1.A case of reconstruction of tongue and oropharynx by RAMC flap.
Hoon Shik YANG ; Sung Joon PAIK ; Yong Wook PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(4):852-856
No abstract available.
Oropharynx*
;
Tongue*
2.Significance of PNS screening CT scan for functional endoscopicsinus surgery.
Seog In PAIK ; Ki Yeun KIM ; Hwang Min YOON ; Ki Joon SUNG
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(6):893-900
No abstract available.
Mass Screening*
;
Tomography, X-Ray Computed*
3.A method of the reconstruction of posterior canal wall and mastoid obliteration using cortical bone chips.
Hoon Shik YANG ; Myung Soo CHOE ; Sung Joon PAIK ; Chun Gil KIM ; Won Ju PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(5):904-912
No abstract available.
Mastoid*
4.Pre-Operative Perfusion Skewness and Kurtosis Are Potential Predictors of Progression-Free Survival after Partial Resection of Newly Diagnosed Glioblastoma.
Wooyul PAIK ; Ho Sung KIM ; Choong Gon CHOI ; Sang Joon KIM
Korean Journal of Radiology 2016;17(1):117-126
OBJECTIVE: To determine whether pre-operative perfusion skewness and kurtosis derived from normalized cerebral blood volume (nCBV) histograms are associated with progression-free survival (PFS) of patients after partial resection of newly diagnosed glioblastoma. MATERIALS AND METHODS: A total of 135 glioblastoma patients who had undergone partial resection of tumor (resection of < 50% of pre-operative tumor volume or surgical biopsy) confirmed with immediate postsurgical MRI and examined with both conventional MRI and dynamic susceptibility contrast (DSC) perfusion MRI before the surgery were retrospectively reviewed in this study. They had been followed up post-surgical chemoradiotherapy for tumor progression. Using histogram analyses of nCBV derived from pre-operative DSC perfusion MRI, patients were sub-classified into the following four groups: positive skewness and leptokurtosis (group 1); positive skewness and platykurtosis (group 2); negative skewness and leptokurtosis (group 3); negative skewness and platykurtosis (group 4). Kaplan-Meier analysis and multivariable Cox proportional hazards regression analysis were performed to determine whether clinical and imaging covariates were associated with PFS or overall survival (OS) of these patients. RESULTS: According to the Kaplan-Meier method, median PFS of group 1, 2, 3, and 4 was 62, 51, 39, and 41 weeks, respectively, with median OS of 82, 77, 77, and 72 weeks, respectively. In multivariable analyses with Cox proportional hazards regression, pre-operative skewness/kurtosis pattern (hazard ratio: 2.98 to 4.64; p < 0.001), Karnofsky performance scale score (hazard ratio: 1.04; p = 0.003), and post-operative tumor volume (hazard ratio: 1.04; p = 0.02) were independently associated with PFS but not with OS. CONCLUSION: Higher skewness and kurtosis of nCBV histogram before surgery were associated with longer PFS in patients with newly diagnosed glioblastoma after partial tumor resection.
Adult
;
Aged
;
Aged, 80 and over
;
Brain Neoplasms/*mortality/pathology/*surgery
;
Chemoradiotherapy
;
Disease-Free Survival
;
Female
;
Glioblastoma/*mortality/pathology/*surgery
;
Humans
;
Image Interpretation, Computer-Assisted
;
Image Processing, Computer-Assisted
;
Kaplan-Meier Estimate
;
Magnetic Resonance Imaging/methods
;
Male
;
Middle Aged
;
Regression Analysis
;
Retrospective Studies
;
Statistical Distributions
;
Tumor Burden
;
Young Adult
5.The Effect of Brimonidine on Transepithelial Resistance in a Human Retinal Pigment Epithelial Cell Line.
Jung Hyun PARK ; Sung Joon KIM ; Hyeong Gon YU
Korean Journal of Ophthalmology 2010;24(3):169-172
PURPOSE: To investigate the effects of brimonidine, an alpha-2-adrenergic agonist, on barrier function in ARPE-19 cells by measuring transepithelial resistance (TER). METHODS: ARPE-19 cells were cultured into a confluent monolayer on a microporous filter. Brimonidine was added to the apical medium, and the barrier function of the cells was evaluated by measuring TER. A subset of cells was treated under hypoxic conditions, and the TER changes observed upon administration of brimonidine were compared to those observed in cells in normoxic conditions. RESULTS: The ARPE cell membrane reached a peak resistance of 29.1+/-7.97 Omega cm2 after four weeks of culture. The TER of the cells treated under normoxic conditions increased with brimonidine treatment; however, the TER of the cells treated under hypoxic conditions did not change following the administration of brimonidine. CONCLUSIONS: Barrier function in ARPE-19 cells increased with brimonidine treatment. Understanding the exact mechanism of this barrier function change requires further investigation.
Adrenergic alpha-Agonists/*pharmacology
;
Cell Hypoxia/drug effects/physiology
;
Cell Line
;
Electric Impedance
;
Humans
;
Quinoxalines/*pharmacology
;
Receptors, Adrenergic, alpha-2/*drug effects
;
Retinal Pigment Epithelium/*drug effects/*physiology
6.Clinicopathologic Characteristics of Mucinous Gastric Adenocarcinoma.
Sung Joon KWON ; Jae Jung PARK ; Seung Sam PAIK
Journal of the Korean Surgical Society 2004;66(6):472-477
PURPOSE: Clinicopathological characteristics of mucinous gastric adenocarcinomas (MGC) are unclear. Also, whether the surgical results of a MGC are unfavorable is still controversial. A tumor is defined as a MGC when more than 30% of the tumor area has mucin pools. Also, MGC are subdivided into the well-differentiated (WD) and poorly differentiated (PD) types, according to the degree of glandular formation of the tumor cells. To clarify the significance of MGC, the clinicopathological profiles and prognoses of patients were studied. METHODS: Thirty-four patients with MGC and 1, 036 with non-mucinous gastric adenocarcinomas (NMGC) who were operated on between 1992 and 2002 at the Department of Surgery, Hanyang University Hospital, were included. Patients were evaluated with regard to age, gender, tumor location, size, depth of wall invasion, lymph node status, distant metastasis, stage at presentation, lymphatic and vascular permeation, operative curability, and preoperative serum levels of CEA and CA19-9. RESULTS: MGC tumors, compared with NMGC tumors, had larger sizes (8.0 vs. 5.9 cm), more frequent incidences of T2 or more invasion (91 vs. 66%), positive lymph node metastasis (85 vs. 57%), distant metastasis (18 vs. 6%), stage III and IV (74 vs. 45%), noncurative surgery (32 vs. 10%), lymphatic permeation (88 vs. 63%), and abnormal serum CEA level (32 vs. 14%). However, the overall survival rate of those patients with a MGC was not significantly different from that of those with a NMGC. With a MGC, there was no significant correlation between the degree of mucin content and the prognosis. Conversely, the survival rate was higher in the WD than in the PD types (100 vs. 45%, P=0.0185). CONCLUSION: The mucinous histological type itself is of no prognostic significance in patients with gastric carcinomas. The biological behavior of MGC is determined by the degree of glandular formation of the tumor cellss (i.e., histologic differentiation).
Adenocarcinoma*
;
Humans
;
Incidence
;
Lymph Nodes
;
Mucins*
;
Neoplasm Metastasis
;
Prognosis
;
Stomach Neoplasms
;
Survival Rate
7.Relationship between Alcohol Consumption and Obesity according to Facial Flushing in Korean Males
Won Yoon SUH ; Sung Soo KIM ; Jong Sung KIM ; Seok Joon YOON ; Sir Chae PAIK ; Jun Seok YANG
Korean Journal of Obesity 2015;24(4):206-211
BACKGROUND: This study was performed to examine the relationship between alcohol consumption and obesity according to facial flushing in Korean males. METHODS: The 1,198 men in this study were divided into four groups according to the amount of alcohol they consumed: non-drinkers (ND), lower moderate drinkers (LM, < or =7 standard drinks per week), higher moderate drinkers (HM, 7 to 14 drinks per week), and heavy drinkers (HD, >14 drinks per week). They were also separated into two groups according to facial flushing: non-flushers and flushers. Obesity and abdominal obesity were defined as body mass index of 25 kg/m2 or higher and waist circumference of 90 cm or higher, respectively. RESULTS: In LM and HM groups without flushing, the risks of obesity and abdominal obesity were not significantly increased compared to those of non-drinkers. However, in the HD group without flushing, those risks were significantly increased [OR, 1.55; confidence interval (CI), 1.01 to 2.40, and OR 1.63; CI 1.02 to 2.58, respectively]. In the LM group with flushing, those risks were not significantly increased. However, in HM and HD groups with flushing, the risks of obesity and abdominal obesity were significantly increased (OR, 2.10; CI, 1.07 to 4.16, and OR, 2.06; CI, 1.05 to 4.06, respectively, in HM; and OR, 2.16; CI, 1.08 to 4.34, and OR, 2.50; CI, 1.26 to 4.98, respectively, in HD). CONCLUSION: This study suggests that the risk of obesity is increased in moderate flushing drinkers compared to non-drinkers and in heavy non-flushing drinkers.
Alcohol Drinking
;
Body Mass Index
;
Flushing
;
Humans
;
Male
;
Obesity
;
Obesity, Abdominal
;
Waist Circumference
8.Clinical Scales Used in Motor Neuron Disease
Seong-il OH ; Jin-Sung PARK ; Jung-Joon SUNG ; Seung Hyun KIM
Journal of the Korean Neurological Association 2021;39(2 Suppl):77-86
Motor neuron diseases (MND) are heterogeneous spectra of disorders that that primarily affect the motor neurons (MN) resulting in motor nerve and muscle degeneration. The pathophysiological mechanisms of MN cell death are known to be combined with disturbance of proteostasis, ribonucleostasis and exaggerated neuro-inflammation. Amyotrophic lateral sclerosis is the prototypic disease of MND followed by spinal and bulbar muscular atrophy, spinal muscular atrophy, benign focal amyotrophy and other various diseases. Although diverse spectra of these diseases share common symptoms, significant differences are known in their clinical manifestations and their clinical progression. With increasing number of new clinical trials, the importance of selecting appropriate clinical scales for the monitoring of clinical progression in different types of MNDs should be emphasized. The purpose of this review is to illustrate different types of clinical scales and demonstrate how to utilize these in the clinical research field with consensus. With these efforts, we hope to be ready to understand different kinds of clinical scales in MND in participating global standard clinical trials.
9.Clinical Scales Used in Motor Neuron Disease
Seong-il OH ; Jin-Sung PARK ; Jung-Joon SUNG ; Seung Hyun KIM
Journal of the Korean Neurological Association 2021;39(2 Suppl):77-86
Motor neuron diseases (MND) are heterogeneous spectra of disorders that that primarily affect the motor neurons (MN) resulting in motor nerve and muscle degeneration. The pathophysiological mechanisms of MN cell death are known to be combined with disturbance of proteostasis, ribonucleostasis and exaggerated neuro-inflammation. Amyotrophic lateral sclerosis is the prototypic disease of MND followed by spinal and bulbar muscular atrophy, spinal muscular atrophy, benign focal amyotrophy and other various diseases. Although diverse spectra of these diseases share common symptoms, significant differences are known in their clinical manifestations and their clinical progression. With increasing number of new clinical trials, the importance of selecting appropriate clinical scales for the monitoring of clinical progression in different types of MNDs should be emphasized. The purpose of this review is to illustrate different types of clinical scales and demonstrate how to utilize these in the clinical research field with consensus. With these efforts, we hope to be ready to understand different kinds of clinical scales in MND in participating global standard clinical trials.
10.Case-Control Study for Contralateral Vesicoureteral Reflux in Patient with Unilateral Cohen's Reimplantation: Is Contralateral Vesicoureteral Reflux Caused by Postoperative Trigonal Distortion?.
Joon Ik PARK ; Ho Cheol CHOI ; Sung Hyup CHOI
Korean Journal of Urology 2001;42(10):1044-1048
PURPOSE: The development of contralateral reflux after successful unilateral antireflux surgery has led to controversy regarding etiology. Our aim was to analyze the incidence of newly developed contralateral reflux after successful unilateral Cohen's reimplantation in patients with grade III and IV reflux and to explain the postoperative trigonal distortion responsible for new contralateral reflux with case-control study. MATERIALS AND METHODS: We compared the incidence and outcome of contralateral reflux between the medical group with prophylactic antibiotics and the surgical group with unilateral Cohen's reimplantation in patients with unilateral vesicoureteral reflux. We retrospectively reviewed the records of 84 children seen in a 17-year period who had grade III (48 patients) and IV (36 patients) primary unilateral vesicoureteral reflux. Unilateral Cohen's reimplantation was done in 48 patients and prophylactic chemotherapy was done in 36 patients. RESULTS: Overall contralateral reflux developed in 13.8% of patients who underwent medical treatment and 14.6% of patients who underwent unilateral Cohen's reimplantation. In patients with grade III reflux, 13% of patients with medical treatment and 12% of patients with unilateral Cohen's reimplantation had contralateral reflux. Twelve patients with contralateral reflux had grade I (7 patients) and grade II (5 patients) reflux and resolved spontaneously within 18.2 months. CONCLUSIONS: The likelihood of trigonal distortion as the etiology of contralateral reflux is low given the similar incidence in cross-trigonal Cohen's reimplantation group and medical group with prophylactic chemotherapy in patients with grade III and IV primary vesicourerteral reflux.
Anti-Bacterial Agents
;
Case-Control Studies*
;
Child
;
Drug Therapy
;
Humans
;
Incidence
;
Replantation*
;
Retrospective Studies
;
Vesico-Ureteral Reflux*