The aim of the investigation was to study the efficacy and safety of Famotidine (Gaster), a new, potent, histamine H-receptor antagonist. The Famotidine (40 mg p.o.h.s) was administered to 22 patients with 33 peptic ulcers for 4 weeks. Follow up checking was done at 2 week and 4 week by endoscopy and physical examination. All patients were carefully evaluated at regular intervals for adverse drugh reactions by clinical and laboratory examinations. By the end of study, 97% of the ulcers were healed by endoscopically and rapid and complete relief of epigastric pain was observed in all patients. Famotidine treatment was well tolerated and no alterations in laboratory tests were noted. Therfore, Famotidine was proved effective in the treatment of peptic ulcers (especially multiple ulcers) and was well tolerted on the short-term basis.
Endoscopy ; Famotidine* ; Follow-Up Studies ; Histamine ; Humans ; Peptic Ulcer* ; Physical Examination ; Ulcer

No abstract available.
Glutathione Transferase* ; Glutathione* ; Schistosoma japonicum* ; Schistosoma*

BACKGROUND: Myelopathies are classified as intramedullary and extramedullary one on the basis of location of lesion. Though there are some characteristic clinical findings which can differentiate extramedullary from intramedullary lesions, it is not easy to tell extramedullary from intramedullary lesions in complicated cases. We performed this study to figure out the relationships between anatomic location (intramedullary or extramedullary), clinical parameters (motor and sensory symptoms and signs), and electrophysiologic findings in myelopathy. We also investigated the diagnostic value of motor evoked potential (MEP) compared with that of somatosensory evoked potential (SSEP) in myelopathy. The amplitude changes of compound muscle action potential (CMAP) after motor cortex stimulation have a lot of intra-individual and inter-individual variability, so were not used to determine pyramidal tract dysfunction in clinical ground. We analyzed CMAP amplitude changes in myelopathy. METHODS: Fifty-six patients with myelopathy demonstrated in MRI were studied. We defined abnormal CMAP amplitude changes as intra-individual inter-side amplitude ratio more than 50%. RESULTS: Lower MEP showed abnormal findings in 93% of tests and lower SSEP, 37% (p<0.05). The correla-tions between clinical parameters and electrophysiologic findings were higher in lower MEP (71%) than lower SSEP (42%) (p<0.05). CONCLUSIONS: The results of this study suggest that MEP is more useful than SSEP for detecting spinal cord dysfunction but as false positivity of lower MEP was considerable, MEP and SSEP are reciprocal diagnostic method for myelopathy. SSEP and MEP do not have significant diagnostic values in differentiating extramedullary from intramedullary myelopathy. The inter-side CMAP amplitude difference may indicate subclinical spinal cord dysfunction.
Action Potentials ; Evoked Potentials ; Evoked Potentials, Motor* ; Evoked Potentials, Somatosensory ; Humans ; Magnetic Resonance Imaging ; Motor Cortex ; Pyramidal Tracts ; Spinal Cord ; Spinal Cord Diseases*

No abstract available.
Animals ; Clone Cells* ; Cloning, Organism* ; DNA, Complementary* ; Leptin* ; Rats* ; Receptors, Leptin*

BACKGROUND: The level of physical adaptation through active lifestyle can result in changes in appetite; and caused by physical activity and exercise, physical adaptation may change carbohydrate and fat metabolism during exercise. This study investigated the differences in carbohydrate and fat metabolism after moderate treadmill running and the difference in appetite response before and after exercise in active, regularly exercising individuals and those inactive. METHODS: We analyzed the effects of moderate physical activity (70% of oxygen uptake reserve, 30 minutes on the treadmill) on free fatty acids, glucose, growth hormone, insulin and an appetite visual analogue scale (VAS). Our subjects included 28 healthy males who were divided into two groups, the activity group (n=14) and the inactivity group (n=14) according to the International Physical Activity Questionnaire (IPAQ). The serum samples and VAS were collected at pre, post and 30 min post-exercise. RESULTS: The results of the serum analysis showed no significant effects on free fatty acids, glucose, growth hormone and insulin between the groups, but showed significant changes in free fatty acids and growth hormone between points of measurement. Significant increases in VAS were seen with moderate exercise in both groups, with the inactivity group expressing greater hunger than the activity group. CONCLUSIONS: This study found that inactive persons were hungrier than active persons after moderate exercise. This information might be useful to staff and participants of weight loss programs.
Appetite ; Energy Metabolism ; Exercise ; Fatty Acids, Nonesterified ; Glucose ; Growth Hormone ; Humans ; Hunger ; Insulin ; Life Style ; Male ; Motor Activity ; Oxygen ; Running ; Weight Reduction Programs ; Surveys and Questionnaires

The authors present 4 cases of spondylolisthesis, 1 case of spondylolysis and 2 cases of Tbc spondylitis of lower lumbar spine treated by posterior lumbar interbody fusion, with follow-up periods of 3 months to 2 years. All cases had severe low back pain. Other common manifestations were radiating pain to leg. All cases were treated with laminectomy, which included a mesial facetectomy followed by posterior lumbar interbody fusion. The spondylolisthesis was reduced to zero degrees in three cases by the use of vertebral spreader. The fusion rate of intervertebral space in radiological finding was 100%. On case become pain free, 4 cases had mild degree of pain, 1 case had moderate degree of pain and 1 case was not improved. The authors conclude that posterior lumbar interbody fusion is applicable as a surgical treatment of patient with spondylolisthesis and Tbc spondylitis.
Follow-Up Studies ; Humans ; Laminectomy ; Leg ; Low Back Pain ; Spine ; Spondylitis ; Spondylolisthesis ; Spondylolysis

Uterine torsion is defined as the mtation of more than 45 degrees around the long axis of the uterus or a rotation which is severe enough to produce symptoms. Torsion of the human pregnant uterus is a very rare complication. The diagnosis is problematic and is often made during a cesrean section due to inhibited labor. Torsion of the human pregnant uterus can be caused by myoma or other uterine abnormalities, ovarian cysts, adhesions, abnormal fetal presentations, or fetal abnormalities ( though no cause can be found in about 20% of cases ). Uterine torsion produces symptoms of varying severity depending on the degree of rotation, and duration of the pregnancy. High mortality rates for both mother and infant have been reported. We experienced one case of the torsion of term pregnant uterus and report this case with a brief review of the concerned literature.
Axis, Cervical Vertebra ; Diagnosis ; Female ; Fetus* ; Humans ; Infant ; Mortality ; Mothers ; Myoma ; Ovarian Cysts ; Pregnancy ; Uterus*

No abstract available.
Prostate*

No abstract available.
Myocardial Infarction*

BACKGROUND: Mannitol is widely used in neurosurgical patients and may induce an increase in serum potassium concentration according to doses and administration rates with unknown mechanism. The treatment of hyperkalemia is aimed at eliminating the causes and includes calcium, sodium bicarbonate, glucose with insulin, loop diuretics and hyperventilation. This study was undertaken to observe the effects of hyperventilation on the serum potassium concentration following infusion of mannitol (2.0 gm/kg). METHODS: We studied 30 patients who were operated brain aneurysm clipping surgery and were divided into 3 groups (n=10). In control group, mild hypocapnia was maintained (PaCO2, 32 2 mmHg) before and after mannitol infusion. In group I, moderate hypocapnia was maintained (PaCO2, 27 2 mmHg) before and after mannitol infusion. In group II, mild hypocapnia (PaCO2, 32 2 mmHg) was maintained before 30 minutes of mannitol infusion and moderate hypocapnia (PaCO2, 27 2 mHg) after mannitol infusion. We started infusion of 20% mannitol with a dosage of 2.0 gm/kg, 15~20 min after cranium was opened. RESULTS: The changes of serum potassium were as follows (Mean SD mEq/l) (just before and 15min, 30min, 60min after mannitol infusion): 3.79 0.48, 4.66 0.60, 4.44 0.48, 4.13 0.40 (Control group), 3.62 0.18, 3.63 0.42, 4.14 0.51, 3.95 0.33 (Group I), 3.76 0.20, 3.91 0.15, 4.11 0.30, 4.04 0.23 (Group II). After 15 minutes of mannitol infusion, the serum potassium levels of group I and II were lower than that of control group (p<0.05) and there was no significant difference between group I and II. CONCLUSIONS: These results suggest that hyperventilation may blunt the increase in serum potassium concentration following rapid infusion of high dose mannitol.
Calcium ; Glucose ; Humans ; Hyperkalemia ; Hyperventilation* ; Hypocapnia ; Insulin ; Intracranial Aneurysm ; Mannitol* ; Potassium* ; Skull ; Sodium Bicarbonate ; Sodium Potassium Chloride Symporter Inhibitors