Glucagoma is rare disease and has been reported only 100 cases so far worldwidely. The experience of this disease in our country is also lacking. The associated symptoms and signs can be characterized by necrolytic migratory erythematous lesion of the skin, hypoaminoacidemia, diabetes, weight loss, anemia, diarrhea, thrombocytopenia, glossitis. Among these, necrolytic migratory erythematous lesion of the skin is particulary considered as specific in this disease entity. In some cases, glucagonoma is diagnosed after metastasis to liver or bone marrow. Our patient initially diagnosed as having multiple metastatic adenocarcinoma of the liver. But subsequent development of the dermatologic manifestation enabled us to consider this rare disease. The constitutional symptoms and skin lesion abates rapidly at receiving Octreotide, somatostatin analogue, whereas no remarkable change observed after administration of the Zinc and aminoacid.
Adenocarcinoma ; Anemia ; Bone Marrow ; Diarrhea ; Erythema* ; Glossitis ; Glucagonoma* ; Humans ; Liver ; Neoplasm Metastasis* ; Octreotide ; Rare Diseases ; Skin ; Somatostatin ; Thrombocytopenia ; Weight Loss ; Zinc

Telomerase play a key role in the maintenance of telomere length and chromosome integrity. We have evaluated the association between telomerase activity and the risk of lung cancer in peripheral blood. Telomerase activity in peripheral blood mononuclear cells was measured by a PCR-designed telomeric repeat amplification protocol in 63 lung cancer patients and 190 healthy controls that were matched for age, gender, and smoking status. Telomerase activity was significantly lower in the lung cancer patients than in controls (mean +/- standard deviation; 1.32 +/- 1.65 vs 2.60 +/- 3.09, P < 1 x 10(-4)). When telomerase activity was categorized into quartiles based on telomerase activity in the controls, the risk of lung cancer increased as telomerase activity reduced (Ptrend = 1 x 10(-4)). Moreover, when the subjects were categorized based on the median value of telomerase activity, subjects with low telomerase activity were at a significantly increased risk of lung cancer compared to subjects with high telomerase activity (adjusted odds ratio = 3.05, 95% confidence interval = 1.60-5.82, P = 7 x 10-4). These findings suggest that telomerase activity may affect telomere maintenance, thereby contributing to susceptibility to lung cancer.
Age Factors ; Aged ; Case-Control Studies ; Female ; Humans ; Leukocytes, Mononuclear/enzymology/immunology ; Lung Neoplasms/*enzymology/*etiology ; Male ; Middle Aged ; Odds Ratio ; Risk Factors ; Sex Factors ; Smoking ; Telomerase/*blood