We examined the nuclear overexpression of p53 protein by immunohistochemical analysis of the deparaffinized tumor tissue specimens from 45 patients with transitional cell carcinoma of the bladder. The data were then correlated with conventional prognostic variables such as histologic tumor grade, stage and DNA ploidy. In addition, we related the expression of the 53 protein to indicators of cellular proliferative activity, including proliferating cell nuclear antigen(PCNA), mean number of silver-binding nucleoar organizer regions(AgNORs) per nucleus, flow cytometric S-phase fraction(SPF) and proliferation index(PI). Survivals of the patients according to mutant p53 protein expression, stratified by histologic tumor grade and stage were analyzed.None of the urothelial cells from normal bladder specimens showed nuclear expression of mutant p53 protein. Mutant p53 protein expression was not associated with histologic tumor grade, stage, flow cytometric SPF and PI, but there was an association between mutant p53 protein expression and flow cytometric DNA ploidy with marginal statistical significance(p=0.0892) There was statistically significant difference of mutant p53 protein expression between low and high AgNORs counts per nucleus(p=0.0108), but here was no significant correlation between mutant p53 protein expression and PCNA expression rate. Using Kaplan-Meier analysis, we could not identify the statistically significant difference of survivorship between patients with and without mutant p53 expression. These results suggest that immunohistochemical analysis of bladder cancer specimens could be a good method of screening for the presence of mutant p53 protein, and mutant p53 protein expression may be an indicator of bladder cancer with more proliferative and/or aggressive activity, but it may not be an clinically useful prognostic factor in patients with bladder TCC.
Carcinoma, Transitional Cell ; DNA ; Humans ; Immunohistochemistry* ; Kaplan-Meier Estimate ; Mass Screening ; Mutant Proteins ; Nucleolus Organizer Region* ; Ploidies ; Prognosis ; Proliferating Cell Nuclear Antigen* ; Survival Rate ; Urinary Bladder Neoplasms ; Urinary Bladder*

This Study was designed to characterize the unfavorable prognostic factors of renal cell carcinoma through reviewing 27 cases with radical nephrectomy during the past 10 years from 1976 through 1986. The presence or absence of tumor invasion into renal capsule, perinephric fat, renal vein, regional lymph node, pelvis and/or ureter, hematuria at the time of first examination and the difference in the size of tumor and tumor cell type were studied. The 100 person-year mortality rates were analyzed with the chosen prognostic variables. Tests of significance between the difference in mortality rates of each two groups with or without a given characteristics were performed with Z-test. Author results as follows. : 1. The survival rate was decreased independently by the unfavorable factors such as the presence of tumor invasion into renal vein, regional lymph node, pelvis and/or ureter and tumor cell type other than clear cell(P<0.001, <0.001, <0.001, <0.05 respectively). 2. The survival rate was not affected by the following factors such as the presence or absence of hematuria at the time of first examination, tumor invasion into renal capsule, perinephric fat and the difference in size of tumor.
Carcinoma, Renal Cell* ; Hematuria ; Lymph Nodes ; Mortality ; Nephrectomy ; Pelvis ; Prognosis ; Renal Veins ; Survival Rate ; Ureter

Urethral stricture usually follows the urethral rupture and periodical urethral soundation, which is an annoying procedure for. patients, is the usual method of treatment throughout their life. A case of urethral stricture who was successfully treated with modified Cecil's Operation, is presented.
Humans ; Rupture ; Urethral Stricture*

No abstract available.
Urinary Tract Infections* ; Urinary Tract*

No abstract available.
Humans ; Hyperplasia* ; Prostate* ; Transurethral Resection of Prostate* ; Urinary Bladder Neck Obstruction

Female urethral syndrome is a common disorder in women consisted of urinary frequency, urgency, dysuria and suprapubic discomfort without any specific organic changes on corroborative physical and laboratory findings. Allergy, psychic factors, senile atrophy, obstruction and chronic infection of periurethral gland have been implicated at etiologic factors. From Jan. 1982 to Jan. 1983, 22 patients of the female urethral syndrome underwent laboratory examinations and cystourethroscopic examinations. In addition, both 22 cases of the patient group who showed female urethral syndrome with polypoid at the bladder neck and the same numbers of 22 as the control group who had been treated at this hospital with other medical diseases were tested the Minnesota Multiphasic Personality Inventory. Concomitantly, no specific abnormalities were found in both urine findings and cystourethroscopic findings except polypoids at the bladder neck in 22 cases. Female urethral syndrome patients in this study scored up significantly higher on the hypochondriasis, hysteria and depression scales than did the control group, and the results revealed evidence of conversion and psychosomatic etiology. All 22 cases were treated with transurethral fulguration, urethral dilatation and antibiotics. Chlordiazepoxide was added to above mentioned treatment in 15 cases which scored up significantly higher on hypochondriasis, hysteria, and depression scales among 22 cases Excellent result were obtained in 12 out of 15 cases while only 3 out of 7 cases which didn`t add chlordiazepoxide in their treatment had good result.
Anti-Bacterial Agents ; Atrophy ; Chlordiazepoxide ; Depression ; Dilatation ; Dysuria ; Female* ; Humans ; Hypersensitivity ; Hypochondriasis ; Hysteria ; Minnesota* ; MMPI* ; Neck ; Urinary Bladder ; Weights and Measures

The term endometriosis refers to ectopic endometriume. It most often involves the pelvic organs, including ovaries, broad and round ligaments, fallopian tubes, cervix, vagina and the pouch of Douglas. We report a case of vesical endometriosis in a 4- year old female patient and review literature. Segmental resection of this mass with involved bladder resulted in cure and this lesion was confirmed histologically as endometriosis of the bladder.
Cervix Uteri ; Endometriosis* ; Endometrium ; Fallopian Tubes ; Female ; Humans ; Ovary ; Round Ligament of Uterus ; Urinary Bladder ; Vagina

A clinical observation was undertaken on 7 cases of epididymal tuberculosis mimicking the symptoms and signs of acute epididymitis and 24 cases of all tuberculous epididymitis which were seen during the period from September 1983 to July 1987. The results obtained were as follows. 1. A total of 7 cases of epididymal tuberculosis mimicking the symptoms and signs of acute epididymitis corresponds to 29% of epididymal tuberculosis(24 cases). 2. The highest occurrence was observed in the age of 30 to 39(5 cases). 3. Lateralization showed 5 cases in the right, 2 cases in the left and none in both. 4. Presenting symptoms and signs were painful scrotal swelling in all 7 cases, fever 4 cases, tender epididymal nodule 4 cases and local heating 2 cases but beading of vas and scrotal fistula was not found. 5. In urine examination, pyuria was observed in 5 cases, hematuria in 1 case and no tubercle bacilli was observed. 6. Among 7 cases, we observed that epididymal tuberculosis were associated with pulmonary tuberculosis, active or inactive, in 5 cases and renal tuberculosis in 1 case.
Epididymitis* ; Fever ; Fistula ; Heating ; Hematuria ; Hot Temperature ; Male ; Pyuria ; Tuberculosis* ; Tuberculosis, Pulmonary ; Tuberculosis, Renal

No abstract available.
Skull Base* ; Skull*

Bethanechol promotes bladder emptying by acting on postganglionic parasympathetic effector cells within detrusor muscle to elicit a contraction and is widely used to enhance bladder emptying for incomplete lower motor neuron lesion, idiopathic hypotonic bladder end postoperative urinary retention. However its effects on bladder outlet is inconclusive. Therefore, in vitro study for the effects of bethanechol on the muscle strip from the rabbit bladder neck were undertaken. Ten male white rabbit bladders were divided into body, base and neck and contractile responses of three strips were done. Bethanechol chloride produces most potent contractile response on the bladder body and comparatively less on the bladder base and bladder neck in a dose-dependant manner. Maximal contractile pressures of bladder body and bladder neck were 6.29+/-0.72 and l.22+/-0.53gm tension respectively. Norepinephrine produce maximal contractile responses of 2.09+/-0.49gm tension on bladder body. 1.15+/-0.39 on bladder base and 2.6+/-0.55 on bladder neck. Contractile response or the bladder neck to bethanechol was 50% of those to norepinephrine. These results indicated that bethanechol produce contractile response on the rabbit bladder neck in some degree but weaker than those by norepinephrine.
Bethanechol* ; Humans ; Male ; Motor Neurons ; Neck* ; Norepinephrine ; Urinary Bladder* ; Urinary Retention