalosis due to very low PaCO2. PaO2, 130~150mmHg remained constant; Heart rates remained constant at 110/min and the mean aortic pressures were maintained at 75mmHg; Serum Na and Ca showed mild decrease and serum K, moderate increase; Hemoglobulin and white cell count decreased progressively. The lung showed grossly focal congestion and atelectasis following 3~4 hours of autoperfusion and both findings worsened progressively, and little abnormality appeared in the heart. According to the light microscopic findings in the lung, congestion increased 3~4hours following autoperfusion and worsened between the 6th and 8th hours of autoperfusion. Atelectasis, inflammatory infiltration, edema, and hemorrhage worsened after the 4th hour. Emphysematous changes were initially severe to decreasel later on. Hyaline membrane developed after 6 to 8 hours. Hyaline thrombi appeared after 2 hours. The heart was examined by and electron microscope. Vacuolization increased mildly at the 6th to 7th hour. Mitochondrial swelling and cellular swelling showed focally near the end of the perfusion. Glycogen amount was rich throughout the perfusion. It was concluded that the heart preservation was good but the preparation of the lung seemed to be inadequate after 3~4 hours by this autoperfusion technique.
Alkalosis, Respiratory ; Animals ; Arterial Pressure ; Cell Count ; Dogs ; Edema ; Estrogens, Conjugated (USP) ; Glycogen ; Heart ; Heart Rate ; Hemodynamics ; Hemorrhage ; Hyalin ; Hydrogen-Ion Concentration ; Lung ; Membranes ; Mitochondrial Swelling ; Perfusion ; Pulmonary Atelectasis ; Weights and Measures

No abstract available.
Pulmonary Atresia* ; Ventricular Septum*

No abstract available.
Aortic Aneurysm*

No abstract available.
Actinomycosis* ; Lung*

The study consisted of all patients over 35yerars old undergoing surgical repair of atrial septal defect for the period from June 1985, to August 1992. The following results were observed. 1. ASD was closed with patch in 11 (73%) patients. 2. The relationship of pulmonary artery systolic pressure to Qp/Qs ratio was not significant. 3. Before operation 6 patients were in NYHA functional class II. 8 were in class III, After operation 8 patients were in class I, 6 were in class II. 4. Atrial fibrillation has persisted in 3 patients and returned regular rhythm in 1 patient after surgery. 5. There was no operative mortality and we had good surgical results regardless of patient's age.
Adult* ; Atrial Fibrillation ; Blood Pressure ; Heart Septal Defects, Atrial* ; Humans ; Mortality ; Pulmonary Artery

No abstract available.
Carcinoid Tumor*

No abstract available.
Pneumothorax* ; Risk Factors*

No abstract available.
Aortic Aneurysm, Thoracic*

No abstract available.
Cardioplegic Solutions* ; Heart* ; Thoracic Surgery*

Between April, 1984 and September 1988, 459 patients underwent cardiovascular surgery at the Yeungnam University Hospital. Of these, 355 cases were open heart surgeries and 104 cases were non-open heart surgeries. There were 237 patients of acyanotic congenital cardiac anomalies, 40 patients of cyanotic congenital cardiac anomalies, and 85 patients of acquired heart diseases. The sex ratio of cardiovascular diseases was represented as 1:1.3 in male and female. The age distribution was ranged from 1 day to 65 years old. The common congenital cardiovascular anomalies were ventricular septal defect (38.7%), patent ductus arteriosus (25.5%), atrial septal defect (20.7%), Tetralogy of Fallot (8.3%), and pulmonary stenosis (2.4%) in order of frequency. Among 87 acquired cardiovascular diseases, 81 patients underwent operation for cardiac valvular lesions, 51 patients had mitral valve replacement and 13 patients had aortic valve replacement and 17 patients had double valve replacement. The overall mortality of cardiovascular surgery was 3.3% and mortality of open heart surgery was 3.9%.
Age Distribution ; Aortic Valve ; Cardiovascular Diseases ; Clinical Study* ; Ductus Arteriosus, Patent ; Female ; Heart ; Heart Diseases ; Heart Septal Defects, Atrial ; Heart Septal Defects, Ventricular ; Humans ; Male ; Mitral Valve ; Mortality ; Pulmonary Valve Stenosis ; Sex Ratio ; Tetralogy of Fallot ; Thoracic Surgery