We examined the nuclear overexpression of p53 protein by immunohistochemical analysis of the deparaffinized tumor tissue specimens from 45 patients with transitional cell carcinoma of the bladder. The data were then correlated with conventional prognostic variables such as histologic tumor grade, stage and DNA ploidy. In addition, we related the expression of the 53 protein to indicators of cellular proliferative activity, including proliferating cell nuclear antigen(PCNA), mean number of silver-binding nucleoar organizer regions(AgNORs) per nucleus, flow cytometric S-phase fraction(SPF) and proliferation index(PI). Survivals of the patients according to mutant p53 protein expression, stratified by histologic tumor grade and stage were analyzed.None of the urothelial cells from normal bladder specimens showed nuclear expression of mutant p53 protein. Mutant p53 protein expression was not associated with histologic tumor grade, stage, flow cytometric SPF and PI, but there was an association between mutant p53 protein expression and flow cytometric DNA ploidy with marginal statistical significance(p=0.0892) There was statistically significant difference of mutant p53 protein expression between low and high AgNORs counts per nucleus(p=0.0108), but here was no significant correlation between mutant p53 protein expression and PCNA expression rate. Using Kaplan-Meier analysis, we could not identify the statistically significant difference of survivorship between patients with and without mutant p53 expression. These results suggest that immunohistochemical analysis of bladder cancer specimens could be a good method of screening for the presence of mutant p53 protein, and mutant p53 protein expression may be an indicator of bladder cancer with more proliferative and/or aggressive activity, but it may not be an clinically useful prognostic factor in patients with bladder TCC.
Carcinoma, Transitional Cell ; DNA ; Humans ; Immunohistochemistry* ; Kaplan-Meier Estimate ; Mass Screening ; Mutant Proteins ; Nucleolus Organizer Region* ; Ploidies ; Prognosis ; Proliferating Cell Nuclear Antigen* ; Survival Rate ; Urinary Bladder Neoplasms ; Urinary Bladder*

Urethral stricture usually follows the urethral rupture and periodical urethral soundation, which is an annoying procedure for. patients, is the usual method of treatment throughout their life. A case of urethral stricture who was successfully treated with modified Cecil's Operation, is presented.
Humans ; Rupture ; Urethral Stricture*

No abstract available.
Urinary Tract Infections* ; Urinary Tract*

No abstract available.
Humans ; Hyperplasia* ; Prostate* ; Transurethral Resection of Prostate* ; Urinary Bladder Neck Obstruction

This Study was designed to characterize the unfavorable prognostic factors of renal cell carcinoma through reviewing 27 cases with radical nephrectomy during the past 10 years from 1976 through 1986. The presence or absence of tumor invasion into renal capsule, perinephric fat, renal vein, regional lymph node, pelvis and/or ureter, hematuria at the time of first examination and the difference in the size of tumor and tumor cell type were studied. The 100 person-year mortality rates were analyzed with the chosen prognostic variables. Tests of significance between the difference in mortality rates of each two groups with or without a given characteristics were performed with Z-test. Author results as follows. : 1. The survival rate was decreased independently by the unfavorable factors such as the presence of tumor invasion into renal vein, regional lymph node, pelvis and/or ureter and tumor cell type other than clear cell(P<0.001, <0.001, <0.001, <0.05 respectively). 2. The survival rate was not affected by the following factors such as the presence or absence of hematuria at the time of first examination, tumor invasion into renal capsule, perinephric fat and the difference in size of tumor.
Carcinoma, Renal Cell* ; Hematuria ; Lymph Nodes ; Mortality ; Nephrectomy ; Pelvis ; Prognosis ; Renal Veins ; Survival Rate ; Ureter

No abstract available.
Adhesives* ; Circumcision, Male* ; Female ; Male ; Wounds and Injuries*

The varicocele may cause a male infertility and mild subjective symptoms such as heavy sensation, dragging pain over the ipsilateral scrotum. One of the therapeutic method of the varicocele is a high ligation of internal spermatic vein of affected side. We have performed the venography of internal spermatic vein during operation in 10 cases to detect the collateral circulation from January 1980 to June 1981. The following results were obtained. 1. The venograms of internal spermatic vein showed left to right anastomosis prepubically in 1 case. anastomosis of left internal spermatic vein with ductus deferens vein in 2 cases and no anastomosis in 7 cases. 2. After high ligation of internal spermatic vein, the clinical symptoms and size of varicocele decreased within 3 days in 4 cases and within 7 days in another 4 cases postoperatively, however no decrease noted in 2 cases until 3 months to 12 months postoperatively, This 2 cases showed anastomosis with ductus deferens vein. 3. Preoperative semen analysis revealed oligospermia 5 cases, asthenospermia in 2 cases and low percentage of normal form of sperm in 4 cases. Postoperative semen analysis showed increase of sperm count in 4 cases of which had been oligospermia, slight improvement noted in 1 case of asthenospermia and in 3 cases of low normospermia. 4. 2 cases In which the spermatic vein was anastomosed with left ducts deferens vein seemed to b associated with obstruction of left common iliac vein.
Collateral Circulation ; Iliac Vein ; Infertility, Male ; Ligation ; Male ; Oligospermia ; Phlebography* ; Scrotum ; Semen Analysis ; Sensation ; Sperm Count ; Spermatozoa ; Varicocele* ; Vas Deferens ; Veins

15 male patients who received total cystectomy with ileal conduit for bladder tumor were reviewed in relation to the incidence of urethral involvement. Of 15 patients six had recurrent transitional cell carcinoma in the urethral remnant among them one (1/15) received subsequent therapeutic urethrectomy and remaining 5 patients underwent delayed therapeutic urethrectomy after confirmation of urethral tumor but 9 of the 15 had only received total cystectomy. We concluded that the remaining urethra might constitute a potential hazard for further tumor formation. We believe that prophylactic urethrectomy is the way to prevent the recurrence of the malignancy who have multiple tumors, concurrent upper tract tumors, and involvement of the trigone or prostatic urethra.
Carcinoma, Transitional Cell* ; Cystectomy* ; Humans ; Incidence ; Male ; Recurrence ; Urethra* ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urinary Diversion*

No abstract available.
Vasovasostomy*

Fifty cases of acute uncomplicated urinary tract infection were selected and 3.0gm of Carfecillin was given for one day in two doses. The clinical and bacteriological results were compared with the results of 32 cases of the urinary tract infection who was given 200 mg of Doxycycline daily for 7 days. Of 50 patients receiving Carfecillin only 23 cases were sensitive to Carfecillin though 32 patients receiving Doxycycline were all sensitive to Doxycycline on prior to treatment urine culture. Carfecillin was effective in 34 cases among 38 cases of cystitis while Doxycycline was effective in 12 cases among 21 cases of cystitis. In 7 out of 12 cases of pyelonephritis Carfecillin was effective, while Doxycycline was effective in 9 out of 11 cases. Among 23 cases which were sensitive to Carfecillin, Carfecillin single day treatment was effective in 13 out of 17 cases of cystitis and 4 out of 6 cases of pyelonephritis. Both Carfecillin and Doxycycline showed good efficacy to E-coli, Staphylococcus aureus, Klebsiella, Streptococcus and Enterobacter. A single day treatment of Carfecillin was as effective as a conventional treatment of Doxycycline for the treatment of uncomplicated urinary tract infections.
Carfecillin* ; Cystitis ; Doxycycline ; Enterobacter ; Humans ; Klebsiella ; Pyelonephritis ; Staphylococcus aureus ; Streptococcus ; Urinary Tract Infections* ; Urinary Tract*