No abstract available.
Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans ; Infant, Newborn*

Vitamin A and its metabolite, retinoic acid, have been recommended for the treatment of psoriasis, ichthyosis, acne vulgaris and Darier's disease which resulted from abaormal regulatory function of keratinocytes. In recent years retinoic acid analogs (retinoids) have been synthesized and shown to be more potent and less toxic than retinoic acid. Since these drugs are therapeutically effective for skin diseases, only with longterm adminiatration of large doses, their toxicities must be seriously considered. The liver is the main site for both storage and excretion of vitamin A and ita derivatives, which may produce injury to the liver and other organs as a result of excess of lysosomal enzyme control. Fatty vacuoles, infiltration of inflammatory cells, focal necrosis, increase in lysosomal enzymes, distension of the RER, decrease in the ribosomes, swelling of the mitochondria, and proliferation of the SER within the hepatocytes have been observed in livers of vitamin A- as well as retinoic acid-treated rats. Its excess may also cause mucous metaplasia of secretory cells of the pancreas. (countinued...)
Acne Vulgaris ; Amphotericin B* ; Animals ; Darier Disease ; Hepatocytes ; Ichthyosis ; Keratinocytes ; Liver ; Metaplasia ; Mitochondria ; Necrosis ; Pancreas ; Psoriasis ; Rats ; Ribosomes ; Skin Diseases ; Tretinoin ; Vacuoles ; Vitamin A ; Vitamins

In these days, computing environment turns to web environment and a lot of hospitals build information system. A medical services through the web provide patients and doctors with convenience and help experts to communicate with each other. Initially, web provided static text information, but nowadays needs of interactivity between client and server is increasing. In order to diagnose heart diseases, we use 12 channel ECG, stress ECG, holter ECG, etc. These data are a lot of correlation with each other but there are little system managed them with integration. To enhance management efficiency and share medical information, it is necessary to develop integrated ECG management system based the web. In this paper, we use common object request broker architecture(CQRBA) to implement the system. The CORBA is to apply object oriented concept to web. We can implement application easily and reduce costs to maintain and repay because server objects and client objects exist independently. We developed a System to integrate these data using network and to raise management efficiency. we focus on the performance of object web and the implementation of ECG management system based on the web.
Electrocardiography* ; Heart Diseases ; Humans ; Information Systems

No abstract available.
Electrocardiography, Ambulatory*

BACKGROUND: The effects of intralesional recombinant alpha-2 interferon(IFN) in the treatment of basal cell carcinoma(BCC) and actinic keratosis(AK) would be of value in selected patients. OBJECTIVE: Our purpose is to evaluate the differences of cellular immune reactions between the responded and the unresponded cases treated with IFN. METHODS: We treated five patients with BCC and two patients with AK with the intralesional injection of recombinant alpha-2 IFN. We performed immunohistochemical stainings with paraffin-embedded specimens from the pretreated and posttreated skin lesions. RESULTS: Four patients(three with BCC and one with AK) were healed and three patients showed improvement after treatment. In immunohistochemical stainings, there was an increased number of T cells in the dermal infiltrate of the responded cases but not in the unresponded cases. CONCLUSION: Intralesional IFN may induce T cell-mediated immune response at the site of the tumor by immune modulation.
Actins* ; Carcinoma, Basal Cell* ; Humans ; Injections, Intralesional* ; Interferons* ; Keratosis, Actinic* ; Skin ; T-Lymphocytes

No abstract available.
Cholesteatoma* ; Facial Paralysis*

This study is to develop a system which offers the auto-response and the auto-call about the patient monitoring information of the heart rate, NIBP, SpO2 and overall status from a patient monitor to registered users. After detecting a dial tone by a developed ARS and confirming a registered user, this system offers the information of a required patient by ARS voice. If a user registered to an auto-calling service, this system can offer a patient monitoring information automatically and periodically for a user' s setting to a user' s hand-phone or beeper by the voice or the number. Additionally, when the patient' s emergency situation to happen, this system calls the emergency state to an registered user' s hand-phone or beeper by the voice or the number. All of the information of patient monitoring is managed by the SQL database system for easy to the data extraction and the service of the statistical information effectively.
Emergencies ; Heart Rate ; Humans ; Monitoring, Physiologic* ; Voice

A 39-year-old male patient had multiple dark brownish colored conical protruding masses on the corona of glans penis and scrotum for 1 year and coincidently tinea cruris. The lesion of corona of glans penis was a 1.5*1.5cm sized mass and scrotal lesions were 0.3*0.3 to 0.5*0.5cm sized multiple masses. Histopathologic findings revealed characteristic findings of verruca vulgaris. Skin lesions were excised.
Adult ; Animals ; Horns* ; Humans ; Male ; Penis* ; Scrotum* ; Skin ; Tinea ; Warts

Hyperlipidemia and coronary heart disease are increasing in Korea because of life-style westernization. Most diseases result from complex interaction between genetic and environmental factors. Genetic bases vary among populations and environmental factors can affect the phenotypic expression of genes. There is a need for the investigation of genetic influences on the major diseases in Korean population. ACE (angiotensin-converting enzyme) gene polymorphism has been reported to be associated with myocardial infarction. ApoE polymorphism is associated with cholesterol metabolism, atherosclerotic disease and Alzheimer's disease. The purposes of this study were to investigate the distribution of ACE and ApoE genotypes in Korean population and to evaluate the association between ACE and ApoE genotypes and plasma lipid profiles. A total of 675 apparently healthy Korean men who attended a periodic health examination were recruited. The ACE polymorphism was genotyped by PCR amplification of the 190 and 490 bp alleles. Six different genotypes of ApoE polymorphism were determined by reverse-hybridization method after PCR amplification. The frequencies of D and I alleles of ACE genotypes were 44.1% and 55.9% respectively. The allele frequencies of epsilon 2, epsilon 3 and epsilon 4 in ApoE genotypes were 5.3%, 85.4% and 9.3% respectively. Plasma total cholesterol and LDL levels were higher in DD genotype of ACE polymorphism. HDL level was lower in epsilon 4 carriers and total cholesterol and LDL were lower in epsilon 2 carriers of ApoE polymorphism. The distributions of ACE and ApoE genotypes in Korean are different from other populations and each genotype shows characteristic plasma lipid profiles. These data suggest that common genotypic variations can play a role in the pathogenesis of several clinical diseases.
Alleles ; Alzheimer Disease ; Apolipoproteins E* ; Cholesterol ; Coronary Disease ; Gene Frequency ; Genotype* ; Humans ; Hyperlipidemias ; Korea ; Male ; Metabolism ; Myocardial Infarction ; Plasma* ; Polymerase Chain Reaction

This paper is about the system using a wireless stethoscope to analysis the FFT and the time-frequency for a heart sound and to manage the collected data for a web-based system. We reformed a wireless stethoscope, connected to PC interface and added the analysis function. In result, we combined merits of an existed wireless system to be convenient for measuring the heart sound and to be available for many listener to ausculate the heart sound simultaneously, and an existed wired system to supply the various analysis functions. The heart sounds data was made into the database to search or refer to the patient data. It is possible to search and refer by the web-browser to the recorded heart sound file, the analyzed file by FFT and the STFT time-frequency method.
Heart Sounds* ; Heart* ; Humans ; Statistics as Topic* ; Stethoscopes*