No abstract available.
Factor VIII* ; Hemophilia A* ; Humans

BACKGROUND: the prediction on changes in the lung function after lung surgery would be an important indicator in terms of the operability and postoperative complications. In order to predict the postoperative FEV1 - the commonly used method for measuring changes in lung function- a comparison between the quantitative CT and the perfusion lung scan was made and proved its usefulness. MATERIAL AND METHOD: The subjects included 22 patients who received perfusion lung scan and quantitative CT preoperatively and with whom the follow-up of PFT were possibles out of the pool of patients who underwent right lobectomy or right pneumonectomy between June of 1997 and December of 1999. The FEV1 and FVC were calibrated by performing the PFT on each patient and then the predicted FEV1 and FVC were calculated after performing perfusion lung scan and quantitative CT postoperatively. The FEV1 and FVC were calibrated by performing the PFT after 1 week and after 3 momths following the surgery. RESULTS: There was a significant mutual scan and the actual postoperative FEV1 and FVC at 1 week and 3 months. The predicted FEV1 and FVC(pneumonectomy group : r=0.962 and r=0.938 lobectomy group ; r=0.921 and r=913) using quantitative CT at 1 week postoperatively showed a higher mutual relationship than that predicted by perfusion lung scan(pneumonectomy group : r=0.927 and r=0.890 lobectomy group : r=0.910 and r=0.905) The result was likewise at 3 months postoperatively(CT -pneumonectomy group : r=0.799 and r=0.882 lobectomy group : r=0.934 and r=0.932) CONCLUSION: In comparison to perfusion lung scan quantitative CT is more accurate in predicting lung function postoperatively and is cost-effective as well. Therefore it can be concluded that the quantitative CT is an effective method of replacing the perfusion lung scan in predicting lung function post-operatively. However it is noted that further comparative analysis using more data and follow-up studies of the patients is required.
Follow-Up Studies ; Humans ; Lung* ; Perfusion* ; Pneumonectomy ; Postoperative Complications

No abstract available.
Ambulatory Care Facilities* ; Humans ; Outpatients* ; Pharynx*

Two-dimensional Doppler echocardiographic velocity profiles of four cardiac valves in a group of 85 infants and children with left to right shunt lesions(VSD, ASD and PDA) are presented. Velocities were obtained before operation and 10 days afterward. The results were as follows ; 1) VSD(type 2) Peak velocities of mitral valve were significantly decreased when compared preop. with postop. echocardiogram(n=37, preop 132+/-24, postop 98+/-16 cm/sec, p<0.0005). Peak velocities of tricuspid valve were also significantly decreased(n=30, perop 60+/-21, postop 50+/-17cm/sec, p<0.01). Peak velocities of aortic valve were decreased(n=18, perop 120+/-20, postop 108+/-26cm/sec, 0.010.05). Peak velocities of pulmonic valve were significantly decreased(n=17, perop 168+/-46, postop 104+/-51cm/sec, p<0.0005). 3) PDA Peak velocities of mitral valve were significantly decreased when compared perop. with postop. echocardiogram(n=29, perop 138+/-28, postop 111+/-19cm/sec, p<0.0005). Tricuspid valve velocities showed no significant changes between preop. and postop. echocardiogram (n=15, perop 47+/-12, postop 44+/-10cm/sec, p>0.05). Aortic valve velocities showed no significant changes (n=10, perop 134+/-23, postop 121+/-25cm/sec, p>0.05). Peak velocities of pulmonic valve were significantly decreased(n=28, perop 138+/-37, postop 107+/-27cm/sec, p<0.005). This study demonstrates that Doppler echocardiographic assessment of velovity changes are correlated with known hemodynamic data and also will be a good index in the evaluation of operation.
Aortic Valve ; Child ; Echocardiography* ; Echocardiography, Doppler ; Heart Valves* ; Hemodynamics ; Humans ; Infant ; Mitral Valve ; Tricuspid Valve

No abstract available.
Hyperpigmentation*

We experinced a case of 4p+ syndrome in male infant. He had multiple anomalies such as flat occiput, hypertelorism, low set malformed ear, lower anterior hair line, depressed nose, broad nasal bridge, bilateral complete cleft lip and palate, short neck, unusual position of fingers, ventricular septal defect and umblical hernia. He menifested growth and developmental retardation. Karyotype with banding revealed an extra short arm of chromosome 4. The mother's karyotype was normal. His father and father's sister had a translocation between the short arm of chromosome 4 and the short arm of chromosome 9; their karyotypes were 46, XY, t(4;9) and 46, XX, t(4;9), respectively. In this case, trisomy 4p was the result of parental balanced translocatiom. As this is the first case in Korea, it is worthwhile to report with reviewing literature.
Arm ; Chromosomes, Human, Pair 4 ; Chromosomes, Human, Pair 9 ; Cleft Lip ; Ear ; Fathers ; Fingers ; Growth and Development ; Hair ; Heart Septal Defects, Ventricular ; Hernia ; Humans ; Hypertelorism ; Infant ; Karyotype ; Korea ; Male ; Neck ; Nose ; Palate ; Parents ; Siblings ; Trisomy

Mefloquine is a common anti-malarial agent used for the treatment and prophylaxis of malaria. Here we report a case of a 39-year-old, otherwise healthy woman from South Korea, who had developed visual and auditory hallucination with sleep disturbance after oral administration of mefloquine before traveling to an endemic region. To our knowledge, this would be the first reported case of mefloquine-induced psychosis in South Korea to date. This report underlines the importance of awareness and detection of neuropsychiatric side effects of mefloquine.
Administration, Oral ; Female ; Hallucinations ; Humans ; Malaria ; Mefloquine ; Psychotic Disorders ; Republic of Korea

It is well known that Bowen's.disease, a precancerous dermatosis can be associated with internal malignancy. We report 2 cases of Bowen's disease of probable arsenic origin associated with. internal malignancies. Case one, a 55 year-old man, who had the past history of arsenic intake and herb medication for the treatment of suspicious leprosy, had Bowen's disease and arsenical keratosis on his palms and soles with bronchogenic and stomach carcinoma. The other case, a 65 year-old man, who had history of intake of arsenic and herb medicine for epilepsy, had Bowen's disease and squamous cell carcinoma of the skin with stomach cancer. We suggest that in these 2 cases, the ingestion of organic arsenics might be the causative factor for the internal malignancy.
Aged ; Arsenic ; Bowen's Disease* ; Carcinoma, Squamous Cell ; Eating ; Epilepsy ; Humans ; Keratosis ; Leprosy ; Middle Aged ; Skin ; Skin Diseases ; Stomach ; Stomach Neoplasms

BACKGROUND: Even though there have been much improvment in general understanding of the climacteric period and increased knowledge of biological aspects of menopause such as Hormone Replacement Therapy, the psychosocial aspects of climacterium was relatively out of consideration. The purpose of this paper is to help make it easy understanding the psychosocial determinants of climacterium through the investigation of correlation between the life stress and the climacteric symptoms in the middle aged women. METHODS: This study was performed on climacteric women at the age ranging from 40 to 55 who reside in Kyong-Ju city. Self reported questionnaires composed of inquiry about demographic characteristics, climacteric symptom scale, and life stress scale were distributed and 123 cases were analyzed in June. and July 1996. The Climacteric Symptom Scale was developed by JG Greene in 1976. In this scale, climacteric symptoms were classified to 3 categories of psychological, somatic, vasomotor symptoms by factor analysis. For quantitative measurement of stress, we used Office Stress Measurement Scale developed by Bae JM et al in 1992. We studied the correlation between stress scores and each class of climacteric symptoms, and the difference of climacteric symptom scores according to the menopausal status and demographic characteristics. RESULTS: The correlation coefficient between the climacteric symptom scores and the stress scores was 0.329(P=0.000) but this correlation was significant in only premenopausal group(correlation coefficient=0.479). Among climacteric symptom classes, the correlation with stress scores is most prominent in psychological symptom class, then somatic symptoms, vasomotor symptoms. There was no difference in climacteric symptom scores to the menopausal status and demographic characteristics. CONCLUSIONS: Women who had more stress complained more climacteric symptoms, especially psychological symptoms. This correlation was significant in the premenopausal group only. And the severity of climacteric symptoms didnt change by demographic characteristics.
Climacteric* ; Female ; Gyeongsangbuk-do ; Hormone Replacement Therapy ; Humans ; Menopause ; Middle Aged ; Self Report ; Stress, Psychological* ; Surveys and Questionnaires

BACKGROUND: Even though there have been much improvment in general understanding of the climacteric period and increased knowledge of biological aspects of menopause such as Hormone Replacement Therapy, the psychosocial aspects of climacterium was relatively out of consideration. The purpose of this paper is to help make it easy understanding the psychosocial determinants of climacterium through the investigation of correlation between the life stress and the climacteric symptoms in the middle aged women. METHODS: This study was performed on climacteric women at the age ranging from 40 to 55 who reside in Kyong-Ju city. Self reported questionnaires composed of inquiry about demographic characteristics, climacteric symptom scale, and life stress scale were distributed and 123 cases were analyzed in June. and July 1996. The Climacteric Symptom Scale was developed by JG Greene in 1976. In this scale, climacteric symptoms were classified to 3 categories of psychological, somatic, vasomotor symptoms by factor analysis. For quantitative measurement of stress, we used Office Stress Measurement Scale developed by Bae JM et al in 1992. We studied the correlation between stress scores and each class of climacteric symptoms, and the difference of climacteric symptom scores according to the menopausal status and demographic characteristics. RESULTS: The correlation coefficient between the climacteric symptom scores and the stress scores was 0.329(P=0.000) but this correlation was significant in only premenopausal group(correlation coefficient=0.479). Among climacteric symptom classes, the correlation with stress scores is most prominent in psychological symptom class, then somatic symptoms, vasomotor symptoms. There was no difference in climacteric symptom scores to the menopausal status and demographic characteristics. CONCLUSIONS: Women who had more stress complained more climacteric symptoms, especially psychological symptoms. This correlation was significant in the premenopausal group only. And the severity of climacteric symptoms didnt change by demographic characteristics.
Climacteric* ; Female ; Gyeongsangbuk-do ; Hormone Replacement Therapy ; Humans ; Menopause ; Middle Aged ; Self Report ; Stress, Psychological* ; Surveys and Questionnaires