Search Results

4.Effects of the Sanjoin on the Rat Brain: Focused on Serotonin, Sleeping Time, Sleep EEG and Autonomic Activity.

Hee Yeon JEONG ; Young Joon KWON ; In Joon PARK ; Joon Taek KWON ; Byung Hoon HAN ; Sung Pil LEE

Journal of the Korean Society of Biological Psychiatry 1997;4(1):54-59

OBJECTS: Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. METHOD: Sleeping time, sleep recordings of EEG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. RESULTS: 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded beta-wave in sleep recording of EEG. In there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. CONCLUSION: These results suggests that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.
Animals ; Asian Continental Ancestry Group ; Brain* ; Electroencephalography* ; Humans ; Hypnotics and Sedatives ; Lorazepam ; Motor Activity ; Rats* ; Serotonin* ; Sleep Initiation and Maintenance Disorders ; Ziziphus

5.Bypass Surgery in Unresectable Distal Gastric Cancer.

Sung Joon KWON

Journal of the Korean Surgical Society 1999;57(Suppl):984-989

BACKGROUND: The main purpose of bypass surgery in unresectable distal gastric cancer is to improve quality of life. However, the results of a conventional gastro-enterostomy are very dismal and include continuous bleeding due to contact of food material with the tumor surface and early obstruction of the stoma by tumor growth. METHODS: Eight hundred sixty two gastric-cancer patients were operated on between June 1992 and July 1999 at the Department of General Surgery, Hanyang University Medical Center, and 3.7% (32/862 cases) of them were unresectable. In this study, various kinds of gastro-jejunostomies (G-Jstomies), including conventional G-Jstomies (n=14), antral exclusion G-Jstomies (n=7), and gastric partitioning G-Jstomies (n=5) were retrospectively compared based on of survival and postoperative quality of life. Palliative gastrectomy cases (n=111) and explo-laparotomy only cases (n=6) were used as a control group for this study. RESULTS: The mean survival duration of the palliative gastrectomy group (20 2 months) was longer than those of the G-Jstomy (7 1 months) and the explo-laparotomy (4 1 months) groups (P=0.0000). However, there was no survival difference according to the type of G-Jstomy, and there was no statistically significant difference in hospital stay, diet start date, postoperative transfusion volume, or body weight change. Although the number of cases was too small and the clinicopathological profiles were not similar among the various G-Jstomy groups, the gastric partitioning G-Jstomy was very useful for endoscopically evaluating the tumor and for minimizing food contact with the tumor surface. CONCLUSIONS: The gastric partitioning G-Jstomy can be recommended as the choice of bypass surgery for unresectable distal gastric cancer due to its superiority in some aspects.
Academic Medical Centers ; Body Weight Changes ; Diet ; Gastrectomy ; Hemorrhage ; Humans ; Length of Stay ; Quality of Life ; Retrospective Studies ; Stomach Neoplasms*