1.A Case of Congenital Solitary Morphea Profunda.
Hyung Jin AHN ; Eung Ho CHOI ; Sung Ku AHN ; Sang Min HWANG ; Sung Hun LEE
Annals of Dermatology 2000;12(4):306-309
A 4-year-old boy has had a solitary sclerotic depressed plaque on the right anterior chest since birth. The histopathologic findings are consistent with morphea profunda: thickening, hyalinization, and homogenization of collagen bundles in the dermis and subcutaneous tissues, admixture with a prominent lymphocytic and plasma cell infiltrate, and sweat glands en-trapped between the thickened collagen bundles. We report a case of congenital solitary morphea profunda.
Child, Preschool
;
Collagen
;
Dermis
;
Humans
;
Hyalin
;
Male
;
Parturition
;
Plasma Cells
;
Scleroderma, Localized*
;
Subcutaneous Tissue
;
Sweat Glands
;
Thorax
2.Von Recklinghausen' s Disease with Plexiform Neurofibroma , Giant Pigmentation , and Skeletal Abnormalities.
Sang Min HWANG ; Sung Ku AHN ; Beom Joo LEE ; Won Soo LEE ; Eung Ho CHOI
Korean Journal of Dermatology 1995;33(6):1179-1183
Plexiform neurofibroma is considered a pathognomic of Von Recklinghousen's disease, which involves the deep and large nerve trunk. These are large irregular nerve fascicles which result from an increase in endoneural matrix within individual nerve facicles, without an increased number of nerve fibers. We experenced a case of Von Recklinghausen's disease in a 24 year-old male who had variable cutaneous skeletal, and CNS lesions. He presented multiple neurofibromas, cafe-au-lait spots, and axillary freckles as common cutaneous lesions of NF-I and giant pigmentation, sacral hypertrichosis, and plexiform neurofibroma as unusual cutaneous lesions. Also he had a scoliosis, bowing deformity of the humerous and wedging deformity of the body of the 5th cervical spine as a skeletal manifestation and cortical calcification in the occipital area as a CNS manifestation.
Cafe-au-Lait Spots
;
Congenital Abnormalities
;
Humans
;
Hypertrichosis
;
Male
;
Melanosis
;
Nerve Fibers
;
Neurofibroma, Plexiform*
;
Neurofibromatoses
;
Neurofibromatosis 1
;
Pigmentation*
;
Scoliosis
;
Spine
;
Young Adult
3.Pyoderma Gangrenosum Treated with Cyclosporine.
Kyun Tae KIM ; Won Soo LEE ; Eung Ho CHOI ; Sung Ku AHN
Korean Journal of Dermatology 1995;33(6):1124-1128
We present herein a case of pyoderma gangrenosum, which showed good response to cyclosporine therapy. The patient, a 47-year-old man, had suffered from a skin defect on the left anterior chest 2 months before the rapidly spreading pustules and ulcer with an inflammed, irregular undermined border appeared together with a hemorrhagic base which developed on his left anterior chest and upper abdomen. Cyclosporine was given orally in a dose of 150mg three times daily for 2 weeks, and tapering to 100mg three times daily for the next 3 weeks. Clinical improvement was observed after 14 day's treatment and all the skin lesions were replaced by granulation tissue with epithelialization after 35 day's treatment. After the 5-week period of treatment, blood urea nitrogen and creatinine rose to 29 and 1.8 mg/dl. Cyclosporine was stopped and then the patient was given prednisolone (10mg/day) in addition to dapsone(50mg/day) for 1 month. Recurrence has not been observed.
Abdomen
;
Blood Urea Nitrogen
;
Creatinine
;
Cyclosporine*
;
Granulation Tissue
;
Humans
;
Middle Aged
;
Prednisolone
;
Pyoderma Gangrenosum*
;
Pyoderma*
;
Recurrence
;
Skin
;
Thorax
;
Ulcer
4.The Effect of Bentonite and Glycolic Acid on the Stratum corneum.
San KIM ; Sang Min HWANG ; Eung Ho CHOI ; Sung Ku AHN ; Seung Hun LEE
Annals of Dermatology 2001;13(4):205-210
BACKGROUND: Bentonite clay, which is a major component of mud pack, has been used for various purposes in cosmetics. Glycolic acid is known to be effective in the treatment of acne. Al-though those products are used widely, information on the mode of action and effects on the skin are little and controversial till now. OBJECTIVE: To investigate whether bentonite alone, or bentonite with glycolic acid in mixed formulation affect the stratum corneum leading to alteration on cutaneous barrier function and whether those products alter the lipid lamellae and desmosomes of corneocytes. MATERIALS AND METHODS: Mud pack-type ointment of bentonite, bentonite and 5% glycolic acid formulation, bentonite and 10% glycolic acid formulation were applied on the volar fore-arm of the five healthy men and flank skin of five 6-8 week old hairless mice. Transepidermal water loss and capacitance were measured. Electron microscopic examination after ruthenium tetroxide postfixation was performed on the flank skin of the mice. RESULTS: Transepidermal water loss(TEWL) increased immediately and normalized 4 to 6 hours later after removal of vapor permeable membrane in both mouse and human. Capacitance did not show any evidence of change in the water content of the stratum corneum. Electron microscopic examination revealed that lipid lamellae and desmosome of corneocytes were not de-graded, but lamellar body secretion and partially electron-lucent material was-increased in 10% glycolic acid and bentonite mixture-treated area. CONCLUSION: Barrier function of stratum corneum is not disturbed by bentonite and glycolic acid formulations at the concentration used. Barrier structures are not disrupted, but lamellar body secretion and partially electron-lucent material was increased by bentonite and glycolic acid formulations at higher concentration.
Acne Vulgaris
;
Animals
;
Bentonite*
;
Desmosomes
;
Humans
;
Male
;
Membranes
;
Mice
;
Mice, Hairless
;
Mud Therapy
;
Ruthenium
;
Skin
;
Water
5.Electron Microscopic and Immunohistochemical Comparative Studies of Bullous Congenital Ichthyosiform Erythroderma and Epidermal Nevus Histologically Showing Epidermolytic Hyperkeratosis.
Joon CHUNG ; Sung Ku AHN ; Eung Ho CHOI ; Won Soo LEE
Korean Journal of Dermatology 1995;33(3):413-420
BACKGROUND: Although the histologic picture of epidermolytic hyperkeratosis is diagnostic for bullous congenital ichthyosiform erythrokerma (BCIE), it is not specific for it. It is found also in several other conditions, that is, linear epidermal nevus, epidermolytic keratisis palmaris et plantaris and epidermolytic acnthoma. Among these, BCIE is caused by mutations of the defferentiation s0pecific keratins K1 and K1-. These mutations produce a weakened cytoskeleton that is prone to collapse resulting I cell fragility and lysis. But the pathogenesis of epidermal nevus showing the similar histologic feature with BCIE is not known. OBJECTIVE: The purpose of our study is to conpare the electron microscopic picture and the immunohistochemical features, and to find the possible pathogenesis of both diseases. METHODS: We evaluated the clinical, histopathologic nd electron microscopic features of 5 BCIE cases and 14 epidermal nevus cases which were histologically diagnosed with epidermolytic hyperkeratosis at the department of dermatology at Wonju Christian Hospital, Shinchon Severance Hospital and Yongdong Severance Hospital, from January 1981 to June 1994. The immunohistochemical staining(PAP method) using monoclonal antibody against cytokeratin was performed on BCIE and epidermal nevus. RESULTS: Light microscopy of both BCIE and epidermal nevus showed the same histologic changes including hyperkeratosis, increased keratohyaline granules, acanthosis and perinuclear vacuolization of upper malpighia layer. Electron mioroscopic findings in both diseases were similar. Aggregation of tonofilaments is noted in the squamous cells, but is not evident in basal cells.In immunohistochemical study of both diseases, 34betaE12 is stained in the whole epidermis and is stuonger ex0ressed in the basal layer tan suprabasal layers. LP34 staining is evident in suprabasal cell layers up to the cornified cell layer. CONCLUSION: Electron microscopy and immunohistochemical study of both diseases showed the same finding. We thind that a defect in the differentiation specific keratins, K1 and K10 is perhaps involved in epidermal nevus histologically showing epidermolytic hyperkeratosis as in BCIE.
Cytoskeleton
;
Dermatology
;
Epidermis
;
Gangwon-do
;
Hyperkeratosis, Epidermolytic*
;
Intermediate Filaments
;
Keratins
;
Microscopy
;
Microscopy, Electron
;
Nevus*
;
Triacetoneamine-N-Oxyl
6.Two cases of supernumerary nipple.
Kyun Tae KIM ; Eung Ho CHOI ; Sung Ku AHN ; Beom Joo LEE ; Won Soo LEE
Korean Journal of Dermatology 1993;31(5):784-787
Supernunmerary nipple is a developmental anomaly occuring alon, the course of the embryological milk lines. This entity has receieved little attention in the dermatologic literature and has been confused with a pigmented nevus in some cases. We have experienced two ease of the more unusual form of supern umerary nipple. According to the Kajavas classification, our caes are classified as polithelia pilosa and complete breast with nipple.
Breast
;
Classification
;
Milk
;
Nevus, Pigmented
;
Nipples*
7.A Case of Herpes Zoster with Generalized Varicelliform Eruption.
Hyun Joo CHOI ; Sung Ku AHN ; Seung Hun LEE ; Won Soo LEE
Annals of Dermatology 1995;7(4):324-326
We report a case of herpes zoster with generalized varicelliform eruption. A 56-year-old male presented with rice-sized erythematous grouped ruptured or crusted vesicles with a band-like distribution on the left chest and back and generalized rice-to-pea-sized erythematous vesicles on his whole body. Histologic examination revealed ballooning degeneration and multi-nucleated giant cells in the epidermis and leukocytoclastic vasculitis in the dermis.
Dermis
;
Epidermis
;
Giant Cells
;
Herpes Zoster*
;
Humans
;
Male
;
Middle Aged
;
Thorax
;
Vasculitis
8.Seborrheic Keratosis: A Clinical and Histopathological Study.
Sung Ku AHN ; Dong Hwan SHIN ; Kwang Gil LEE ; In Joon CHOI
Korean Journal of Pathology 1986;20(4):484-490
A total of 127 cases of seborrheic keratosis examind at the Dept. of Pathology, Yonsei University School of Medicine during 1980~1986 was reviewed. The results were as follow; 1) Sex distribution showed without preponderance with male; Female ratio of 1.05:1. 2) Age distrubution were 10~19 years 0.8%, 20~29 years 4.7%, 30~39 years 14.2%, 40-49 years 25.2%, 50~59 years 29.1%, 60~69 years 17.3%, 70~79 years 6.3% and neck (3.7%). 3) The most common site was face (44.8%), followed by trunk (29.8), lower extremities (10.4%), scalp (6.7%) and neck (3.7%). 4) The clinical diagnoses were sebrorrheic keratosis (47%), nevus (15.4%), verruca (12%), malignant melanoma (7.7%), actinic keratosis (3.4%), pyogenic granuloma (2.6%), mass (2.6%), basal cell epithelioma (0.9%), corn (0.9%), leproy (0.9%), and angiokeratoma (0.9%). 5) The distributions of the light microscopic diagnosis were acanthotic 52 cases (42.9%), hyperkeratotic 33 cases (30%), irritated 17 cases (13.4%), adenoid 15 cases (11.8%), clonal 3 cases (2.4%), melanoacanthoma 1 case (0.8%) and mixed 6 cases (4.7%). 6) The lesions measured from 0.2 cm to 3 cm in maximum diameter and its color was light brown to black with sharply demarcated papule, pladque or nodule.
Female
;
Male
;
Humans
9.A Case of Multiple Trichilemmal Cysts.
Hae Shin CHUNG ; Nam Ho LEE ; Eung Ho CHOI ; Won Soo LEE ; Sung Ku AHN
Annals of Dermatology 1997;9(3):228-230
A case of multiple trichilemmal cysts (TC) is presented. TC is known to be a kind of keratinous cyst with lining cells showing trichilemmal keratiniration. A 63-year-old female patient presented with a 30 year duration of increasing in size and number of twenty five nodular lesions on the scalp. All twenty five TC on the scalp were totally excised and examined microscopically. However, the evidence of proliferation or malignant change like the previous case reports was not found in our case.
Female
;
Humans
;
Middle Aged
;
Scalp
10.Acral Lentigenous Malignant Melanoma Associated with Pseudocarcinomatous Hyperplasia.
Kyun Tae KIM ; Sung Ku AHN ; Eung Ho CHOI ; Won Soo LEE
Korean Journal of Dermatology 1995;33(4):705-709
We report a interesting case of acral lentigenous malignant melanoma associated with pseudocarcinomatous hyperplasia in a 65-year-old women A skin lesion showed a 5 x 5cm sized, black colored protruding mass with ulcerative surface on the right great toe for the last 10 years. Histopathological findings reveled hyperplasia of epidermis and the epithelium of the upper protion of the adnexa admixed with a proliferation of atypical epitheloid melanocytes that involved the mid and lower portion of the epidermis and the papillary dermis. There were dyskeratotic cells and pseudohorn cysts between the aggregates of atypical melanocytes. Immunhistochemical staining revealed that the nucleus and cytoplasm of the atypical epitheloid cells were strongly positive for S-100 protein and negative for keratin. Keratin staining revealed aggregates of positively stained kertinocytes with dyskeratosis and pseudohorn cysts admixed and trapped among negatively stained atypical melnocytes. A unusual case of malignant melanorna associated with pseudocarcinomatous hyperplasia in which conventional hematoxylin and eosin stained sections were difficult to differentiation between malignat melanoma and squamous cell carcinoma. Immunohistochemical staining for S-100 protein and keratin were essential in establesging the correct diagnosis.
Aged
;
Carcinoma, Squamous Cell
;
Cytoplasm
;
Dermis
;
Diagnosis
;
Eosine Yellowish-(YS)
;
Epidermis
;
Epithelium
;
Female
;
Hematoxylin
;
Humans
;
Hyperplasia*
;
Melanocytes
;
Melanoma*
;
S100 Proteins
;
Skin
;
Toes
;
Ulcer