1.The Effect of Spacer on the Bronchodilator Response in the First Medical Examination of Old Age.
Yang Deok LEE ; Sung Kyun SIN ; Yong Seon CHO ; Min Soo HAN
Journal of the Korean Geriatrics Society 2004;8(4):228-232
BACKGROUNDS: When measuring lung function and response to bronchodilator, MDI(metered-dose inhaler) is commonly used but unfamiliarity of its use and cold sensation by the puffed gas decrease reliability of the result. Spacer can reduce the cold freon effect and undesired oropharyngeal deposition caused by the rapid evaporation of the propellant and there are many studies which showed more effectiveness of spacer on the treatment of children with asthma but no study whether it is effective on the bronchodilator response test in the first medical examination of old age. Therefore, we tested whether the use of spacer can reduce the cold freon effect and improve the bronchodilator response in the first medical examination of old age. METHODS: Two hundred of elderly patients( 65years) who had never used MDI were measured the bronchodilator response. Subjects were randomised to either spacer-user or spacer-nonuser. Twenty minutes after 400 g fenoterol was administered, FEV1 (forced expiratory volume in one second) was measured. Bronchoconstriction was defined as a decrease in FEV1 by 10% or greater after bronchodilator inhalation. We further devided each group into normal or obstructive group, obstructive group was defined as FEV1<80% of predicted and FEV1/FVC<70%. RESULTS: In normal group, spacer-user(n=83) showed greater bronchodilator response than spacer-nonuser(n=66), 6.43% vs 3.81% respectively(p<0.05) and two case of bronchoconstriction occured only in spacer-nonuser. In obstructive group, there is no significant difference in bronchodilator response between spacer-user(n=18) and spacer-nonuser(n=33), 12.32% vs 11.16% respectively(p>0.05) but brochoconstriction(n=1) occured only in spacer-nonuser. CONCLUSION: Spacer improved bronchodilator response and prevented bronchoconstriction, in the first medical examination of old age.
Aged
;
Asthma
;
Bronchoconstriction
;
Child
;
Chlorofluorocarbons
;
Fenoterol
;
Humans
;
Inhalation
;
Lung
;
Sensation
2.A case of malignant fibrous histiocytoma with invasion into great vessels and heart which was confused with benign myxoma.
Sung Kyun SIN ; Kyung Jin LEE ; Ki Ryong SONG ; Sung Yeon CHO ; Woo Jin HYUN ; Soon Chang PARK ; Jung Kyun LEE
Korean Journal of Medicine 2004;67(5):535-539
Cardiac tumors are rare. Benign myxoma is the most common among them. Malignant fibrous histiocytoma is a tumor originating from primitive mesenchymal cell and found most commonly in four extremities. Since this disease was first described by Shah in 1978, there have been a lot of case reports of cardiac malignant fibrous histiocytoma. If originating in the heart, it is usually found in left atrium which is unusual for malignant cardiac tumor. Since the advent of the echocardiography as a diagnostic tool in the cardiac disease, a lot more cases of cardiac tumor have been reported. Here, we report a case of cardiac malignant fibrous histiocytoma in a 67 year old man presenting with dyspnea who, at first sight, seemed to have benign myxoma but turned out to have malignant fibrous histiocytoma. However, strictly speaking,the case we found is a cardiac invasion of the retroperitoneal malignant fibrous histiocytoma.
Aged
;
Dyspnea
;
Echocardiography
;
Extremities
;
Heart Atria
;
Heart Diseases
;
Heart Neoplasms
;
Heart*
;
Histiocytoma, Benign Fibrous
;
Histiocytoma, Malignant Fibrous*
;
Humans
;
Myxoma*
3.Preliminary study about the safety and effects of prophylactic intra -peritoneal hyperthermo-chemotherapeutic perfusion combined with surgery in far-advanced stomach cancers.
Jin Young KIM ; Eun Sub PARK ; Seung Kyun PARK ; Kwang Jae SONG ; Sung Kee HONG ; Sun Bok WEE ; Kil Young PARK ; Chang Woo JUNG ; Mee Kyung SIN
Journal of the Korean Surgical Society 1992;43(2):176-182
No abstract available.
Perfusion*
;
Stomach Neoplasms*
;
Stomach*
4.A case of typhlitis developed after anticancer chemotherapy in a patient with solid tumor.
Yong Bum KIM ; Su Jin LEE ; Young Hwan LEE ; Yu Kyung LEE ; Sung Kyun SIN ; Jung Sik KIM ; In Sung CHO ; Hyun Young HAN
Korean Journal of Medicine 2002;62(6):657-660
Typhlitis is a necrotizing enterocolitis of the cecum, ascending colon and terminal ileum. Typhlits has been reported in the severely neutropenic patients and likely results from a combination of neutropenia and defects in the bowel mucosa related to cytotoxic chemotherapy. This disease is most common in patients with leukemia who have undergone intensive myeloablative chemotherapy. Presumptive diagnostic criteria for typhlitis include fever, abdominal pain and tenderness, and radiologic evidence of right-sided colonic inflammation in patients with neutropenia. Recently, this disease is also reported in patients with solid tumor due to increasing challenges of high dose chemotherapy. We report a case of typhlitis developed in the circumstance of neutropenia induced by chemotherapy in a patient with malignant testicular tumor.
Abdominal Pain
;
Cecum
;
Colon
;
Colon, Ascending
;
Drug Therapy*
;
Enterocolitis, Necrotizing
;
Fever
;
Humans
;
Ileum
;
Inflammation
;
Leukemia
;
Mucous Membrane
;
Neutropenia
;
Typhlitis*
5.Korean Patients Undergoing Deceased Donor Liver Transplantation for Alcoholic Liver Disease Have Non-Inferior Survival Outcomes than for Hepatitis B Virus: a Real-World Experience without Minimum Abstinence before Transplantation.
Suk Kyun HONG ; Nam Joon YI ; Hyo Sin KIM ; Sung Woo AHN ; Kyung Chul YOON ; Hyeyoung KIM ; Kwang Woong LEE ; Kyung Suk SUH
Journal of Korean Medical Science 2017;32(6):919-925
Few studies have compared outcomes in patients undergoing liver transplantation (LT) for hepatitis B virus (HBV) and alcoholic liver disease (ALD) in Asian countries in which living donor LT (LDLT) is dominant, where HBV is endemic and where there are no strict regulations on pre-transplant abstinence for ALD. This study compared post-LT outcomes of deceased donor LT (DDLT) in patients with ALD and HBV. Data from 220 patients who underwent primary DDLT at Seoul National University Hospital from January 2010 to December 2014, including 107 with HBV and 38 with ALD, were retrospectively analyzed. Seventy-four patients (69.2%) in the HBV group and 30 (78.9%) in the ALD group had United Network for Organ Sharing (UNOS) status 2A (P = 0.250). There were no significant differences in their 1-year (90.7% vs. 92.1%) and 3-year (82.1% vs. 82.3%) overall survival rates (P = 1.000). Multivariate analysis showed that high serum gamma glutamyltransferase concentration (≥ 70 IU/L) was independently prognostic of 1-year post-LT overall survival. Survival outcomes following DDLT were similar in Korean patients with ALD and HBV, even in the absence of strict pre-transplant abstinence from alcohol as a selection criterion.
Alcoholics*
;
Asian Continental Ancestry Group
;
gamma-Glutamyltransferase
;
Hepatitis B virus*
;
Hepatitis B*
;
Hepatitis*
;
Humans
;
Liver Cirrhosis
;
Liver Diseases, Alcoholic*
;
Liver Transplantation*
;
Liver*
;
Living Donors
;
Multivariate Analysis
;
Retrospective Studies
;
Seoul
;
Social Control, Formal
;
Survival Rate
;
Tissue Donors*
6.A Case of Primary Leiomyosarcoma with Prominent Osteoclast-like Giant Cell of Lung with Cardiac Invasion.
Ki Ryong SONG ; Yongseon CHO ; Sung Kyun SIN ; Ho Seok JEON ; Woo Jin HYUN ; Yang Deok LEE ; Min soo HAN ; Ji Young RHO ; Kyung Hee KIM
Tuberculosis and Respiratory Diseases 2004;57(3):278-283
The incidence of a pulmonary leiomyosarcoma as a primary lung tumor is quite rare. We report a case of primary leiomyosarcoma with a cardiac invasion in a 76 year old man. He was admitted due to left anterior chest wall pain for one month. Chest computed tomography showed a 9x8x10cm sized , large round mass in the left upper and lower lobes, and an amorphous low density lesion within the left atrium. Chest magnetic resonance imaging showed a large round mass in the left upper and lower lobes with growth into the left atrium. A diagnosis of leiomyosarcoma with prominent osteoclast-like giant cells was made based on the microscopic and immunohistochemical findings of a permanent specimen by explothoracotomy. The pathologic features of the tumor showed round mononuclear hyperchromatic cells and multinucleated giant cells that resembled osteoclasts. The immunohistochemical staining showed that the giant cells are positive for CD68 but negative for the muscle markers while the round cells were positive for the muscle marker. The patient refused further treatment and died after two months.
Aged
;
Diagnosis
;
Giant Cells*
;
Heart Atria
;
Humans
;
Incidence
;
Leiomyosarcoma*
;
Lung*
;
Magnetic Resonance Imaging
;
Osteoclasts
;
Thoracic Wall
;
Thorax
7.Severe Calcification of the Left Atrial Wall with Left Atrial Thrombi and an Axillary Hematoma.
Seok Woo SEONG ; Kye Taek AHN ; Hye Jin KIM ; Shin Hye CHEON ; Seon Ah JIN ; Sung Kyun SIN ; Jin Ok JEONG
Korean Journal of Medicine 2012;82(6):729-733
Left atrial wall calcification is frequently observed in patients with rheumatic valvular heart disease. However, massive left atrial wall calcification, so called porcelain or coconut atrium, with left atrium thrombi is very rare. Here, we describe the case of a 67-year-old male patient with porcelain atrium, recurrent left atrial thrombi, and a spontaneous axillary hematoma after mitral valve replacement and surgical thrombectomy due to rheumatic valvular heart disease. The patient underwent two valvular surgeries 20 years prior; therefore, we determined not to perform additional surgeries because of a high risk of morbidity, mortality, and the recurrence of atrial thrombi. The patient has been maintained on daily warfarin as an anti-thrombic therapy for more than 5 years without major embolic complications.
Aged
;
Cocos
;
Dental Porcelain
;
Heart Atria
;
Heart Valve Diseases
;
Hematoma
;
Humans
;
Male
;
Mitral Valve
;
Recurrence
;
Thrombectomy
;
Thrombosis
;
Warfarin
8.Severe Calcification of the Left Atrial Wall with Left Atrial Thrombi and an Axillary Hematoma
Seok Woo SEONG ; Kye Taek AHN ; Hye Jin KIM ; Shin Hye CHEON ; Seon Ah JIN ; Sung Kyun SIN ; Jin Ok JEONG
Korean Journal of Medicine 2012;82(6):729-733
Left atrial wall calcification is frequently observed in patients with rheumatic valvular heart disease. However, massive left atrial wall calcification, so called porcelain or coconut atrium, with left atrium thrombi is very rare. Here, we describe the case of a 67-year-old male patient with porcelain atrium, recurrent left atrial thrombi, and a spontaneous axillary hematoma after mitral valve replacement and surgical thrombectomy due to rheumatic valvular heart disease. The patient underwent two valvular surgeries 20 years prior; therefore, we determined not to perform additional surgeries because of a high risk of morbidity, mortality, and the recurrence of atrial thrombi. The patient has been maintained on daily warfarin as an anti-thrombic therapy for more than 5 years without major embolic complications.
Aged
;
Cocos
;
Dental Porcelain
;
Heart Atria
;
Heart Valve Diseases
;
Hematoma
;
Humans
;
Male
;
Mitral Valve
;
Recurrence
;
Thrombectomy
;
Thrombosis
;
Warfarin
9.Expression of ssrA in non-pathogen-induced adaptation in the oral cavity through signal exchange with oral pathogens.
Sung Ryoul KIM ; Jae Woo KWAK ; Sung Ka LEE ; Seung Gon JUNG ; Man Seung HAN ; Bang Sin KIM ; Min Suk KOOK ; Hee Kyun OH ; Hong Ju PARK
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2012;38(1):14-19
INTRODUCTION: This study was conducted to evaluate ssrA expression resulting from adaptation of Escherichia coli (E. coli) to oral pathogens through signal exchange. MATERIALS AND METHODS: Human cell lines Hep2 and HT29, wild-type E. coli (WT K-12), ssrA knock-out E. coli (Delta K-12), and Scleropages aureus (S. aureus) were used. A single culture consisting of Hep2, HT29, WT K-12, and Delta K-12, and mixed cultures consisting of Hep2 and WT K-12, Hep2 and Delta K-12, WT K-12 and S. aureus , Delta K-12 and S. aureus , and Hep2, WT K-12, and S. aureus were prepared. For HT29, a mixed culture was prepared with WT K-12 and with WT K-12 and S. aureus. Total RNA was extracted from each culture with the resulting expression of ssrA, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), and p53 was evaluated by Reverse transcription polymerase chain reaction (RT-PCR). RESULTS: The expression of ssrA in a single culture of WT K-12 was lower than that observed in the mixed culture of WT K-12 with S. aureus. Greater ssrA expression was observed in the mixed culture of WT K-12 with Hep2 than in the single culture of WT K-12. The expression of NF-kappaB was higher in the mixed culture of Hep2 with Delta K-12 than that in the mixed culture of Hep2 with WT K-12, and was lowest in the single culture of Hep2. The expression of ssrA was higher in the mixed culture of WT K-12 with Hep2 and S. aureus than in the mixed culture of WT K-12 with Hep2. CONCLUSION: These results suggest that ssrA plays an important role in the mechanism of E. coli adaptation to a new environment.
B-Lymphocytes
;
Cell Line
;
Escherichia coli
;
Humans
;
Mouth
;
NF-kappa B
;
Polymerase Chain Reaction
;
Reverse Transcription
;
RNA
10.Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
Nadiar MUSSIN ; Seung Cheol OH ; Kwang Woong LEE ; Min Young PARK ; Sooin SEO ; Nam Joon YI ; Hyeyoung KIM ; Kyung Chul YOON ; Sung Woo AHN ; Hyo Sin KIM ; Suk Kyun HONG ; Dong Kyu OH ; Kyung Suk SUH
Journal of Korean Medical Science 2017;32(9):1385-1395
We estimated the effect of various immunosuppressants (ISs) and metformin (M) to provide theoretical background of optimal therapeutic strategy for de novo colon cancer after liver transplantation (LT). Three colon cancer cell lines (HT29, SW620, and HCT116) were used in in vitro studies. HT29 was also used in BALB/c-nude mice animal models. Following groups were used in both in vitro and in vivo studies: sirolimus (S), tacrolimus (T), cyclosporin A (CsA), M, metformin/sirolimus (Met/S), metformin/tacrolimus (Met/T), and metformin/cyclosporin A (Met/CsA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed and western blot analyses were performed for mTOR pathway proteins, apoptosis proteins, and epithelial-mesenchymal-transition (EMT) proteins. Tumor volume was measured for 4 weeks after inoculation. MTT-assay revealed significant cell viability inhibition in all 3 colon cancer cell lines in groups of S, M, and Met/S. Of note, group Met/S showed synergistic effect compare to M or S group. Western blot analysis showed significant low levels of all investigated proteins in groups of S and Met/S in both in vitro and in vivo experiment. Tumor growth was significantly inhibited only in the Met/S group. Combination of Met and S showed the most potent inhibition in all colon cancer cell lines. This finding might have application for de novo colon cancer.
Animals
;
Apoptosis
;
Blotting, Western
;
Cell Line
;
Cell Survival
;
Colon*
;
Colonic Neoplasms*
;
Cyclosporine
;
Immunosuppression
;
Immunosuppressive Agents
;
In Vitro Techniques*
;
Liver Transplantation
;
Metformin*
;
Mice
;
Models, Animal
;
Sirolimus*
;
Tacrolimus
;
Tumor Burden