Vitamin A and its metabolite, retinoic acid, have been recommended for the treatment of psoriasis, ichthyosis, acne vulgaris and Darier's disease which resulted from abaormal regulatory function of keratinocytes. In recent years retinoic acid analogs (retinoids) have been synthesized and shown to be more potent and less toxic than retinoic acid. Since these drugs are therapeutically effective for skin diseases, only with longterm adminiatration of large doses, their toxicities must be seriously considered. The liver is the main site for both storage and excretion of vitamin A and ita derivatives, which may produce injury to the liver and other organs as a result of excess of lysosomal enzyme control. Fatty vacuoles, infiltration of inflammatory cells, focal necrosis, increase in lysosomal enzymes, distension of the RER, decrease in the ribosomes, swelling of the mitochondria, and proliferation of the SER within the hepatocytes have been observed in livers of vitamin A- as well as retinoic acid-treated rats. Its excess may also cause mucous metaplasia of secretory cells of the pancreas. (countinued...)
Acne Vulgaris ; Amphotericin B* ; Animals ; Darier Disease ; Hepatocytes ; Ichthyosis ; Keratinocytes ; Liver ; Metaplasia ; Mitochondria ; Necrosis ; Pancreas ; Psoriasis ; Rats ; Ribosomes ; Skin Diseases ; Tretinoin ; Vacuoles ; Vitamin A ; Vitamins

No abstract available.
Thyroid Diseases* ; Thyroid Gland*

In 1951, Leborgen pointed out the special diagnostic importance of punctate calcifications in the diagnosis of breast cancer by mammography. Calcifications within the breast may occure in both malignant and benign diseases, the characteristic findings have been reported subsequently by many other investigators. This study was done toreevalute the significance and diagnostic value of calcifications of female breast cancers. The clinical materals were 980 cases of those underwent mammography, and 76 cases of those histopathologically diagnosis was confirmed. Fine calcifications were radiologically found in 24 cases of these 76. A morphological analysis was made inregards to the relationship between the calcific particles and various mammary diseases. The results were asfollows; 1. The irregularly fine spiculate and punctate calcifications were found in 11 cases (45.8%) of cancergroup, and rather uniformly fine smooth calcifications were found in 14 out of 52 cases (26.9%) of benign conditions. 2. In cancer group, the calcifications were finely punctate or spiculate in shape and in numerable innumber with a tendency toward formation of densely packed clusters within and adjacent to the lesional areas. Nospiculate calcifications were observed in benign conditions. There were, however, no difference in either size ordensity of particles in both benign and malignant conditions. 3. These fine calcifications of the breast detectedby mammography seem to be a useful marker in localizing so small a lesion as not to be palpable and in obtaining proper biopsy specimen.
Biopsy ; Breast Neoplasms ; Breast ; Diagnosis ; Female ; Humans ; Mammography ; Research Personnel

Since calcification or ossification of the posterior longitudinal ligament of the spine was first described inJapan in 1960 by Tsukimoto, Terayama used the term of OPLL(Ossification of Posterior Longitudinal Ligament) in1964 and mainly reported in Japanese. But recently, the incidence of the OPLL has been reported increasing amongthe non-Japanese. Because of the OPLL may be associated wtih severe neurologic symptoms, which need to havesurgical decompression, exact diagnosis and analysis are necessary. The OPLL can be diagnosed by simple spine,conventional tomography, myelography and CT. Authors analysed radiologic findings of the OPLL in 8 patients, whowere diagnosed by simple spine. Conventional tomography, myelography and CT, and then performed spinal operation,at Hanyang University Hospital from March 1980 to June 1983. The results were as followings; 1. The age range wasbetween 45 and 63 years and most prevalent age was 6th decades(63%). 2. All of the patients were male. 3. All ofthe OPLL occurred in the cervical spine and predominant at the level of C3,4 (48%). 4. The most common length ofthe OPLL was 2 vertebral level. 5. Except one, which was discontinuous at the level of disc space, all of the OPLLwere continuous in length. 6. 7 of 8 OPLL were located in the midline, but one was in right. 7. The OPLL seemed tocorrelate with spondylotic changes. 8. Of all diagnostic procedure, CT provided better and exact visualization ofthe lesion with axial scan and sagittal reconstruction.
Asian Continental Ancestry Group ; Decompression ; Diagnosis ; Humans ; Incidence ; Longitudinal Ligaments ; Male ; Myelography ; Neurologic Manifestations ; Spine

Since early 1980's high resolution ultrasound has been world-widely used for detection of cranial lesions ininfants but not widely used in korea. Authors prospectively analysed ultrasonographic findings of 107 cases whichwere confirmed by CT, autopsy or follow-up studies as supplement. the distribution of 107 cases was intracranialhematoma 40 cases, hydrocephalus 36 cases, hypoxic-ischemic encephalopathy 10 cases, porencephalic cyst 5 cases,cephalhematoma 5 cases, agenesis of corpus callosum 4 cases, medulloblastoma 2 cases and each one case of A-Vmalformation, intraventricular cyst, Dandy Walker cyst, lipoma and hydranecephaly. We could conclude thatneurosonography of infants was very useful and effective method in detection of cranial lesions such asintracranial hematoma, especially germinal matrix hemorrhage or intraventricular hemorrhage in preterm infant,hydrocephalus, hypoxic-ischemic encephalopathy and congenital anomalies.
Agenesis of Corpus Callosum ; Autopsy ; Follow-Up Studies ; Hematoma ; Hemorrhage ; Humans ; Hydrocephalus ; Hypoxia-Ischemia, Brain ; Infant ; Korea ; Lipoma ; Medulloblastoma ; Methods ; Prospective Studies ; Ultrasonography ; Walkers

No abstract available.
Ebstein Anomaly*

No abstract available.
Erythrocytes*

No abstract available.
Electrocardiography, Ambulatory*

Adenoid basal cell tumor of the prostate is a rare tumorous lesion that can be misdiagnosed as adenocarcinoma of the prostate. The malignant potential of adenoid basal cell tumor remains uncertain due to small number of reported cases. This 66-year-old man presented with symptoms of urinary tract obstruction. Under the impression of benign prostatic hyperplasia, a transurethral resection of the prostate (TURP) was performed. The patient was alive with no evidence of recurrence or metastasis 15 months after TURP. Microscopically, most of the lesions were composed of nodular collections of small nests of basaloid cells with peripheral palisading, and clusters of tumor cells forming cribriform pattern. Multiple areas of basal cell hyperplasia and atypical basal cell hyperpalsia were also observed. The coexistence of basal cell hyperplasia, atypical basal cell hyperpalsia, and adenoid basal cell tumor with cribriform pattern in this case supports a morphologic continuum from the benign hyperplastic lesion to malignant neoplasia.
Adenocarcinoma ; Adenoids* ; Aged ; Humans ; Hyperplasia ; Neoplasm Metastasis ; Prostate* ; Prostatic Hyperplasia ; Recurrence ; Transurethral Resection of Prostate ; Urinary Tract

A 31-year-old woman with surgically proven spinal extradural granulocytic sarcoma was examined with magnetic resonance (MR) imaging. This patient had no evidence of systemic leukemia. The signal intensities of the mass on T1-weighted and gradient echo images were higher than those of spinal cord, which were different from iso-intensity of cases reported by other authors.
Adult ; Female ; Humans ; Leukemia ; Magnetic Resonance Imaging* ; Sarcoma, Myeloid* ; Spinal Cord