No abstract available.
Myocutaneous Flap* ; Pressure Ulcer*

In a randomized study of 16 pediatric patients undergone open-heart surgery, the postoperative recovery time and ventilatory support time of the patients anesthetized with fentany (fentanyl group, n=8) was compared with those of the patients anesthetized with morphine (morphine group, n=8). All patients were premedicated with 0.1 mg/kg of morphine and 0.008mg/kg of glycoppyrolate i.m. 1hr prior to anesthesia. In morphine group, anesthesia was induced with morphine 0.5mg/kg and thiopental 3 mg/kg and in fentanyl group with fentanyl 5 ug/kg and thiopental 3 mg/kg. Anesthesia was maintained with assigned opiate based upon cardiovascular signs. The total doses of opiates are 3.2mg/kg in morphine group and 34.3pg/kg in fentanyl group. In fentanyl group the time to regain consciousness (107+/-53min), ventilatory support time (209+/-53min) and the time from end of operation to extubation (589+/-82min) are significantly shorter than in morphine group (142+/-41min, 838+/-220min, 1470+/-269min, respectively). From the above results fentanyl is more suitable i.v. anesthetic agent for open-heart surgry in respect of postoperative ventilatory care.
Anesthesia ; Consciousness ; Fentanyl* ; Heart* ; Humans ; Morphine* ; Thiopental

No abstract available.
Cleft Lip*

No abstract available.
Ascites*

No abstract available.
Aconitum* ; Arrhythmias, Cardiac* ; Cardiopulmonary Resuscitation*

Autonomic hyperreflexia is a syndrome of massive reflex sympathetic discharge that occurs in patients with chronic spinal cord lesions above the major sympathetic splanchnic outflow (T 4 -T6). We experienced autonomic hyperreflexia that occured in a patient with spinal cord trans-section at T5 level during general anesthesia with O2-N2O-halothane. Hypertension was controlled with intravenous infusion of sodium nitroprusside (1-2 ug/kg/min) and ventricular arrhythmia was treated with intra- venous lidocaine. We recommend that direct acting vasodilators are useful drugs to control hypertension in autonomic hyperreflexia during anesthesia in patients with chronic spinal cord injury.
Anesthesia ; Anesthesia, General* ; Arrhythmias, Cardiac ; Autonomic Dysreflexia* ; Humans ; Hypertension* ; Infusions, Intravenous ; Lidocaine ; Nitroprusside* ; Reflex ; Sodium* ; Spinal Cord Injuries* ; Spinal Cord* ; Vasodilator Agents

BACKGROUND: Dextromethorphan (DEX) is an NMDA receptor antagonist which has recently been introduced for the treatment of chronic pain mainly to reduce the central sensitization component of pain. It is also reported to reduce the pain from acute ischemia of an extremity in a rat model which has a similar mechanism as tourniquet pain. The purpose of this experiment was to see if dextromethorphan could reduce tourniquet pain in normal volunteers. METHODS: A double blind randomized cross-over test was done on ten healthy male volunteers. Each subject was orally administered with three different doses of DEX (placebo, 30, 60 mg) 1 h before the study according to a preallocated randomized table. The subject was not reallocated for the test within two weeks of the previous test. After a 10 minute acclimation period before each test, the degree of tourniquet pain measured by VAS, arterial blood pressure, heart rate, respiration rate, and pressure-evoked pain were measured before and every 5 minutes after inflation of the tourniquet until the subject felt unbearable pain. A mixed model for repeated measurement of data was used for statistical analysis (P < 0.05). RESULTS: There was no statistical difference between different doses of DEX including the placebo. Rather, there was a tendency that DEX increases the pain. And there also was a tendency that average time to reach unbearable pain was decreased by DEX (P > 0.05). CONCLUSIONS: DEX is not effective in controlling tourniquet pain in normal awake subjects.
Acclimatization ; Arterial Pressure ; Central Nervous System Sensitization ; Chronic Pain ; Dextromethorphan* ; Extremities ; Healthy Volunteers* ; Heart Rate ; Humans ; Inflation, Economic ; Ischemia ; Male ; Models, Animal ; N-Methylaspartate ; Respiratory Rate ; Tourniquets* ; Volunteers

No abstract available.
Animals ; Mice* ; Premature Birth*

No abstract available.

No abstract available.
Trisomy* ; Ultrasonography*